Collagen mutation and age contribute to differential craniofacial phenotypes in mouse models of osteogenesis imperfecta
Hsiao H Sung,
Wyatt J Spresser,
Joseph P Hoffmann
et al.
Abstract:Craniofacial and dentoalveolar abnormalities are present in all types of Osteogenesis Imperfecta (OI). Mouse models of the disorder are critical to understanding these abnormalities and underlying OI pathogenesis. Previous studies on severely affected OI mice report a broad spectrum of craniofacial phenotypes, exhibiting some similarities to the human disorder. Brtl/+ and G610c/+ are moderately severe and mild type IV OI, respectively. Little is known about the aging effects on the craniofacial bones of these … Show more
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