Collagen-Induced Arthritis in DBA/1 Mice: Cytokine Gene Activation Following Immunization with Type II Collagen

Stasiuk, Lisa M.; Abehsira‐Amar, Orly; Fournier, Catherine

doi:10.1006/cimm.1996.0277

Cited by 35 publications

(29 citation statements)

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“…This finding is similar to the results observed in experimental allergic encephalomyelitis induced with myelin proteins in mycobacterium-containing adjuvant [23]. Mycobacterium adjuvant induces a strong immune response leading to a cytokine environment favoring a Th1 differentiation of antigen-specific T cells [24], which could explain why classically CIA has been suggested to be a Th1-driven disease with IL-4 having a protective role. On the other hand, arthritis induced by CII immunization in mineral oil without mycobacterium presents an opportunity to analyze the actual role of endogenous IL-4 without skewing the immune response.…”

Section: Discussionsupporting

confidence: 88%

IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis

et al. 2002

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Section: Discussionsupporting

confidence: 88%

IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis

et al. 2002

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“…Other experimental animal models of rheumatoid arthritis include rat collagen-induced arthritis model (Kaklamarius, 1992;Stasiuk et al, 1996;Vierboom et al, 2005), mouse collagen-induced arthritis (Boissier et al, 1987;Campbell et al, 2000;Brand et al, 2007) and mouse collagen antibody-induced arthritis models (Brand, 2005). Inoculation of animals with CFA (which was prepared by suspending heat-killed Mycobacterium butyricum in liquid paraffin at a dose of 10 mg/ml Mycobacterium butyricum in paraffin oil), is known to produce a profound systemic inflammation resulting in severe joint swelling and remodeling (Omoto et al, 2005) and this is usually characterized by mechanical allodynia, thermal hyperalgesia and pain on joint movement (joint hyperalgesia) (Tatsuo et al, 1994;Jasmin et al, 1998;Bertorelli et al, 1999;Nagakura et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Evaluation Of The Anti-Arthritic Activity Of The Hydroethanolic Leaf Extract Of <i>Alchornea Cordifolia</i> In Rats

Adeneye¹,

Oreagba²,

Ishola³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Different decoctions of Alchornea cordifolia leaves are used by Yoruba herbalists (Southwest Nigeria) for the local treatment of ulcers, rheumatic pains, febrile convulsions, and for enhancing physical performance. Materials and methods: In this study, the anti-arthritic effect of 100 -400 mg/kg/day of the hydroethanolic leaf extract of Alchornea cordifolia (HEAC) was investigated in Complete Freund's Adjuvant (CFA)-induced arthritic rats as a way of evaluating its efficacy in the local management of arthritis. In addition, the effects of HEAC on liver and renal function parameters as well as its effect on the antioxidant enzyme system were investigated. Arthritis was induced using 0.1 ml of 10 mg/ml of Complete Freund's Adjuvant (CFA) following 1 h oral pretreatment and 8 th day postarthritic induction with 100, 200 and 400 mg/kg/day of HEAC and 3 mg/kg/day of celecoxib as the reference drug. The anti-arthritic activity of HEAC was assessed based on the ability of HEAC to alter the paw edema diameter, body weight, full blood count, renal and liver function markers, glycoprotein, lysosomal enzymes and possible antioxidant potential in the arthritic rats. Results: Oral pretreatment with 100, 200, and 400 mg/kg/day of HEAC produced significant (p<0.001, p<0.05 and p<0.01) reductions in the paw edema diameter in a non-dose dependent fashion in ACF-induced arthritic rats with the 100 mg/kg/day of HEAC producing the most significant antiarthritic effect. Similarly, HEAC increased hepatic GSH levels, CAT and SOD activities suggesting possible antioxidant mechanism for its antiarthritic effect. Conclusion: Overall, results of this study lend credence to the folkloric use of water decoction of Alchornea cordifolia leaves against rheumatoid arthritis. However, further pharmacological investigations would be required at isolating and determining the active anti-arthritic molecule(s) in HEAC in the nearest future.

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“…It is unlikely that in an immunocompetent animal the transplanted xenogeneic cells would be tolerated for long periods but it is possible that the transient production of IL-4 or IL-13 early on was sufficient to alter the developing Th1 like T cell response. In addition, other experimental treatments for CIA such as the use of nondepleting anti-CD4 antibodies 61 or priming with CII in Freund's incomplete adjuvant 8,62 have been suggested to exert their ameliorating effect by stimulating preferentially the development of Th2 cells and production of Th2 cytokines. However, unlike the studies reported here, none of these experiments were performed in animals with established and inflammatory arthritis.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of established collagen induced arthritis by systemic IL-10 gene delivery

Fellowes¹,

Etheridge

Coade³

et al. 2000

Gene Ther

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Collagen-Induced Arthritis in DBA/1 Mice: Cytokine Gene Activation Following Immunization with Type II Collagen

Cited by 35 publications

References 0 publications

IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis

IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis

Evaluation Of The Anti-Arthritic Activity Of The Hydroethanolic Leaf Extract Of <i>Alchornea Cordifolia</i> In Rats

Amelioration of established collagen induced arthritis by systemic IL-10 gene delivery

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