Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Wu, Zhuning; Korntner, SH; Mullen, AM; Zeugolis, Dimitrios I.

doi:10.1016/j.bbiosy.2021.100030

Cited by 21 publications

(18 citation statements)

References 224 publications

(224 reference statements)

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“…Articular cartilage is a layer of connective tissue encased in the surface of the joint, which has the function of bearing mechanical load, lubricating the joint, maximizing absorption, buffering stress, etc. 1,2 In cases of acute trauma and chronic wear, articular cartilage will suffer from varying degrees of damage, oen causing joint pain, limited mobility, and even loss of function. [3][4][5] Due to the low degree of vascularization, the nutrition of cartilage tissue mainly comes from the joint uid, and its ability to regenerate is very limited if a traumatic or pathological event occurs.…”

Section: Introductionmentioning

confidence: 99%

“…For example, collagen bers are parallel to the articular surface in the supercial regions of the articular cartilage and even perpendicular to the articular surface in the deep regions. 2,3,17 Therefore, the ideal biological material should have the ability to rebuild three-dimensional tissue and have the structure of mimicking natural cartilage tissue.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

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“…Collagens are the most common family, with more than 20 distinct collagen types recognized currently [ 97 , 98 , 99 , 100 ]. Collagens are essential for the production of extracellular matrix fibrillar and microfibrillar networks, basement membranes, and other extracellular matrix structures [ 101 , 102 ].…”

Section: Recent Advancements In Biopolymers-derived Materials For Sup...mentioning

confidence: 99%

Biopolymers-Derived Materials for Supercapacitors: Recent Trends, Challenges, and Future Prospects

et al. 2022

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Supercapacitors may be able to store more energy while maintaining fast charging times; however, they need low-cost and sophisticated electrode materials. Developing innovative and effective carbon-based electrode materials from naturally occurring chemical components is thus critical for supercapacitor development. In this context, biopolymer-derived porous carbon electrode materials for energy storage applications have gained considerable momentum due to their wide accessibility, high porosity, cost-effectiveness, low weight, biodegradability, and environmental friendliness. Moreover, the carbon structures derived from biopolymeric materials possess unique compositional, morphological, and electrochemical properties. This review aims to emphasize (i) the comprehensive concepts of biopolymers and supercapacitors to approach smart carbon-based materials for supercapacitors, (ii) synthesis strategies for biopolymer derived nanostructured carbons, (iii) recent advancements in biopolymer derived nanostructured carbons for supercapacitors, and (iv) challenges and future prospects from the viewpoint of green chemistry-based energy storage. This study is likely to be useful to the scientific community interested in the design of low-cost, efficient, and green electrode materials for supercapacitors as well as various types of electrocatalysis for energy production.

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“…Moreover, it has also been hypothesized that the developed hydrogel could be an alternative to TMJ disc replacement materials including temporal myofascial flaps and acellular matrix tissue patches for the treatment of TMJ disorders without any surgical risk or postoperative absorption. Up to date, even though various injectable and self-healable hydrogels have been developed for traumatic spinal cord injury, 19 chondral defect repair, 20 and other cartilage engineering applications, 21 to the best of our knowledge, the rheological properties of these hydrogels were not investigated based on the suitability of injection to TMJ. The chemical structure of synthesized hydrogels was characterized by Fourier transform infrared (FTIR), while their porosity properties were investigated by micro-computed tomography (μ-CT).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of an injectable heparin conjugated poloxamer hydrogel with high elastic recoverability for temporomandibular joint disorders

Deliogullari

Ilhan‐Ayisigi

Cakmak

et al. 2022

J of Applied Polymer Sci

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The temporomandibular joint (TMJ) is commonly affected during fundamental oral activities, reducing the quality of life. Herein, we synthesized a heparinconjugated poloxamer hydrogel (HEP) as a thermo-responsive injectable hydrogel for the treatment of TMJ disorders. While the gelation temperature of synthesized HEP (25% [w/v]) was 29.8-30.0 C, there was a slight difference between loss and storage modulus. HEP decreased the friction of the TMJ, thus requires less energy during load-bearing jaw movement in comparison to POL. Moreover, the oscillation test dependent on strain ranges from 0.01% to 1000% validated that POL and HEP3 hydrogels showed a similar critical strain of about 5.6%. The total elastic recovery percentage of HEP3 (53.50%) was higher than POL (45.55%), indicating a better recovery of the deformed hydrogel structure. Along with the suitable viscoelastic properties for temporomandibular cavity, both hydrogels increased the proliferation of fibroblasts (L929) and chondrocytes (ATDC5) (cell viabilities were above 100%). However, newly synthesized HEP induced differentiated cell proliferation of chondrogenic cells at increasing concentrations up to 0.0156 mg/mL (p < 0.0001) compared to POL and the control group. The promising rheological properties and effects on chondrogenic cell proliferation of injectable heparin-conjugated hydrogel make them candidates for intra-articular injections used for the treatment of TMJ.

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Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering

Cited by 21 publications

References 224 publications

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Biopolymers-Derived Materials for Supercapacitors: Recent Trends, Challenges, and Future Prospects

Synthesis of an injectable heparin conjugated poloxamer hydrogel with high elastic recoverability for temporomandibular joint disorders

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