Collagen in Wound Healing

Mathew-Steiner, Shomita S.; Roy, Sashwati; Sen, Chandan K.

doi:10.3390/bioengineering8050063

Cited by 440 publications

(377 citation statements)

References 130 publications

(213 reference statements)

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“…Type III collagen is mainly synthesized in the early stages of wound healing, but eventually, it is replaced by type I—the dominant fibrillar collagen in the skin. During ECM reorganization, these components are specifically cleaved by MMP-1, MMP-8, and for final collagen maturation, it is modified by lysyl oxidase (LOX), resulting in covalent cross-linking and restoration of tensile strength [ 129 ]. Unsurprisingly, fibroblast-derived EVs contribute to ECM reorganization by increasing collagen I, MMP-1, and MMP-3 gene expression ( p < 0.01) in other fibroblasts.…”

Section: The Role Of Extracellular Vesicles In Natural Wound Repairmentioning

confidence: 99%

Extracellular Vesicles in Skin Wound Healing

et al. 2021

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Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or injuries accompanied by an infection. For these cases, scientists are searching for new therapeutic interventions, from which one of the most promising is the use of extracellular vesicles (EVs). Naturally, EV-based signaling takes part in all four wound healing phases: hemostasis, inflammation, proliferation, and remodeling. Such an extensive involvement of EVs suggests exploiting their action to modulate the impaired healing phase. Furthermore, next to their natural wound healing capacity, EVs can be engineered for better defined pharmaceutical purposes, such as carrying specific cargo or targeting specific destinations by labelling them with certain surface proteins. This review aims to promote scientific awareness in basic and translational research of EVs by summarizing the current knowledge about their natural role in each stage of skin repair and the most recent findings in application areas, such as wound healing, skin regeneration, and treatment of dermal diseases, including the stem cell-derived, plant-derived, and engineered EVs.

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Section: The Role Of Extracellular Vesicles In Natural Wound Repairmentioning

confidence: 99%

Extracellular Vesicles in Skin Wound Healing

et al. 2021

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“…Inflammation occurs as a result of the inflammatory response of keratinocytes (at the edge of the wound), cytokines, and growth factors during thermal and cellular processes. The cells involved are leukocytes and fibroblasts [ 19 , 20 , 21 ]. Leukocytes (polymorphonuclear leukocytes-PMN, macrophages, lymphocytes) secrete biomarkers such as IL-1, IL-6, TNF-α, with role for the maintenance of inflammation.…”

Section: Chronic Wounds Mechanisms and Alginates Rolesmentioning

confidence: 99%

Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds

Barbu

Neamţu

Zăhan

et al. 2021

JPM

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Chronic wounds represent a major public health issue, with an extremely high cost worldwide. In healthy individuals, the wound healing process takes place in different stages: inflammation, cell proliferation (fibroblasts and keratinocytes of the dermis), and finally remodeling of the extracellular matrix (equilibrium between metalloproteinases and their inhibitors). In chronic wounds, the chronic inflammation favors exudate persistence and bacterial film has a special importance in the dynamics of chronic inflammation in wounds that do not heal. Recent advances in biopolymer-based materials for wound healing highlight the performance of specific alginate forms. An ideal wound dressing should be adherent to the wound surface and not to the wound bed, it should also be non-antigenic, biocompatible, semi-permeable, biodegradable, elastic but resistant, and cost-effective. It has to give protection against bacterial, infectious, mechanical, and thermal agents, to modulate the level of wound moisture, and to entrap and deliver drugs or other molecules This paper explores the roles of alginates in advanced wound-dressing forms with a particular emphasis on hydrogels, nanofibers networks, 3D-scaffolds or sponges entrapping fibroblasts, keratinocytes, or drugs to be released on the wound-bed. The latest research reports are presented and supported with in vitro and in vivo studies from the current literature.

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“…In this study, we compared the effects of BC scaffold and collagen total type material (COLt) on M1/M2 macrophage phenotypes by analyzing the expression of iNOS and Arg-1, as well as M1/M2 macrophage-related cytokines. Collagen, one of the primary components of ECM, is commonly used as a dressing-based material in wound healing because it can promote angiogenesis and re-epithelialization of wound tissue [51]. In the subsequent experiment, we compared BC scaffold effectiveness to that of collagen-based material, which served as a control dressing, to explore any differences in the regulation of the skin wound inflammation response.…”

Section: Immunoregulation Of Bacterial Cellulose Scaffold On Macrophage Behaviormentioning

confidence: 99%

Bacterial Cellulose as a Potential Bio-Scaffold for Effective Re-Epithelialization Therapy

et al. 2021

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Currently, there are several therapeutic approaches available for wound injury management. However, a better understanding of the underlying mechanisms of how biomaterials affect cell behavior is needed to develop potential repair strategies. Bacterial cellulose (BC) is a bacteria-produced biopolymer with several advantageous qualities for skin tissue engineering. The aim here was to investigate BC-based scaffold on epithelial regeneration and wound healing by examining its effects on the expression of scavenger receptor-A (SR-A) and underlying macrophage behavior. Full-thickness skin wounds were generated on Sprague-Dawley rats and the healing of these wounds, with and without BC scaffolds, was examined over 14 days using Masson’s trichome staining. BC scaffolds displayed excellent in vitro biocompatibility, maintained the stemness function of cells and promoted keratinocyte differentiation of cells, which are vital in maintaining and restoring the injured epidermis. BC scaffolds also exhibited positive in vivo effects on the wound microenvironment, including improved skin extracellular matrix deposition and controlled excessive inflammation by reduction of SR-A expression. Furthermore, BC scaffold significantly enhanced epithelialization by stimulating the balance of M1/M2 macrophage re-programming for beneficial tissue repair relative to that of collagen material. These findings suggest that BC-based materials are promising products for skin injury repair.

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Collagen in Wound Healing

Cited by 440 publications

References 130 publications

Extracellular Vesicles in Skin Wound Healing

Extracellular Vesicles in Skin Wound Healing

Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds

Bacterial Cellulose as a Potential Bio-Scaffold for Effective Re-Epithelialization Therapy

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