Collagen, elastin and glycosaminoglycans in aortic aneurysms.

Sobolewski, Krzysztof; Wolańska, Małgorzata; Bańkowski, Edward; Gacko, Marek; Głowiński, S

doi:10.18388/abp.1995_4588

Cited by 18 publications

(12 citation statements)

References 20 publications

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“…Keratan sulfate (KS) is a complex glycosaminoglycan (GAG) with several structurally and functionally diverse proteoglycan forms including fibromodulin, which is associated with collagen production and inflammatory cytokines[40]. More generally, it has been shown that that total amount of GAGs is lower in aortic aneurysms compared to normal aortas[41]. It is therefore plausible that this represents another mechanism of aneurysm formation/rupture, thus corroborating our finding outlined above.…”

Section: Discussionsupporting

confidence: 76%

Microenvironment of ruptured cerebral aneurysms discovered using data driven analysis of gene expression

et al. 2019

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Background It is well known that ruptured intracranial aneurysms are associated with substantial morbidity and mortality, yet our understanding of the genetic mechanisms of rupture remains poor. We hypothesize that applying novel techniques to the genetic analysis of aneurysmal tissue will yield key rupture-associated mechanisms and novel drug candidates for the prevention of rupture. Methods We applied weighted gene co-expression networks (WGCNA) and population-specific gene expression analysis (PSEA) to transcriptomic data from 33 ruptured and unruptured aneurysm domes. Mechanisms were annotated using Gene Ontology, and gene network/population-specific expression levels correlated with rupture state. We then used computational drug repurposing to identify plausible drug candidates for the prevention of aneurysm rupture. Results Network analysis of bulk tissue identified multiple immune mechanisms to be associated with aneurysm rupture. Targeting these processes with computational drug repurposing revealed multiple candidates for preventing rupture including Btk inhibitors and modulators of hypoxia inducible factor. In the macrophage-specific analysis, we identify rupture-associated mechanisms MHCII antigen processing, cholesterol efflux, and keratan sulfate catabolism. These processes map well onto several of highly ranked drug candidates, providing further validation. Conclusions Our results are the first to demonstrate population-specific expression levels and intracranial aneurysm rupture, and propose novel drug candidates based on network-based transcriptomics.

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Section: Discussionsupporting

confidence: 76%

Microenvironment of ruptured cerebral aneurysms discovered using data driven analysis of gene expression

et al. 2019

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“…Rizzo found a similar substantial increase in collagen (hydroxyproline analysis) and decrease in elastin (hot alkali extraction) to only 1% in AAA aortic walls, reducing the ELN/ COL ratio from 0.5 (n = 13) to 0.03 (n = 19; Rizzo et al, 1989). Similarly, multiple other studies identified a trend of decreasing ELN/COL ratio and significantly fewer ELN crosslinks in AAA patients, as the ELN/COL ratio decreased in nonruptured AAA from 0.63 (n = 7) to 0.2 (n = 13; Sobolewski et al, 1995) and 0.84 (n = 24) to 0.13 (n = 26;Carmo et al, 2002).…”

Section: Aortic Aneurysmsmentioning

confidence: 82%

Extracellular Matrix Protein Ratios in the Human Heart and Vessels: How to Distinguish Pathological From Physiological Changes?

Wittig

Szulcek

2021

Front. Physiol.

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Cardiovascular pathology is often accompanied by changes in relative content and/or ratios of structural extracellular matrix (ECM) proteins within the heart and elastic vessels. Three of these proteins, collagen-I, collagen-III, and elastin, make up the bulk of the ECM proteins in these tissues, forming a microenvironment that strongly dictates the tissue biomechanical properties and effectiveness of cardiac and vascular function. In this review, we aim to elucidate how the ratios of collagen-I to collagen-III and elastin to collagen are altered in cardiovascular diseases and the aged individuum. We elaborate on these major cardiovascular ECM proteins in terms of structure, tissue localization, turnover, and physiological function and address how their ratios change in aging, dilated cardiomyopathy, coronary artery disease with myocardial infarction, atrial fibrillation, aortic aneurysms, atherosclerosis, and hypertension. To the end of guiding in vitro modeling approaches, we focus our review on the human heart and aorta, discuss limitations in ECM protein quantification methodology, examine comparability between studies, and highlight potential in vitro applications. In summary, we found collagen-I relative concentration to increase or stay the same in cardiovascular disease, resulting in a tendency for increased collagen-I/collagen-III and decreased elastin/collagen ratios. These ratios were found to fall on a continuous scale with ranges defining distinct pathological states as well as a significant difference between the human heart and aortic ECM protein ratios.

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“…To address those limitations, modifications of collagen and gelatin based systems by the combination with other proteins, such as glycosaminoglycan, fibrin, and biotin, were proposed. The role of glycosaminoglycan and difference in its concentrations between pathological and normal tissues were reported earlier [33]. Dermal skin substitutes (membranes) made of collagen and glycosaminoglycan were found to be suitable substrates for the culture of human epidermal keratinocytes [27].…”

Section: A Collagen and Gelatin As Implantsmentioning

confidence: 82%

Biomedical and Pharmaceutical Application of Fish Collagen and Gelatin: A Review

Wu¹

2013

J. Nutr. Ther.

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In last decade, more research has been conducted in order to find the better way for utilizing the wastes product generated from food processing industries. The increasing demand of industrial by-products is one of the main reasons for the conversion of these wastes into valuable products. Among the different valuable products from the waste, the extraction of collagen and gelatin could be a better way of utilizing the wastes, due to their effective applications in biomedical and pharmaceutical industries. The most abundant source of collagen and gelatin are landbased animals, such as cow and pig. However, the extraction of collagen and gelatin from non-mammalian sources such as fish has been high influences in current society due to some religious and disease transmission issues. Many studies have dealt with the extraction and functional properties of collagen and gelatin from fish wastes. The present work is a compilation of information on biomedical and pharmaceutical application of collagen and gelatin from fish processing wastes.

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Collagen, elastin and glycosaminoglycans in aortic aneurysms.

Cited by 18 publications

References 20 publications

Microenvironment of ruptured cerebral aneurysms discovered using data driven analysis of gene expression

Microenvironment of ruptured cerebral aneurysms discovered using data driven analysis of gene expression

Extracellular Matrix Protein Ratios in the Human Heart and Vessels: How to Distinguish Pathological From Physiological Changes?

Biomedical and Pharmaceutical Application of Fish Collagen and Gelatin: A Review

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