Collagen resorption by hepatocytes during regression of cirrhosis of the liver

Ultrastructural characteristic of collagen resorption in cirrhotic liver

“…These morphological signs of collagen resorption [3] were confirmed by experiments showing that hepatocytes and KC are involved in collagen resorption [ 1,[8][9][10][11][12][13][14][15]. Hepatic lysosomal fraction contains collagenase-like enzymes [30].…”

“…Our findings and results of other authors indicate that hepatocytes and KC synthesize [4,28,37] and lyse [ 1,3,7,[8][9][10][11][12][13][14][15]] fibrillar proteins, which reflects antagonistic regulation of functions, the general biological feature and a part of the multistage (nervous, hormonal, and humoral) regulation of homeostasis [5,17,20]. Antagonistic cells were found in various organs [17,20].…”