Collagen Genes and Exercise-Associated Muscle Cramping

Abstract

This study identified, for the first time, the COL5A1 gene as a potential marker for a history of EAMC.

The Variants Within the COL5A1 Gene are Associated with Reduced Risk of Anterior Cruciate Ligament Injury in Skiers

“…On the other hand, individuals with a wild-type CC genotype are protected against chronic degenerative changes in the Achilles tendon during running and other physical activity ( O’Connell et al, 2013 ). O’Connell et al (2013) support the hypothesis that variants within genes, such as COL5A1 , COL3A1 , COL6A1 , and COL12A1 genes that code for connective tissue components of the musculoskeletal system, may modulate susceptibility to exercise-associated muscle cramping (EAMC). The aim of mentioned study was to investigate a potential association between COL5A1 rs12722 (C/T), COL3A1 rs1800255 (G/A), COL6A1 rs35796750 (T/C), and COL12A1 rs970547 (A/G) polymorphisms and a history of EAMC.…”

“…It has a large amount of collagen fibers arranged in a hierarchal pattern giving it high tensile strength ( Tovar et al, 2010 ). Collagen is the main component of ligaments ( O’Connell et al, 2013 ) and its fibrils may be composed of collagen type I, III, VI, V, XI and XIV ( Frank et al, 2004 ). Type V collagen is a quantitatively minor fibrillar collagen, but most prominent in connective tissue where it plays an important role in regulating fiber diameter, initiating fibril assembly and regulating lateral fibril growth within tendons and ligaments ( Posthumus et al, 2011b ; Brown et al, 2011b ).…”

Less experience and running pace are potential risk factors for medical complications during a 56 km road running race: a prospective study in 26 354 race starters—SAFER study II

“…Our data are in support of the results reported in one of the earliest cross-sectional studies 16. However, older age was not shown to be a risk factor associated with EAMC in another prospective study in runners with EAMC8 or in case–control studies in endurance athletes with a history of EAMC 14 17. Therefore, the association between older age and EAMC requires further study.…”

Comparison of Gene and Protein Expressions in Rats Residing in Standard Cages with Those Having Access to an Exercise Wheel

“…The four largest DEGs occurred for the following genes: Atp2b2 (functions in intracellular calcium homeostasis), Cyp1a1 (roles in drug metabolism, synthesis of cholesterol, steroids, lipids, and NADPH-dependent electron transport pathway), Chrna1 (functions in acetylcholine binding/channel gating), and Col3a1 (roles in connective tissue and vascular function). None of these genes have previously been associated with physical activity, although Col3a1 was suspected to be associated with muscle cramping [21]. Table 3 displays fifteen unique DEGs with fold changes of at least 1.5-fold between 16 mo and 3 mo old animals in both groups.…”