Collagen fabricated delivery systems for wound healing: A new roadmap

Gajbhiye, Shruti; Wairkar, Sarika

doi:10.1016/j.bioadv.2022.213152

Cited by 45 publications

(27 citation statements)

References 81 publications

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“…Despite this, there were numerous other studies that employed even more complex collagen matrices than a simple coating, confirming the positive effect of this structural protein on the growth, vitality, and migration of fibroblasts [ 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 96%

Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study

Romasco

Mandrillo²,

Morsut

et al. 2023

Biomedicines

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Maintaining periodontal and peri-implant soft tissues health is crucial for the long-term health of teeth and dental implants. New biomedical strategies aimed at avoiding connective tissue alterations and related diseases (e.g., periodontitis and peri-implantitis) are constantly evolving. Among these, collagen-based medical products have proven to be safe and effective. Accordingly, the aim of the present study was to evaluate the effects of Dental SKIN BioRegulation (Guna S.p.a., Milan, Italy), a new injectable medical device composed of type I collagen of porcine origin, on primary cultures of human gingival fibroblasts (hGF). To this end, hGF were cultured on collagen-coated (COL, 100 µg/2 mL) or uncoated plates (CTRL) before evaluating cell viability (24 h, 48 h, 72 h, and 7 d), wound healing properties (3 h, 6 h, 12 h, 24 h, and 48 h), and the activation of mechanotransduction markers, such as FAK, YAP, and TAZ (48 h). The results proved a significant increase in cell viability at 48 h (p < 0.05) and wound closure at 24 h (p < 0.001) of hGF grown on COL, with an increasing trend at all time-points. Furthermore, COL significantly induced the expression of FAK and YAP/TAZ (p < 0.05), thereby promoting the activation of mechanotransduction signaling pathways. Overall, these data suggest that COL, acting as a mechanical bio-scaffold, could represent a useful treatment for gingival rejuvenation and may possibly help in the resolution of oral pathologies.

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Section: Discussionmentioning

confidence: 96%

Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study

Romasco

Mandrillo²,

Morsut

et al. 2023

Biomedicines

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“…Collagen, one of the most abundant proteins in the extracellular matrix, is an important source of elasticity and strength in the extracellular matrix and contributes to the structural and physiological integrity of tissues. This protein plays an important role in regulating the wound healing process by attracting fibroblasts and supporting the formation of new tissue in the wound bed [ 48 ].…”

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

“…Different strategies involving biopolymers, nanotools, blends, and anti-inflammatory and antimicrobial immobilized drugs have been studied in nanofibers, nanoparticles, hydrogels, films, and sponges based on collagen. They have been recently reported as efficient alternatives in the healing of wounds, infected or not [ 48 ]. For example, a bilayer membrane composed of collagen, chitosan, Aloe vera , and gelatin was tested on a full-thickness skin wound model.…”

Section: Treatments For Topical Infected Woundsmentioning

confidence: 99%

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

et al. 2023

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Despite the fact that skin has a stronger potential to regenerate than other tissues, wounds have become a serious healthcare issue. Much effort has been focused on developing efficient therapeutical approaches, especially biological ones. This paper presents a comprehensive review on the wound healing process, the classification of wounds, and the particular characteristics of each phase of the repair process. We also highlight characteristics of the normal process and those involved in impaired wound healing, specifically in the case of infected wounds. The treatments discussed here include proteins, lipids, and carbohydrates. Proteins are important actors mediating interactions between cells and between them and the extracellular matrix, which are essential interactions for the healing process. Different strategies involving biopolymers, blends, nanotools, and immobilizing systems have been studied against infected wounds. Lipids of animal, mineral, and mainly vegetable origin have been used in the development of topical biocompatible formulations, since their healing, antimicrobial, and anti-inflammatory properties are interesting for wound healing. Vegetable oils, polymeric films, lipid nanoparticles, and lipid-based drug delivery systems have been reported as promising approaches in managing skin wounds. Carbohydrate-based formulations as blends, hydrogels, and nanocomposites, have also been reported as promising healing, antimicrobial, and modulatory agents for wound management.

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“…Collagen has great potential in various industrial sectors such as medical, pharmaceutical, nutraceutical, and cosmetic. It has been approved for use in tissue engineering due to its ability to stimulate cellular migration, tissue matrix interaction, and tissue regeneration [ 5 , 6 ]. It is also applicable in developing drug-delivery systems and in treating hypertension, obesity, and diabetes [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Microstructural Characteristics of Collagen Biopolymer from Unicornfish (Naso reticulatus Randall, 2001) Bone Prepared with Various Acid Types

et al. 2023

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Biopolymer-like collagen has great industrial potential in terms of its excellent properties, such as strong biocompatibility, high degradability, and low antigenicity. Collagen derived from fish by-products is preferable as it is safer (free from transmittable diseases) and acceptable to most religious beliefs. This study aimed to characterize the unicornfish (Naso reticulatus Randall, 2001) bone collagens prepared with different type of acids, i.e., acetic acid, lactic acid, and citric acid. A higher yield (Y) (p < 0.05) was obtained in the citric-acid-soluble collagen (CASC) (Y = 1.36%), followed by the lactic-acid-soluble collagen (LASC) (Y = 1.08%) and acetic-acid-soluble collagen (AASC) (Y = 0.40%). All extracted collagens were classified as type I due to the presence of 2-alpha chains (α1 and α2). Their prominent absorption spectra were located at the wavelengths of 229.83 nm to 231.17 nm. This is similar to wavelengths reported for other fish collagens. The X-ray diffraction (XRD) and infrared (IR) data demonstrated that the triple-helical structure of type I collagens was still preserved after the acid-extraction process. In terms of thermal stability, all samples had similar maximum transition temperatures (Tmax = 33.34–33.51 °C). A higher relative solubility (RS) of the unicornfish bone collagens was observed at low salt concentration (0–10 g/L) (RS > 80%) and at acidic condition (pH 1.0 to pH 3.0) (RS > 75%). The extracted collagen samples had an irregular and dense flake structure with random coiled filaments. Overall, bones of unicornfish may be used as a substitute source of collagen.

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Collagen fabricated delivery systems for wound healing: A new roadmap

Cited by 45 publications

References 81 publications

Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study

Morpho-Functional Effect of a New Collagen-Based Medical Device on Human Gingival Fibroblasts: An In Vitro Study

The Use of Proteins, Lipids, and Carbohydrates in the Management of Wounds

Biochemical and Microstructural Characteristics of Collagen Biopolymer from Unicornfish (Naso reticulatus Randall, 2001) Bone Prepared with Various Acid Types

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