Collagen deposition correlates with loss of E-cadherin and increased p63 expression in dysplastic conditions of oral submucous fibrosis

The interplay of EMT and stemness driving malignant transformation of Oral Submucous Fibrosis

“…About 20 % of the OSF cases exhibited loss of E-cadherin expression in the basal layer. Hosur et al, 21 and Chakraborti et al, 22 also reported loss of E-cadherin expression in the basal layer in OSF, indicating impaired intercellular junctions and initiation of the carcinogenic process in the basal epithelial layer. Additionally, excessive collagen deposition in OSF can result in decline of E-cadherin integrity.…”

“…Additionally, excessive collagen deposition in OSF can result in decline of E-cadherin integrity. 22 The loss of E-cadherin in OSCC was documented by López-Verdín et al, 23 and Hakim et al, 24 proving the acquisition of invasive behavior with the repression of E-cadherin. 25 One possible explanation for the suppression of E-cadherin in OSF and OSCC is the transcription factor SNAIL, which is upregulated by TGFβ and IL-6 via the TGFβ-R/SMAD2/SMAD3/SMAD4 and JAK/STAT-3 pathways, respectively.…”

Early Histopathology In Oral Submucous Fibrosis (OSF) To Rule The Possibility Of Epithelial Dysplasia - Report Of Two Cases

“…There are studies on expression of neo-angiogenic markers like VEGF and CD105 in Oral Submucous Fibrosis which depicts the progression of Oral Submucous Fibrosis from non-dysplasia to dysplasia 15 . This occurs due to loss of e-cadherin along with the upregulation of expression in the cytoplasm rather than membrane, leading to the dysplastic progression 16 .…”

Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review

“…These characteristics, linked to changes in epithelial architecture and molecular processes during different stages of precancerous development and its progression into malignancy, can be better identified with the assistance of graph-theoretic features that describe the spatial arrangement of p63+ nuclei with specific histopathological associations. Average roundness factor (ARF), mean tessellation area (MTA), mean tessellation perimeter (MTP), and tessellation disorder of area (TDA) serve to illustrate the diverse conditions of the nucleus in both normal and diseased samples [58]. Quantifying the p63 intensity across the entire oral epithelium using mean grey values for red is feasible.…”