Abstract:Collagen cross-linking enhances the mechanical properties of bone by improving toughness of the bone matrix. Randomized electrical stimulation contributes positively to the behavior of osteoblastic cell in vitro by promoting osteogenic differentiation and mineral deposition. However, the effects of randomized electrical stimulation on collagen crosslink formation, which are associated with bone toughness, are yet to be elucidated. In this study, we identify the effects of randomized electrical stimulation on c… Show more
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