Collagen/Polypropylene Composite Mesh Biocompatibility in Abdominal Wall Reconstruction

Abstract

Visceral adhesions to polypropylene mesh are significantly reduced because of acetic acid extracted collagen coating. The collagen coating does not increase complications or induce alterations of polypropylene mesh incorporation.

Treatment of abdominal wall hernia with suture, or polypropylene, or collagen prosthesis

“…By contrast, it could be observed that the type I collagen mesh behaved similarly to the host tissue by not unleashing an inflammatory reaction upon the foreign body 3,7,17 . In addition, it was impossible, by optical microscopy and by the methods used in this study, to differentiate between the collagen of the biological implant and that of the host.…”

“…Advances in tissue engineering technology have led to the development of biomaterials derived from human and animal tissues 7,12,13 . These materials differ amongst themselves, as they act through a regenerative process.…”

“…The setting of the mesh allows for the stress-free restoration of the structural integrity of the abdominal wall. Advantages for the use of mesh include its availability, non-dependence on integrity, as well as the resistance of the patient's tissues 3,7 . The ideal material for the implant must be atoxic, non-immunogenic, and non-reactive 8,9 , aimed at using the implant and incorporating it within the surrounding tissues.…”

Polypropylene meshes and other alloplastic implants for soft tissue and cartilage nasal reconstructive surgery – a literature review

“…There are studies that explain that using a collagen/polypropylene mesh intraperitoneally can decrease visceral adhesion. An acetic acid extracted collagen coating experiment was developed in experimental rats and the results were very good, with few complications and a good biocompatibility of the polypropylene mesh 40 . Collagen/ polypropylene composite meshes (Parieten ® ) can increase the infection rate in experimental rats, but it has very good biocompatibility and low adhesion rate in laparoscopic incisional hernia repair 41 .…”

Protocol for a Randomized Phase II Trial for Mesh Optimization by Autologous Plasma Coating in Prolapse Repair: IDEAL Stage 3

“…Finally, in 2016 the FDA changed the risk class from II to high risk III for vaginal mesh for POP treatment [7]. For meshes currently used in surgeries for hernia, incontinence (SUI), and prolapse (POP) conditions, respectively, the optimization of biocompatibility features has gained increasing focus in clinical and preclinical research and sophisticated methods have been developed [8,9]. However, none of those approaches have progressed beyond experimental stages and were therefore not further investigated or applied in humans.…”