Collagen–Hydroxypropyl Methylcellulose Membranes for Corneal Regeneration

Long, Yuyu; Zhao, Xuan; Liu, Sa; Chen, Min; Liu, Bingqian; Ge, Jian; Jia, Yong‐Guang; Li, Ren

doi:10.1021/acsomega.7b01511

Cited by 31 publications

(21 citation statements)

References 38 publications

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“…Until now, most studies have worked on introducing new materials and biochemical approaches in cornea wound healing and regeneration; while paying attention to physical properties of these approaches might be a leap in this area. For instance Long et al have tried to use a cross-linking agent in collagen membrane to regulate collagen fibril spacing and therefore improve optical clarity of collagen and increase permeability of neurites (Long et al, 2018). Hence, advances in visualization techniques will help to improve corneal physical structure identification that, in combination with material science, will lead to new sights in the typical treatment approaches.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Corneal Repair and Regeneration: Current Concepts and Future Directions

Mobaraki

Abbasi

Vandchali

et al. 2019

Front. Bioeng. Biotechnol.

117

109

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The cornea is a unique tissue and the most powerful focusing element of the eye, known as a window to the eye. Infectious or non-infectious diseases might cause severe visual impairments that need medical intervention to restore patients' vision. The most prominent characteristics of the cornea are its mechanical strength and transparency, which are indeed the most important criteria considerations when reconstructing the injured cornea. Corneal strength comes from about 200 collagen lamellae which criss-cross the cornea in different directions and comprise nearly 90% of the thickness of the cornea. Regarding corneal transparency, the specific characteristics of the cornea include its immune and angiogenic privilege besides its limbus zone. On the other hand, angiogenic privilege involves several active cascades in which anti-angiogenic factors are produced to compensate for the enhanced production of proangiogenic factors after wound healing. Limbus of the cornea forms a border between the corneal and conjunctival epithelium, and its limbal stem cells (LSCs) are essential in maintenance and repair of the adult cornea through its support of corneal epithelial tissue repair and regeneration. As a result, the main factors which threaten the corneal clarity are inflammatory reactions, neovascularization, and limbal deficiency. In fact, the influx of inflammatory cells causes scar formation and destruction of the limbus zone. Current studies about wound healing treatment focus on corneal characteristics such as the immune response, angiogenesis, and cell signaling. In this review, studied topics related to wound healing and new approaches in cornea regeneration, which are mostly related to the criteria mentioned above, will be discussed.

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Section: Conclusion and Future Outlookmentioning

confidence: 99%

Corneal Repair and Regeneration: Current Concepts and Future Directions

Mobaraki

Abbasi

Vandchali

et al. 2019

Front. Bioeng. Biotechnol.

117

109

View full text Add to dashboard Cite

show abstract

“…In reference to Zhang et al [3], the authors proposed a type I collagen sponge obtained from rat tail as a substitute for corneal tissue. Long et al evaluated collagen-hydroxypropyl methylcellulose membranes, which had optical properties equivalent to human corneas [57].…”

Section: Ophthalmologic Insertsmentioning

confidence: 99%

Tilapia (Oreochromis aureus) Collagen for Medical Biomaterials

Valenzuela-Rojo¹,

López‐Cervantes²,

Sánchez‐Machado³

2018

Seaweed Biomaterials

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Collagen is a natural polymer widely used in pharmaceutical products and nutritional supplement due to its biocompatibility and biodegradability. Collagen is a fibrous protein that supports various tissues, and its primary structure is formed by repeated units of glycineproline-hydroxyproline. Traditional sources of collagen, such as bovine and pig skins or chicken waste, limit their use due to the dangers of animal-borne diseases. Thus, marine animals are an alternative for the extraction of collagen. The common name of Oreochromis aureus is tilapia, widely cultivated for sale as frozen fillets. During its processing, a large amount of collagen-rich wastes are generated. Therefore, the objective of this book chapter is to prove the potential of tilapia skin as an alternative source of collagen for the elaboration of biomaterials. Additionally to the literature review, experimental results of the extraction and characterization of tilapia skin collagen for use in medical dressings are presented.

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“…Moreover, interlamellar transplantation was applied to investigate the regenerative properties of the collagen and HPMC composite in rabbit models. Keratocyte cells repopulated the hydrogels, and the clear cornea was observed after 6 months [113].…”

Section: 222mentioning

confidence: 97%

Bioengineering Approaches for Corneal Regenerative Medicine

Mahdavi

Abdekhodaie

Mashayekhan

et al. 2020

Tissue Eng Regen Med

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BACKGROUND: Since the cornea is responsible for transmitting and focusing light into the eye, injury or pathology affecting any layer of the cornea can cause a detrimental effect on visual acuity. Aging is also a reason for corneal degeneration. Depending on the level of the injury, conservative therapies and donor tissue transplantation are the most common treatments for corneal diseases. Not only is there a lack of donor tissue and risk of infection/rejection, but the inherent ability of corneal cells and layers to regenerate has led to research in regenerative approaches and treatments. METHODS: In this review, we first discussed the anatomy of the cornea and the required properties for reconstructing layers of the cornea. Regenerative approaches are divided into two main categories; using direct cell/growth factor delivery or using scaffold-based cell delivery. It is expected delivered cells migrate and integrate into the host tissue and restore its structure and function to restore vision. Growth factor delivery also has shown promising results for corneal surface regeneration. Scaffold-based approaches are categorized based on the type of scaffold, since it has a significant impact on the efficiency of regeneration, into the hydrogel and non-hydrogel based scaffolds. Various types of cells, biomaterials, and techniques are well covered. RESULTS: The most important characteristics to be considered for biomaterials in corneal regeneration are suitable mechanical properties, biocompatibility, biodegradability, and transparency. Moreover, a curved shape structure and spatial arrangement of the fibrils have been shown to mimic the corneal extracellular matrix for cells and enhance cell differentiation. CONCLUSION: Tissue engineering and regenerative medicine approaches showed to have promising outcomes for corneal regeneration. However, besides proper mechanical and optical properties, other factors such as appropriate sterilization method, storage, shelf life and etc. should be taken into account in order to develop an engineered cornea for clinical trials.

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Collagen–Hydroxypropyl Methylcellulose Membranes for Corneal Regeneration

Cited by 31 publications

References 38 publications

Corneal Repair and Regeneration: Current Concepts and Future Directions

Corneal Repair and Regeneration: Current Concepts and Future Directions

Tilapia (Oreochromis aureus) Collagen for Medical Biomaterials

Bioengineering Approaches for Corneal Regenerative Medicine

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