Collagen/Nano-hydroxyapatite Composite Scaffold Application with Exchange Reamed Nailing Accelerates Bone Union and Improves Quality of Life in Atrophic Femoral Shaft Nonunions: A Retrospective Comparative Study

Gönder, Nevzat; Demir, İbrahim; Öğümsöğütlü, Erman; Kılınçoğlu, Volkan

doi:10.1007/s43465-021-00545-9

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…It is a bone repair material that works on the principle of in situ biomimetic mineralization and molecular self-assembly technology, which can simulate the composition and hierarchical structure of natural bones. It exhibits a good biocompatibility, bone conductivity, and biological activity, provides a suitable cellular microenvironment for bone regeneration, and has applications in bone defect repair [8][9][10][11][12]. However, the mechanical properties of simple MC scaffolds are limited and need to meet the high mechanical strength and dynamic property requirements for bone repair materials [13].…”

Section: Introductionmentioning

confidence: 99%

Mineralized Collagen/Polylactic Acid Composite Scaffolds for Load-Bearing Bone Regeneration in a Developmental Model

Zhu,

Li,

Yao

et al. 2023

Polymers

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Repairing load-bearing bone defects in children remains a big clinical challenge. Mineralized collagen (MC) can effectively simulate natural bone composition and hierarchical structure and has a good biocompatibility and bone conductivity. Polylactic acid (PLA) is regarded as a gold material because of its mechanical properties and degradability. In this study, we prepare MC/PLA composite scaffolds via in situ mineralization and freeze-drying. Cell, characterization, and animal experiments compare and evaluate the biomimetic properties and repair effects of the MC/PLA scaffolds. Phalloidin and DAPI staining results show that the MC/PLA scaffolds are not cytotoxic. CCK-8 and scratch experiments prove that the scaffolds are superior to MC and hydroxyapatite (HA)/PLA scaffolds in promoting cell proliferation and migration. The surface and interior of the MC/PLA scaffolds exhibit rich interconnected pore structures with a porosity of ≥70%. The XRD patterns are typical HA waveforms. X-ray, micro-CT, and H&E staining reveal that the defect boundary disappears, new bone tissue grows into MC/PLA scaffolds in a large area, and the scaffolds are degraded after six months of implantation. The MC/PLA composite scaffold has a pore structure and composition similar to cancellous bone, with a good biocompatibility and bone regeneration ability.

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Section: Introductionmentioning

confidence: 99%

Mineralized Collagen/Polylactic Acid Composite Scaffolds for Load-Bearing Bone Regeneration in a Developmental Model

Zhu,

Li,

Yao

et al. 2023

Polymers

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show abstract

“…MC is also used in the repair of appendicular skeleton defects. Nevzat et al [ 93 ] evaluated the clinical and functional outcomes of using a collagen/n-HA composite scaffold for atrophic bone non-union, and showed that the composite scaffold improved the healing rate of atrophic bone non-union of the femoral stem. Therefore, MC can be widely used in the repair of bone defects.…”

Section: Current Status Of MC and Its Application Of Related Absorbab...mentioning

confidence: 99%

Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair

Zhu

Yao

et al. 2023

Regenerative Biomaterials

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At this stage, bone defects caused by trauma, infection, tumor, or congenital diseases are generally filled with autologous bone or allogeneic bone transplantation, but this treatment method has limited sources, potential disease transmission, and other problems. Ideal bone graft materials remain continuously explored, and bone defect reconstruction remains a significant challenge. Mineralized collagen prepared by bionic mineralization combining organic polymer collagen with inorganic mineral calcium phosphate can effectively imitate the composition and hierarchical structure of natural bone and has good application value in bone repair materials. Magnesium, strontium, zinc, and other inorganic components not only can activate relevant signaling pathways to induce differentiation of osteogenic precursor cells, but also stimulate other core biological processes of bone tissue growth and play an important role in natural bone growth, and bone repair and reconstruction. This study reviewed the advances in hydroxyapatite/collagen composite scaffolds and osseointegration with natural bone inorganic components such as magnesium, strontium, and zinc.

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The Impact of Bone Marrow Venting Augmentation on Knee Functions in the Repair of Vertical/Longitudinal Meniscus Tears: A Triple Comparison

Demir,

Karslı

2024

JOIO

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Collagen/Nano-hydroxyapatite Composite Scaffold Application with Exchange Reamed Nailing Accelerates Bone Union and Improves Quality of Life in Atrophic Femoral Shaft Nonunions: A Retrospective Comparative Study

Cited by 4 publications

References 41 publications

Mineralized Collagen/Polylactic Acid Composite Scaffolds for Load-Bearing Bone Regeneration in a Developmental Model

Mineralized Collagen/Polylactic Acid Composite Scaffolds for Load-Bearing Bone Regeneration in a Developmental Model

Advances in osseointegration of biomimetic mineralized collagen and inorganic metal elements of natural bone for bone repair

The Impact of Bone Marrow Venting Augmentation on Knee Functions in the Repair of Vertical/Longitudinal Meniscus Tears: A Triple Comparison

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