Collagen Vascular Disorders

Neonatal lupus erythematosus-three different presentations

“…However, both these manifestation coexist only in 10% patients. [2] Other manifestations includes liver involvement (10-26%), [1,4] hematologic involvement (27%). [1,4] Like SLE, the cutaneous manifestation in NLE is also varied.…”

“…[2] Other manifestations includes liver involvement (10-26%), [1,4] hematologic involvement (27%). [1,4] Like SLE, the cutaneous manifestation in NLE is also varied. Child can present with erythematous annular lesions, polycyclic lesions, atrophic discoid lesions, and purpuric lesions.…”

“…Small percentage of NLE is associated with anti-U 1 ribonuclear protein antibodies. [1] Almost all the mothers who have a child with NLE are anti-Ro/SSA positive [2,3] and around 50% mothers are anti-LA/SSB positive. [2] Around 2% of general population is positive for anti-SSA antibody.…”

“…Cutaneous manifestations of NLE includes annular lesions, periorbital erythema (raccoon eyes), discoid lesion, and atrophic patches. [1] Because of rarity of the condition and self-limiting nature of the illness, the diagnosis can be missed. Three cases of neonatal lupus with skin involvement are presented.…”

“…NLE is usually associated with anti-Ro (SSA), anti-La (SSB) autoantibodies. [1] Like systemic lupus erythematosus (SLE), NLE presents with multi-organ involvement but skin and heart are the main targets. Cutaneous manifestations of NLE includes annular lesions, periorbital erythema (raccoon eyes), discoid lesion, and atrophic patches.…”