Collagen (NeuraGen®) nerve conduits and stem cells for peripheral nerve gap repair

Summa, Pietro G. di; Kingham, Paul J.; Campisi, C.; Raffoul, Wassim; Kalbermatten, Daniel F.

doi:10.1016/j.neulet.2014.04.029

Cited by 73 publications

(40 citation statements)

References 23 publications

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“…These methods refinements might be important to differentiate the regenerative potential of different scaffolds used, that are not evident when using the traditional standardized methods previously referred [9,66] . The recent published paper by di Summa et al [67] where collagen tube-guides (Neurogen ® ) were used in vivo to promote peripheral nerve regeneration, combined with schwann cells (SCs), it was possible to demonstrate an improved distal stump sprouting [68] . This sprouting was more pronounced in the experimental group where the SCs were derived from BM-MSCs when compared to SCs derived from adipose tissue MSCs (AT-MSCs).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Ribeiro¹,

Pereira²,

Caseiro³

et al. 2015

WJSC

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Section: Discussionmentioning

confidence: 99%

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Ribeiro¹,

Pereira²,

Caseiro³

et al. 2015

WJSC

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“…In fact, perspectives for future research on neurotubes 19,20 are very promising, with more suitable and less expensive materials that will become easily available and produce better functional results, in addition to new medications that will be developed to promote neural regeneration and prevent iatrogenic effects.…”

Section: Discussionmentioning

confidence: 99%

Combined polyglycolic acid tube and autografting versus autografting or polyglycolic acid tube alone. A comparative study of peripheral nerve regeneration in rats

Costa

Teixeira²,

Longo

et al. 2015

Acta Cir. Bras.

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PURPOSE:To compare sciatic nerve regeneration in rats using three different techniques of repair. METHODS:Fifteen isogonics rats were divided into three groups according to the method used to repair a 5-mm long defect created in the sciatic nerve: autogenous graft (Group A), polyglycolic acid tube (PGAt) (Group B), and of the association of PGAt with the graft (Group C). Histological analysis, regenerated myelinated axon number count and functional analysis were used to compare after six weeks. RESULTS:There was no difference in fiber diameter and degree of myelinization presented by Groups A, B and C. Group B presented the lowest number of regenerated axons. The groups did not display any significant functional difference after walking track analysis (p<0.05). CONCLUSION:No differences between the three groups in terms of functional recovery, although there were histological differences among them.

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“…Other sources of stem cells have been used in peripheral nerve injuries, such as adipose-derived stem cells [203,206,212,[226][227][228][229][230][231] and dental pulp stem cells (DPSCs) [232][233][234][235][236]. Dental pulp stem cells have also demonstrated differentiation capacity towards multiple other mesodermal and endodermal lineages, under appropriate conditions: adipogenic, osteo/dentinogenic, chondrogenic, neurogenic, endothelial, myofibroblastic [237] and hepatocytes [238].…”

Section: Cellular Systemsmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

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Collagen (NeuraGen®) nerve conduits and stem cells for peripheral nerve gap repair

Cited by 73 publications

References 23 publications

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells

Combined polyglycolic acid tube and autografting versus autografting or polyglycolic acid tube alone. A comparative study of peripheral nerve regeneration in rats

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

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