Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates

Bagán, José; Jiménez, Yolanda; Gómez, Dolores; Sirera, Rafael; Poveda, Rafael; Scully, Crispian

doi:10.1016/j.oraloncology.2008.01.012

Cited by 78 publications

(47 citation statements)

References 6 publications

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“…In patients already receiving bisphosphonates, where possible, discontinuing bisphosphonate treatment when a dental surgical procedure is necessary is also being investigated, as well as maintaining good oral hygiene. The CTX-level (c terminal telopeptide of collagen) as a marker for the risk of developing a BP-ONJ has been discussed previously (19,20). The treatment of BP-ONJ ranges from mouth rinses to resection of the affected area.…”

Section: Discussionmentioning

confidence: 99%

Effects of a low-level diode laser on oral keratinocytes, oral fibroblasts, endothelial cells and osteoblasts incubated with bisphosphonates: An in vitro study

Pabst

Ziebart

2014

Biomedical Reports

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Abstract. Bisphosphonate-associated osteonecrosis of the jaw may have multiple causes, including altered bone remodeling, angiogenesis inhibition and impact of bisphosphonate on the soft tissues. Successful treatment is difficult. As a positive effect of low-level laser application on wound healing is well known, an in vitro study was designed to analyze the effect of low-level laser (280 mW, 670 nm) treatment on keratinocytes, fibroblasts, endothelial cells and osteoblasts treated with clodronate, ibandronate, pamidronate or zoledronate. Pure irradiation had a positive effect on cell viability, whereas bisphosphonate treatment had a negative impact. Viability was significantly increased in cells treated with bisphosphonates and sequel irradiation. There was no effect when the bisphosphonate medium was irradiated. The revealed effect of laser stimulation on cell viability is not due to an inactivation of the bisphosphonates. These results may support the idea of low-level laser therapy as a supportive therapy in patients receiving bisphosphonates to prevent and treat bisphosphonate-associated osteonecrosis of the jaw.

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Section: Discussionmentioning

confidence: 99%

Effects of a low-level diode laser on oral keratinocytes, oral fibroblasts, endothelial cells and osteoblasts incubated with bisphosphonates: An in vitro study

Pabst

Ziebart

2014

Biomedical Reports

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“…When values lower than 150 pg/mL are obtained, then medication should cease for a period of between four and six months or an alternative treatment option involving other types of prosthesis should be sought. Nevertheless, Bágan et al (20) did not find a significant relation between this test and the number of exposed osseous areas or the size of necrotic areas in cancer patients treated intravenously with bisphosphonates.…”

Section: Discussionmentioning

confidence: 88%

Dental implants in patients treated with oral Bisphosphonates: A bibliographic review

Montoya-Carralero¹,

Parra-Mino²,

Fernández³

et al. 2009

Med Oral

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Bisphosphonates inhibit bone resorption and are used to treat a range of pathologies, including Paget disease, osteoporosis, multiple myeloma and metastases associated with breast or prostate cancer. At present, there is no effective treatment for bisphosphonate induced osteonecrosis, so prevention is extremely important. Since quality of life deteriorates for those suffering osteonecrosis, maximum precautions should be taken with patients at risk, and especially whenever oral surgery, including dental implant placement, is contemplated. Dentists and oral or maxillofacial surgeons must keep up to date with the latest approaches to prevention, particularly when treating patients who are presently taking, or who will be taking bisphosphonates and are also candidates for dental implants.

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“…Therefore, it can be questioned whether an arbitrarily defined cutoff of 150 pg/ml that does not take into account pre-therapy baseline CTX-I levels is universally appropriate. In fact, recently published reports cast doubt on the reliability of CTX-I by failing to demonstrate a significant relationship between the marker and the severity of ONJ and the fact that some patients with ONJ have bone markers that are within the normal range [59,60].…”

Section: Risk Stratification Using Bone Turnover Markersmentioning

confidence: 99%

Gem-Diphosphonates: The Motif of Diverse Biological and Medicinal Importance

Abdou¹,

Barghash²

2015

JPP

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Collagen telopeptide (serum CTX) and its relationship with the size and number of lesions in osteonecrosis of the jaws in cancer patients on intravenous bisphosphonates

Cited by 78 publications

References 6 publications

Effects of a low-level diode laser on oral keratinocytes, oral fibroblasts, endothelial cells and osteoblasts incubated with bisphosphonates: An in vitro study

Effects of a low-level diode laser on oral keratinocytes, oral fibroblasts, endothelial cells and osteoblasts incubated with bisphosphonates: An in vitro study

Dental implants in patients treated with oral Bisphosphonates: A bibliographic review

Gem-Diphosphonates: The Motif of Diverse Biological and Medicinal Importance

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