Collagen Isotypes, Laminin, and Fibronectin in Granulomas of the Liver and Intestines of Schistosoma Mansoni-Infected Mice

Ja, Grimaud; Boros, Dov L.; Takiya, Christina Maeda; Mathew, R C; Emonard, Hervé

doi:10.4269/ajtmh.1987.37.335

Cited by 37 publications

(33 citation statements)

References 28 publications

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“…Present findings confirm and extend previous data which are suggestive that the so-called "immunological modulation" of schistosomal periovular granuloma is a morphological phenomenom peculiar to the liver (Grimaud et al 1987, Vidal et al 1992. Granulomas formed around eggs injected directly into the lungs (Lichtenberg 1962) or liver (Edungbola & Schiller 1979) differ accordingly with the previous immunological state of the host, that is, whether the recipient animal is already S. mansoni infected or not.…”

Section: Discussionsupporting

confidence: 82%

Significance of schistosomal granuloma modulation

Silva

Fernandes

Barbosa

et al. 2000

Mem. Inst. Oswaldo Cruz

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Key words: modulation -granuloma -shistosomiasis -extracellular matrix Hepatic granulomas formed around mature eggs of Schistosoma mansoni undergo changes in size, appearance and cellular constitution with time. This has been interpreted as a mechanism of host protection, with the host reactions becoming more economical and efficient during chronic infection (Andrade & Warren 1964). The immunological counterpart has been thoroughly investigated, both in vivo (Colley 1981, Chensue et al. 1993, Bogen et al. 1995 and in vitro (Doughty & Phillips 1982, Parra et al. 1991, including its cytokine patterns , McKerrow 1997. However, there are data indicating that granulomas outside the liver may behave differently. Granulomas in the intestine were observed to be already modulated in the ileum from the very beginning, although modulation was said to occur in the colon and ileal Peyer's patch (Weinstock & Boros 1981, 1983 the same morphology regardless the time of infection (Vidal et al. 1992, Eltoum et al. 1995. Such findings suggest that the so-called "immunological modulation" of periovular granulomas in schistosomiasis is mainly influenced by local factors. If this is so, the current interpretation of the immunological modulation concept needs to be revised.To further investigate this possibility, a comparative study of size, appearance and matrix composition of granulomas formed in three different organs of mice (liver, intestine and lung), during three different periods of infection (early, intermediate and late), was undertaken. Methods of histopathology, immunofluorescence, biochemistry and morphometry were applied in an attempt to understand the real significance of the so-called "immunological modulation" of schistosomal granuloma. MATERIALS AND METHODSThrity-one albino Swiss mice of both sexes, weighing 18-23 g, maintained with free access to a commercial balanced diet and water, were used. Animals were submitted to transcutaneous infection with 50 recently eliminated S. mansoni cercariae each. Later, animals were randomly divided into three groups, according to time of infection: first group (acute phase), animals sacrificed eight

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Section: Discussionsupporting

confidence: 82%

Significance of schistosomal granuloma modulation

Silva

Fernandes

Barbosa

et al. 2000

Mem. Inst. Oswaldo Cruz

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“…IFN-␥ is typically regarded as a marker of a proinflammatory cytokine environment, but it has also exhibited antifibrotic activity by interfering with transforming growth factor ␤ signaling and directly down-regulating collagen synthesis (3,9,12). Because the evolving, chronic schistosome infection results in incremental liver fibrosis (15) and there is significantly less IFN-␥ production in WSX-1 Ϫ/Ϫ mice, we examined 24-week-infected WSX-1 Ϫ/Ϫ and BL/6 mice for possible differences in overall immunopathology and cytokine production, including production of IL-13, which is a mediator of fibrosis (8,13). Early death of SEA/CFA-immunized mice at 7 to 8 weeks postinfection, which was not significantly different for WSX-1 Ϫ/Ϫ and BL/6 mice, restricted the study to the unimmunized groups.…”

Section: Resultsmentioning

confidence: 99%

Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection

et al. 2007

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“…Compared with the hepatic granulomas, much less collagen was deposited in the ileal or colonic granulomas. In the immunomodulated colonic lesions, the amount of the type III collagen was higher than that of type I (149).…”

Section: Egg-induced Granulomatous Pathologymentioning

confidence: 99%

Immunopathology of Schistosoma mansoni infection

1989

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Schistosomiasis mansoni is a chronic helminthic disease that affects about 100 million people in the tropics. The worms have a life span of 5 to 10 years, and they live in the mesenteric veins of the host. Lightly infected individuals are asymptomatic or manifest mild intestinal symptoms. Heavily infected individuals often develop severe morbidity with hepatosplenomegaly, sometimes with a fatal outcome. Morbidity is attributed to the strong humoral and T-cell-mediated host immune responses developed to a variety of parasite antigens and expressed as tissue inflammations. The immunopathology includes dermatitis, immune complex-mediated kidney disease, and, chiefly, T-cell-mediated granuloma formation and fibrosis around disseminated parasite eggs. This review describes the mechanisms of induction and expression of immunopathology in infected persons and experimental animals. Immunoregulatory mechanisms that modulate the enhanced immune responses and may ameliorate excessive morbidity are discussed.

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Collagen Isotypes, Laminin, and Fibronectin in Granulomas of the Liver and Intestines of Schistosoma Mansoni-Infected Mice

Cited by 37 publications

References 28 publications

Significance of schistosomal granuloma modulation

Significance of schistosomal granuloma modulation

Disruption of Interleukin-27 Signaling Results in Impaired Gamma Interferon Production but Does Not Significantly Affect Immunopathology in Murine Schistosome Infection

Immunopathology of Schistosoma mansoni infection

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