Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review

Cruz, Matheus Almeida; Araújo, Tiago Akira Tashiro de; Avanzi, Ingrid Regina; Parisi, Júlia Risso; Andrade, Ana Luiza Dias Leite de; Rennó, Ana Cláudia Muniz

doi:10.1007/s10126-020-10011-6

Cited by 30 publications

(20 citation statements)

References 48 publications

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“…For instance, studies have demonstrated that collagen of different marine origin has promising effects on the process of wound repair. It is also a healthier choice to substitute mammalian with marine collagen since the former has been associated with pathological risks [ 22 , 23 ]. Even though an enormous number of by-products are generated from fisheries every year and discarded as waste, this raw material is rich in protein and, thus, can be used as a good source of bioactive compounds [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…Over the past few years, most research has focused on the isolation of compounds with potential immunomodulatory properties from natural sources, especially from the biodiverse marine ecosystem [ 21 ]. A characteristic example is marine-derived collagen, which has shown pro-healing effects on the process of cutaneous repair [ 22 , 23 ]. A large amount of sidestreams, around 70–85% of the total weight of catch, is produced by the fish processing industry every year, significantly contributing to environmental pollution [ 22 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Collagen-Containing Fish Sidestream-Derived Protein Hydrolysates Support Skin Repair via Chemokine Induction

et al. 2021

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Restoring homeostasis following tissue damage requires a dynamic and tightly orchestrated sequence of molecular and cellular events that ensure repair and healing. It is well established that nutrition directly affects skin homeostasis, while malnutrition causes impaired tissue healing. In this study, we utilized fish sidestream-derived protein hydrolysates including fish collagen as dietary supplements, and investigated their effect on the skin repair process using a murine model of cutaneous wound healing. We explored potential differences in wound closure and histological morphology between diet groups, and analyzed the expression and production of factors that participate in different stages of the repair process. Dietary supplementation with fish sidestream-derived collagen alone (Collagen), or in combination with a protein hydrolysate derived from salmon heads (HSH), resulted in accelerated healing. Chemical analysis of the tested extracts revealed that Collagen had the highest protein content and that HSH contained the great amount of zinc, known to support immune responses. Indeed, tissues from mice fed with collagen-containing supplements exhibited an increase in the expression levels of chemokines, important for the recruitment of immune cells into the damaged wound region. Moreover, expression of a potent angiogenic factor, vascular endothelial growth factor-A (VEGF-A), was elevated followed by enhanced collagen deposition. Our findings suggest that a 5%-supplemented diet with marine collagen-enriched supplements promotes tissue repair in the model of cutaneous wound healing, proposing a novel health-promoting use of fish sidestreams.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Collagen-Containing Fish Sidestream-Derived Protein Hydrolysates Support Skin Repair via Chemokine Induction

et al. 2021

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“…The main source of commercially used collagen isolation is from marine sources [ 42 ], representing an abundant and environmentally friendly reservoir of collagen [ 64 ]. The process of obtaining collagen from the transformation of by-products of fish skin and scale is inexpensive and has minimal environmental impact [ 65 ].…”

Section: Polymersmentioning

confidence: 99%

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Ribeiro,

Simões,

Vitorino

et al. 2024

Gels

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Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. This review offers a comprehensive overview and critical analysis of the key polymers that can constitute hydrogels, beginning with a brief contextualization of the polymers. It delves into their function, origin, and chemical structure, highlighting key sources of extraction and obtaining. Additionally, this review encompasses the main intrinsic properties of these polymers and their roles in the wound healing process, accompanied, whenever available, by explanations of the underlying mechanisms of action. It also addresses limitations and describes some studies on the effectiveness of isolated polymers in promoting skin regeneration and wound healing. Subsequently, we briefly discuss some application strategies of hydrogels derived from their intrinsic potential to promote the wound healing process. This can be achieved due to their role in the stimulation of angiogenesis, for example, or through the incorporation of substances like growth factors or drugs, such as antimicrobials, imparting new properties to the hydrogels. In addition to substance incorporation, the potential of hydrogels is also related to their ability to serve as a three-dimensional matrix for cell culture, whether it involves loading cells into the hydrogel or recruiting cells to the wound site, where they proliferate on the scaffold to form new tissue. The latter strategy presupposes the incorporation of biosensors into the hydrogel for real-time monitoring of wound conditions, such as temperature and pH. Future prospects are then ultimately addressed. As far as we are aware, this manuscript represents the first comprehensive approach that brings together and critically analyzes fundamental aspects of both natural and synthetic polymers constituting hydrogels in the context of cutaneous wound healing. It will serve as a foundational point for future studies, aiming to contribute to the development of an effective and environmentally friendly dressing for wounds.

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“…Waste from fish processing industries like bones and scales are revealed to have a good concentration of collagen and are also being studied as a potential source. 20,21 Detailed information about the animal and marine-derived collagen 5,20,21 is included in tables 1 and 2.…”

Section: Sources Of Collagenmentioning

confidence: 99%

Electrospun Collagen Based Nanofibrous Mats for Wound Healing: An Integrative Review

Kulkarni

Gangal

Khare

et al. 2022

Biosci., Biotech. Res. Asia

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Wound healing has always been an important issue that needs to be addressed, especially where second-and third-degree burns are considered. These types of burns extend to the dermis in second-degree burns and the tissues in third-degree burns and this process is extremely slow. Hypertrophic scarring and infection which are caused due to decreased immunity are some of the obstacles that need to be tackled. Recent studies show that fish collagen is useful in preventing infections due to its natural antimicrobial properties. Increased cellular respiration, exudate removal and retention of moisture are a few events that promote wound healing and these are aided by electrospun nanofibrous mats. Combining the properties of collagen into the nanofibrous mats in order to facilitate wound healing can potentially serve as an alternative to the current wound healing therapies. This article covers the various types of collagen that can be used with a focus on the synthetic polymeric blending into the collagen structures and its electrospinning process.

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Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review

Cited by 30 publications

References 48 publications

Collagen-Containing Fish Sidestream-Derived Protein Hydrolysates Support Skin Repair via Chemokine Induction

Collagen-Containing Fish Sidestream-Derived Protein Hydrolysates Support Skin Repair via Chemokine Induction

Hydrogels in Cutaneous Wound Healing: Insights into Characterization, Properties, Formulation and Therapeutic Potential

Electrospun Collagen Based Nanofibrous Mats for Wound Healing: An Integrative Review

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