Collagen Synthesis Modulated in Wounds Treated by Pulsed Radiofrequency Energy

Kao, Huang‐Kai; Li, Qin; Flynn, Brendan P.; Qiao, Xiaoyin; Ruberti, Jeffrey W.; Murphy, Gëorge F.; Guo, Lifei

doi:10.1097/prs.0b013e3182827636

Cited by 12 publications

(10 citation statements)

References 32 publications

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“…Radiofrequency (RF)‐induced heating has been shown to induce tissue tightening and contraction through effects on the collagen fiber network of the tissue. These effects are both acute, through the immediate contraction of existing collagen proteins, and longer term, through the induction of the production of new collagen 10,11 . The safety and efficacy of a minimally invasive temperature‐controlled RF device designed to cause these tissue tightening effects within the submucosal layer of the lateral nasal wall, the Vivaer Stylus (Aerin Medical, Sunnyvale, CA), for the treatment of nasal valve collapse and NAO has been established in single‐arm studies and demonstrated that early 3‐month improvements were durable through 2‐year follow‐up 12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…These effects are both acute, through the immediate contraction of existing collagen proteins, and longer term, through the induction of the production of new collagen. 10 , 11 The safety and efficacy of a minimally invasive temperature‐controlled RF device designed to cause these tissue tightening effects within the submucosal layer of the lateral nasal wall, the Vivaer Stylus (Aerin Medical, Sunnyvale, CA), for the treatment of nasal valve collapse and NAO has been established in single‐arm studies and demonstrated that early 3‐month improvements were durable through 2‐year follow‐up. 12 , 13 The objective of this study was to provide higher level evidence to determine the safety and efficacy of the Vivaer Stylus in a randomized controlled trial (RCT) with a sham procedure as the control arm.…”

Section: Introductionmentioning

confidence: 99%

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Temperature‐controlled radiofrequency device treatment of the nasal valve for nasal airway obstruction: A randomized controlled trial

Silvers¹,

Rosenthal

McDuffie³

et al. 2021

Int Forum Allergy Rhinol

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Background: Nasal valve collapse is one of several causes of nasal obstruction.The safety and efficacy of a temperature-controlled radiofrequency (RF) device for the treatment of the nasal valve for nasal airway obstruction (NAO) has been established in single-arm studies. The objective of this trial was to compare active device treatment against a sham procedure (control). Methods: In a prospective, multicenter, single-blinded, randomized controlled trial (RCT), patients were assigned to bilateral temperature-controlled RF treatment of the nasal valve (n = 77) or a sham procedure (n = 41), in which no RF energy was transferred to the device/treatment area. The device was applied to the mucosa over the lower lateral cartilage on the lateral nasal wall. The primary endpoint was responder rate at 3 months, defined as a ≥20% reduction in Nasal Obstruction Symptom Evaluation (NOSE)-scale score or ≥1 reduction in clinical severity category.Results: At baseline, patients had a mean NOSE-scale score of 76.7 (95% confidence interval [CI], 73.8 to 79.5) and 78.8 (95% CI, 74.2 to 83.3) (p = 0.424) in the active treatment and sham-control arms, respectively. At 3 months, the responder rate was significantly higher in the active treatment arm (88.3% [95% CI, 79.2%-93.7%] vs 42.5% [95% CI, 28.5%-57.8%]; p < 0.001). The active treatment arm had a significantly greater decrease in NOSE-scale score (mean, −42.3 [95% CI, −47.6 to −37.1] vs −16.8 [95% CI, −26.3 to −7.2]; p < 0.001). Three adverse events at least possibly related to the device and/or procedure were reported, and all resolved. Conclusion:This RCT shows temperature-controlled RF treatment of the nasal valve is safe and effective in reducing symptoms of NAO in short-term follow-up.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Temperature‐controlled radiofrequency device treatment of the nasal valve for nasal airway obstruction: A randomized controlled trial

Silvers¹,

Rosenthal

McDuffie³

et al. 2021

Int Forum Allergy Rhinol

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“…Likewise, in surgically injured diabetic mice, RF exposure induced accelerated closure of the skin incision by promoting proliferation of dermal cells (Li et al 2011), acceleration of neocollagenogenesis and neoangiogenesis and increase of dermal thickness (Meyer et al 2017). At the cellular level, in vitro exposure to pulsed RF currents has been reported to increase cell proliferation and collagenogenesis in fibroblasts (Kao et al 2013).…”

Section: Introductionmentioning

confidence: 99%

In vitro stimulation with radiofrequency currents promotes proliferation and migration in human keratinocytes and fibroblasts

Hernández-Bule

Toledano-Macías

Naranjo

et al. 2021

Electromagnetic Biology and Medicine

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Capacitive-resistive electric transfer (CRET) therapies have been proposed as strategies for regeneration of cutaneous tissue lesions. Previous studies by our group have shown that intermittent stimulation with 448 kHz CRET currents at subthermal densities promotes in vitro proliferation of human stem cells involved in tissue regeneration. The present study investigates the effects of the in vitro exposure to these radiofrequency (RF) currents on the proliferation and migration of keratinocytes and fibroblasts, the main cell types involved in skin regeneration. The effects of the electric stimulation on cell proliferation and migration were studied through XTT and wound closure assays, respectively. The CRET effects on the expression and location of proteins involved in proliferation and migration were assessed by immunoblot and immunofluorescence. The obtained results reveal that electrostimulation promotes proliferation and/or migration in keratinocytes and fibroblasts. These effects would be mediated by changes observed in the expression and location of intercellular adhesion proteins such as β-catenin and E-cadherin, of proteins involved in cell-to-substrate adhesion such as vinculin, p-FAK and the metalloproteinase MMP-9, and of other proteins that control both processes: MAP kinases p-p38, p-JUNK and p-ERK1/2. These responses could represent a mechanism underlying the promotion of normotrophic wound regeneration induced by CRET. Indeed, electric stimulation would favor completion of granulation tissue formation prior to the closure of the outer tissue layers, thus preventing abnormal wound cicatrization or chronification.

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“…The use of coblation thereby reduces the likelihood of collateral tissue damage, whilst also minimising or even eliminating the risk of airway fires 31 . Coblation has been shown to enhance the healing of long-standing cutaneous ulcers; 32 this is thought to be due to an inhibition of fibroblast growth, and represents an additional benefit of the plasma field 33 . In addition, in an unprotected airway, a rapid, haemostatic and precise resection of stenotic tissue reduces the risks of CO 2 retention and barotrauma, and minimises anaesthetic morbidity and trauma associated with airway instrumentation.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of airway stenosis by radiofrequency coblation

et al. 2014

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Collagen Synthesis Modulated in Wounds Treated by Pulsed Radiofrequency Energy

Abstract: Exposing wounds to pulsed radiofrequency accelerated wound healing in this diabetic mouse model by means of significantly increasing dermal cell proliferation and collagen synthesis. A cellular mechanism behind these observations has been proposed.

Cited by 12 publications

References 32 publications

Temperature‐controlled radiofrequency device treatment of the nasal valve for nasal airway obstruction: A randomized controlled trial

Temperature‐controlled radiofrequency device treatment of the nasal valve for nasal airway obstruction: A randomized controlled trial

In vitro stimulation with radiofrequency currents promotes proliferation and migration in human keratinocytes and fibroblasts

Surgical management of airway stenosis by radiofrequency coblation

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