Collagen of brain microvessel preparations

Faris, Barbara; Mozzicato, Patricia; Ferrera, Rocco; Glembourtt, Michael; Toselli, Paul; Franzblau, Carl

doi:10.1016/0026-2862(82)90062-0

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…One MMP, MMP-12, is an elastin-degrading proteinase, with a 54-kDa proenzyme that is processed into a 45-kDa active form (Matsumoto et al, 1998). Elastin, which accounts for up to 4% of the ECM of brain microvessels (Faris et al, 1982), contains two cysteine residues that may be important for the protein's interaction with other ECM components (Rosenbloom, 1984). The elastic properties of many tissues, such as the lung, dermis and large blood vessels, are attributable to the presence of elastin fibres in the extracellular space (Rosenbloom, 1984).…”

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confidence: 99%

Elevated concentrations of matrix metalloproteinase-12 and elastin degradation products in the sera of pregnant women infected withToxoplasma gondii

2011

Annals of Tropical Medicine & Parasitology

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Although the expression of matrix metalloproteinase-12 (MMP-12) appears to be increased in most inflammatory diseases, the role of this enzyme in the pathogenesis of toxoplasmosis in pregnant women, if any, is unknown. In a recent study in Taiwan, the serum concentrations of MMP-12 and its substrate elastin were evaluated in pregnant women with Toxoplasma gondii infection. Compared with the healthy pregnant and non-pregnant women used as controls, the pregnant women with toxoplasmosis had significantly higher serum concentrations of MMP-12 and significantly higher levels of elastin synthesis and degradation. Interaction between MMP-12 and elastin in the serum samples was confirmed by co-immunoprecipitation. It seems possible that MMP-12 may contribute to elastin degradation occurring during the pathogenesis of toxoplasmosis in pregnant women.

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confidence: 99%

Elevated concentrations of matrix metalloproteinase-12 and elastin degradation products in the sera of pregnant women infected withToxoplasma gondii

2011

Annals of Tropical Medicine & Parasitology

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Recent advances in understanding brain capillary function

Goldstein

Betz

1983

Annals of Neurology

102

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The endothelial cells in brain capillaries form a blood-brain barrier which limits and controls the movement of solutes between blood and brain. These cells contain continuous tight junctions and exhibit a low rate of pinocytosis, resulting in formation of a permeability barrier to macromolecules and many polar compounds. However, brain capillary endothelial cells also contain specialized transport systems that facilitate blood-to-brain transfer of some solutes and actively pump other solutes from brian to blood. Several investigators have developed methods to isolate microvessels from brain or to grow brain capillary endothelial cells in tissue culture. This review summarizes progress made with these model systems and discusses their usefulness in increasing our knowledge of brain capillary function.

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