Collagen xenografts for bone replacement: The effects of aldehyde-induced cross-linking on degradation rate

DeVore, Duane T.

doi:10.1016/0030-4220(77)90050-0

Cited by 25 publications

(2 citation statements)

References 16 publications

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“…30 The osteoconductive type I collagen gels used in this study may have provided a better cellular environment than pepsinated bovine collagen or aldehyde cross-linked bovine skin collagen, which are currently commercially available and have shown little potential to promote bone repair in several other studies. 1,[7][8][9]17,26,28 Collagen may act primarily as an osteoconductive matrix and secondarily as a binding agent for osteoinductive growth factors. 3,20,23 In this study, type I collagen gel seemed to improve the interface between the fusion mass and adjacent lamina and spinous processes, suggesting that the gels may fill the spaces between autologous bone chips and host bone and provide a continuous osteoconductive matrix for the growth of osteogenic cells.…”

Section: Discussionmentioning

confidence: 99%

Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion

Helm

Sheehan²,

Sheehan³

et al. 1997

Journal of Neurosurgery

106

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Autologous bone grafts are currently considered "gold standard" material for achieving long-term spinal arthrodesis. The present study was performed to determine whether demineralized bone matrix (DBM), type I collagen gels, or bone morphogenetic protein-2 (BMP-2) can improve autologous bone spinal fusions. Using a unilateral decompression-contralateral fusion technique in dogs, each of these materials was added to an autologous bone graft. Volumetric analysis, histological analysis, and biomechanical testing were performed to assess the effectiveness of each material. The DBM had an inhibitory effect on solid bone fusion of the spine, whereas the type I collagen gels improved the bony interface between the graft and the host spine. The BMP-2 strongly enhanced the amount of bone deposition at the fusion site and increased the number of intervertebral levels that were solidly fused. This study strongly supports the use of BMP-2 as an additive to autologous bone grafts in spine stabilization.

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Section: Discussionmentioning

confidence: 99%

Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion

Helm

Sheehan²,

Sheehan³

et al. 1997

Journal of Neurosurgery

106

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“…Devore et al (12) used collagen cross-linked with glutaraldehyde as a bone replacement material in bone defects, and observed differences in the period of in vivo absorption that were dependent on the intensity of the cross-hnking. The HMDIC used for cross-linking in the present study is less cytotoxic in vitro than glutaraldehyde, and permits more delicate control of the cross-linking intensity in comparison with physical means such as gamma rays and UV (13).…”

Section: Discussionmentioning

confidence: 99%

Effects of atelocollagen on the wound healing reaction following palatal gingivectomy in rats

Minabe

Kodama

Hori

et al. 1989

J of Periodontal Research

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Collagen membrane preparations have been manufactured with the aim of enhancing wound healing following periodontal surgery. After cross-linking by various processing methods (with ultraviolet radiation or hexamethylenediisocyanate) and to various extents, atelocollagen membranes were applied into dissection sites within palatal gingival tissue. Applied atelocollagen was histopathologically compared with applied lyophilized porcine dermis (LPD) and controls in rats, with regard to the time course of healing. The atelocollagen-applied group showed more satisfactory regeneration of the epithelium and connective tissue in an artificially created gingival defect than did the control group or the LPD-applied group. Epithelial downgrowth along the root surface was significantly suppressed by the use of atelocollagen. In addition, the post-operative inflammatory reaction and foreign body giant cell reaction subsided rapidly after surgery in the atelocollgen-applied group. Our results show that the use of atelocollagen membrane in periodontal wounds should be the method of choice.

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Biopolymer ‐Based Nanocomposites for Environmental Applications

El‐Sherbiny

Ali

2017

Handbook of Composites From Renewable Materials

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Collagen xenografts for bone replacement: The effects of aldehyde-induced cross-linking on degradation rate

Cited by 25 publications

References 16 publications

Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion

Utilization of type I collagen gel, demineralized bone matrix, and bone morphogenetic protein-2 to enhance autologous bone lumbar spinal fusion

Effects of atelocollagen on the wound healing reaction following palatal gingivectomy in rats

Biopolymer ‐Based Nanocomposites for Environmental Applications

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