Collagen Phagocytosis by Fibroblasts in the Periodontal Ligament of the Mouse Molar During the Initial Phase of Hypofunction

Beertsen, W.

doi:10.1177/00220345870660120201

Cited by 22 publications

(11 citation statements)

References 16 publications

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“…In the absence of function, the PDL undergoes atrophic changes, such as a reduction in the number and disorganization of collagen fibers, an increase in collagen remodeling , a decrease in the diameter and number of blood vessels, a decrease in periostin expression , and a decrease in the number of fibroblast cells . In those studies the absence of function was obtained by extracting opposing teeth on one side, thus creating functionless and supra‐erupted teeth.…”

Section: Discussionmentioning

confidence: 99%

Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla

Denes

Mavropoulos

Bresin

et al. 2013

European J Oral Sciences

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Previous studies have established that complete absence of masticatory function results in a narrower alveolar process and periodontal ligament (PDL). The aim of our study was to investigate, for the first time, both the alveolar process and the PDL in masticatory hypofunction. Twenty-six rats, 3 wk of age, were randomly assigned to either a hard- or a soft-diet group (n = 13 each group). The rats were killed after 6 wk and their skulls were scanned using micro-computed tomography (micro-CT). We measured the cross-sectional width of the space occupied by the PDL, as well as the cross-sectional alveolar socket surface (AS) and the cross-sectional root surface (RS). We also measured the width of the alveolar process. The alveolar process was narrower, the PDL width was thinner, and the AS was smaller in rats fed a soft diet compared with rats fed a hard diet. The PDL width was correlated to the alveolar process width and the AS. The narrower alveolar process found in rats fed a soft diet is the result of alterations to both the alveolar bone and the PDL. The correlation between them provides evidence that a reduction of occlusal loading induces a simultaneous response in both tissues.

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Section: Discussionmentioning

confidence: 99%

Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla

Denes

Mavropoulos

Bresin

et al. 2013

European J Oral Sciences

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“…These observations confirm our supposition (see Materials and Methods) that unopposed teeth are more suitable than opposed ones for the development of ankylosis in a model system. Hypofunction results after some time in disuse atrophy of the periodontium (Cohn 1965, Beertsen 1987. After 50 days of HEBP admininstration, some resorptions were seen along the acellular cementum in areas where the periodontal ligament space was re-duced to a very narrow connective tissue layer.…”

Section: Discussionmentioning

confidence: 99%

Ankylosis of the mouse molar after systemic administration of 1‐hydroxyethylidene‐1,1‐bisphosphonate (HEBP)

Wesselink

Beertsen

1994

J Clinic Periodontology

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The proposed homeostasis between fibroblasts in the periodontal ligament and bone cells lining the inner aspect of the alveolar wall is thought to be responsible for maintaining the width of the periodontal ligament space. In the present study, we attempted to interfere with this cellular balance by systemic administration of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP). The maxillary left molars of mice were extracted. They then received a daily subcutaneous injection of HEBP (10 mg P/kg b.w.) for periods of 10, 30 or 50 days. A 2nd group of animals received HEBP without molar extraction. Control groups were injected with Ringer's solution. The animals were sacrificed after the last injection and the mandibles processed for light and electron microscopy. HEBP treatment caused a significant decrease of the width of the periodontal ligament space which was influenced by time. Ankylosis started to occur after 30 days, predominantly in the interradicular areas and was more common around unopposed teeth. At 50 days, signs of resorption were seen along the acellular cementum layer. During HEBP-administration, extensive deposition of newly formed cementum matrix was observed along the cellular cementum but this activity was not seen along the acellular cementum. It is concluded that HEBP interferes with the mechanisms that mediate preservation of the periodontal ligament width.

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“…The increased new bone mass likely resulted from supraeruption of the second molar tooth which displaced the mucoperiosteum and in- creased the strain delivered to crestal alveolar bone by alveolar crest (Rippin, 1976) or alveologingival fibers (Johnson, 1989). Increased collagenous protein synthesis (Johnson, 1989) and decreased collagen degradation rates (Beertsen, 1987) are reported in hypofunctional periodontal tissues, suggesting that this ligament should become wider (Cohn, 1965). The reduction in transseptal ligament thickness, reported herein, could result from overgrowth of the basal portion of the ligament by bone, which occurs slowly under normal conditions (Johnson, 1986) but may be accelerated during hypofunction.…”

Section: Discussionmentioning

confidence: 99%

Effect of altered occlusal function on transseptal ligament and new bone thicknesses in the periodontium of the rat

Johnson

1990

Am. J. Anat.

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Alteration of tooth function is assumed to change stress/strain on the adjacent alveolar bone and its mucoperiosteum, producing changes in morphology similar to those described for other load-bearing bones. The present study suggested that crestal alveolar bone and its mucoperiosteum respond differently to stress/strain than load-bearing bones in other locations, possibly due to differences in the mechanism of bone loading by muscles and teeth. Occlusal hypofunction was initiated by extraction of agonist teeth; the contralateral teeth were placed in hyperfunction by the surgery. Untreated animals were also studied. 3H-proline was injected, animals were killed 1-5 weeks later, and the thicknesses of new bone and transseptal ligament were measured. After 5 weeks of altered function, total thickness (new bone + transseptal ligament) was similar in untreated and in hypofunctional and hyperfunctional situations; however, a new ratio between transseptal ligament and new bone thicknesses was established. Occlusal force was negatively correlated with new bone and positively correlated with transseptal ligament thickness; both thicknesses were statistically correlated in each functional situation (P less than 0.001). Hyperfunction resulted in increased transseptal ligament thickness, but decreased new bone thickness as compared to untreated controls (P less than 0.001). In contrast, hypofunction resulted in an increased new bone thickness, but a decreased transseptal ligament thickness (P less than 0.001). Tissue responses assure appropriate support for the teeth in each functional situation.

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Collagen Phagocytosis by Fibroblasts in the Periodontal Ligament of the Mouse Molar During the Initial Phase of Hypofunction

Cited by 22 publications

References 16 publications

Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla

Influence of masticatory hypofunction on the alveolar bone and the molar periodontal ligament space in the rat maxilla

Ankylosis of the mouse molar after systemic administration of 1‐hydroxyethylidene‐1,1‐bisphosphonate (HEBP)

Effect of altered occlusal function on transseptal ligament and new bone thicknesses in the periodontium of the rat

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