Collagen in the Heart of Wild and Domesticated Animals

Chvapil, Miloš; Rakusan, K; Wachtlová, M; Poupa, O

doi:10.1159/000211546

Cited by 10 publications

(6 citation statements)

References 3 publications

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“…(1972) found a definite increase in hydroxyproline content in the rat heart with age . Chvapil et al (1966) also showed that the collagen content was higher in the right ventricle of younger rats than in the left ventricle. Thus, there were many papers which reported no changes of collagen in the human heart muscle but an increase of collagen in animal hearts with aging.…”

Section: Discussionmentioning

confidence: 83%

“…On the other hand, von Knorring (1970) , studying collagen contents in rats aged 1 day to 18 months, found no changes in collagen content in the heart up to 3 postnatal weeks, but thereafter a slight increase with age . In addition, Schaub (1964/65), Chvapil et al (1966) and Tomanek et al . (1972) found a definite increase in hydroxyproline content in the rat heart with age .…”

Section: Discussionmentioning

confidence: 97%

“…In contrast, von Knorring (1970) has found that a slight increase in collagen concentration with age takes place in the rat heart after 3 postnatal weeks, althoughthe collagen concentration remains almost constant. In addition, Schaub (1964/65), Chvapil et al (1966) and Tomanek et al (1972) reported the increase in collagen with age in the rat heart.…”

mentioning

confidence: 97%

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Aging and Hydroxyproline Content in Human Heart Muscle

Sasaki

Ichikawa

Yamagiwa

et al. 1976

Tohoku J. Exp. Med.

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Hydroxyproline content was chemically determined in 45 human hearts obtained at autopsy, in order to know possible correlations between aging and hydroxyproline content in the heart muscle. There were no significant differences in the mean total hydroxyproline content between the epicardium and the endocardium, between left and right ventricles, nor between young, middle and old age groups.The hydroxyproline content in NaCl-soluble fraction decreased, and that in TCA-soluble fraction and in residue fraction increased with age. There were significant differences in the mean hydroxy proline content in NaCl-soluble fraction between middle and old age groups, and in residue fraction between young and old age groups in the endocardium of the left ventricle.Accordingly, the ratio of the content in NaCl-soluble fraction to that in TCA-soluble fraction decreases with age. This tendency was more evident in the epicardium than in the endocardium on the left ventricle.These results indicate that total hydroxyproline content per 1 mg of lyophilized material does not show any quantitative changes, but does show qualitative changes with age-aging; hydroxyrpoline; heart

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 97%

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Aging and Hydroxyproline Content in Human Heart Muscle

Sasaki

Ichikawa

Yamagiwa

et al. 1976

Tohoku J. Exp. Med.

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“…Oken and Boucek (1) stated that the right ventricle has a significantly higher concentration of collagen than does the left ventricle in the normal human heart. Chvapil et al (7) also reported that the collagen content was higher in the right ventricle of younger rats than in the left ventricle. The present study, however, shows no significant differences of hydroxyproline content in each fraction between the left and right ventricle.…”

Section: Discussionmentioning

confidence: 92%

“…The findings in animal hearts are also conflicting. For the rat heart, three studies (6)(7)(8) showed an increase in collagen with aging, but two others (9,10) indicated no change. For the dog heart, one study (11) demonstrated an increase in collagen with aging.…”

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confidence: 99%

Effects of Aging on Hydroxyproline in Human Heart Muscle

Ito

Yamagiwa

Sasaki

1980

J American Geriatrics Society

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Hydroxyproline concentration in the NaCl-soluble, TCA-soluble, and residual fractions of heart muscle was chemically determined in 40 autopsy subjects (25 men and 15 women), to study the effects of aging. In the left ventricle, the total hydroxyproline content of the endocardium and papillary muscle increased significantly in relation to age; the increase was greatest in the TCA-soluble fraction, followed by the residual fraction. Statistical analysis revealed that hydroxyproline in the residual fraction increased from the epicardium to the endocardium and then to the papillary muscle. Significant negative correlations were found between heart weight and total hydroxyproline in the epicardium and endocardium. In the right ventricle, a significant negative correlation was noted between heart weight and total hydroxyproline content. Though no correlations were evident between age and hydroxyproline content in females, significant correlations were observed between age and the total hydroxyproline content of the endocardium and papillary muscle in males. Furthermore, soluble collagen increased in most parts of the heart in females, but insoluble collagen increased in all parts of the heart in males. It is concluded that the hydroxyproline content of heart muscle increases in proportion to age and is in inverse proportion to heart weight. The increase occurs in the TCA-soluble and residual fractions, and extends from the endocardium to the papillary muscle. More profound changes in collagen metabolism are observed in males.

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