Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma

Huang, Kuo Feng; Hsu, Wei-Cherng; Hsiao, Jong‐Kai; Chen, Gunng Shinng

doi:10.1155/2014/672409

Cited by 18 publications

(21 citation statements)

References 50 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tissue engineering scaffolds offer a possible way to restore function to the brain. Scaffolds can be bare [118], or possess molecules that induce regeneration [119].…”

Section: Surgical Implantsmentioning

confidence: 99%

Scaffolds for 3D in vitro culture of neural lineage cells

et al. 2017

View full text Add to dashboard Cite

Neurodegenerative diseases, including dementia, Parkinson's and Alzheimer's diseases and motor neuron diseases, are a major societal challenge for aging populations. Understanding these conditions and developing therapies against them will require the development of new physical models of healthy and diseased neural tissue. Cellular models resembling neural tissue can be cultured in the laboratory with the help of 3D scaffolds - materials that allow the organization of neural cells into tissue-like structures. This review presents recent work on the development of different types of scaffolds for the 3D culture of neural lineage cells and the generation of functioning neural-like tissue. These in vitro culture systems are enabling the development of new approaches for modelling and tackling diseases of the brain and CNS.

show abstract

“…Tissue engineering scaffolds offer a possible way to restore function to the brain. Scaffolds can be bare [118], or possess molecules that induce regeneration [119].…”

Section: Surgical Implantsmentioning

confidence: 99%

Scaffolds for 3D in vitro culture of neural lineage cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Several studies have investigated the effects of CH on the brain. It has been reported that the ingestion of CH may help recovery from brain injury by promoting angiogenesis [22], and that CH exerts neuroprotective action by suppressing inflammatory effects [23]. A study of aged mice reported that marine CH promoted learning and memory [24].…”

Section: Introductionmentioning

confidence: 99%

Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study

Koizumi¹,

Inoue²,

Sugihara³

et al. 2019

Nutrients

View full text Add to dashboard Cite

This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49–63 years. The primary outcome measures were the brain healthcare quotients based on gray matter volume (GM-BHQ) and fractional anisotropy (FA-BHQ). The secondary outcome measures were changes in scores between week 0 and week 4 for word list memory (WLM) and standard verbal paired associate learning (S-PA) tests as well as changes in the physical, mental, and role/social component summary scores of the Short Form-36(SF-36) quality of life instrument. CH ingestion resulted in significant improvements in FA-BHQ (p = 0.0095), a measure of brain structure, as well in scores for the WLM (p = 0.0046) and S-PA (p = 0.0007) tests, which measure cognitive function. There were moderate correlations between the change in WLM score and the change in GM-BHQ (r = 0.4448; Spearman’s rank correlation) and between the change in S-PA score and the change in FA-BHQ (r = 0.4645). Daily ingestion of CH changed brain structure and improved language cognitive function.

show abstract

“…Surgical brain injury (SBI) is the inadvertent injury to brain tissue at the perisurgical site which occurs due to neurosurgical maneuvers such as incision, retraction, and electrocoagulation that can aggravate post-operative brain edema and neurological deficits (Jadhav et al, 2007a, Huang et al, 2014). Major complications are encountered in 13–27% patients after intracranial surgeries (Bruder, 2002).…”

Section: Introductionmentioning

confidence: 99%

Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model

Sherchan

Huang

Wang

et al. 2016

Neurobiology of Disease

View full text Add to dashboard Cite

Background and Purpose Peripheral immune cell infiltration to the brain tissue at the perisurgical site can promote neuroinflammation after surgical brain injury (SBI). Slit2, an extracellular matrix protein, has been reported to reduce leukocyte migration. This study evaluated the effect of recombinant Slit2 and the role of its receptor roundabout1 (Robo1) and its downstream mediator Slit-Robo GTPase activating protein 1 (srGAP1)-Cdc42 on peripheral immune cell infiltration after SBI in a rat model. Methods One hundred and fifty-three adult male Sprague-Dawley rats (280–350 g) were used. Partial resection of right frontal lobe was performed to induce SBI. Slit2 siRNA was administered by intracerebroventricular injection 24 hours before SBI. Recombinant Slit2 was injected intraperitoneally 1 hour before SBI. Recombinant Robo1 used as a decoy receptor was co-administered with recombinant Slit2. srGAP1 siRNA was administered by intracerebroventricular injection 24 hours before SBI. Post-assessments included brain water content measurement, neurological tests, ELISA, western blot, immunohistochemistry, and Cdc42 activity assay. Results Endogenous Slit2 was increased after SBI. Robo1 was expressed by peripheral immune cells. Endogenous Slit2 knockdown worsened brain edema after SBI. Recombinant Slit2 administration reduced brain edema, neurological deficits, and pro-inflammatory cytokines after SBI. Recombinant Slit2 reduced peripheral immune cell markers cluster of differentiation 45 (CD45) and myeloperoxidase (MPO), as well as Cdc42 activity in the perisurgical brain tissue which was reversed by recombinant Robo1 co-administration and srGAP1 siRNA. Conclusions Recombinant Slit2 improved outcomes by reducing neuroinflammation after SBI, possibly by decreasing peripheral immune cell infiltration to the perisurgical site through Robo1-srGAP1 mediated inhibition of Cdc42 activity. These results suggest that Slit2 may be beneficial to reduce SBI-induced neuroinflammation.

show abstract

Collagen-Glycosaminoglycan Matrix Implantation Promotes Angiogenesis following Surgical Brain Trauma

Cited by 18 publications

References 50 publications

Scaffolds for 3D in vitro culture of neural lineage cells

Scaffolds for 3D in vitro culture of neural lineage cells

Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study

Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model

Contact Info

Product

Resources

About