Collagen content as a risk factor in breast cancer? A pilot clinical study.

Pifferi, Antonio; Quarto, Giovanna; Abbate, Francesca; Balestreri, Nicola; Menna, Simona; Cassano, Enrico; Cubeddu, Rinaldo; Taroni, Paola

doi:10.1364/ecbo.2015.953813

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…This is because collagen quanti cation can be less accurate, due to the overall weak absorption of collagen and to the overlap of its absorption line shape with that of the strongly absorbing deoxyhemoglobin at short wavelengths and with that of lipids and water at long wavelength 31 . However, information on collagen content is of great interest since it is directly involved in the development of breast cancer and is itself a potential risk factor [40][41][42] Previous in vivo and ex vivo studies 32 have found that the scattering power b correlates with collagen and this is con rmed by our results (r = 0.844, p = 0.001). Thus, the Collagen Index (CI), that combines collagen concentration with the scattering power b, enhancing their correlation, could amplify their informative content.…”

Section: Estimate Of Breastsupporting

confidence: 77%

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.

Serra,

Cubeddu,

Maffeis

et al. 2024

Preprint

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In this study, time domain diffuse optical spectroscopy is performed in the range 600–1100 nm on 11 healthy volunteers with a portable system for the quantitative characterization of breast tissue in terms of optical properties and optically-derived blood parameters, tissue constituent concentrations, and scattering parameters. A measurement protocol involving different geometries (reflectance and transmittance), subject’s positions (sitting and lying down), probing locations (outer, lower, and inner breast quadrants), and source-detector distances (2 and 3 cm) allowed us to investigate the effect of tissue heterogeneity and different measurement configurations on the results with the aim of identifying the best experimental conditions for the estimate of breast density (i.e., amount of fibro-glandular tissue in the breast) as a strong independent risk factor for breast cancer. The higher source-detector distance, which probes deeper tissue, retrieves optical outcomes in agreement with higher average density tissue. Similarly, results on the outer quadrants indicate higher density than internal quadrants. These findings are coherent with breast anatomy since the concentration of dense fibro-glandular stroma is higher in deep tissue and towards the external portion of the breast, where the mammary gland is located. The dataset generated with this laboratory campaign is used to device an optimal measurement protocol for a future clinical trial, where optical results will be correlated with conventional mammographic density, allowing us to identify a subset of wavelengths and measurement configurations for an effective estimate of breast density. The final objective is the design of a simplified, compact and cost-effective optical device for a non-invasive, routine assessment of density-associated breast cancer risk.

show abstract

Section: Estimate Of Breastsupporting

confidence: 77%

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.

Serra,

Cubeddu,

Maffeis

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density

Serra,

Cubeddu,

Maffeis

et al. 2024

Sci Rep

View full text Add to dashboard Cite

In this study, time domain diffuse optical spectroscopy is performed in the range 600–1100 nm on 11 healthy volunteers with a portable system for the quantitative characterization of breast tissue in terms of optical properties and optically-derived blood parameters, tissue constituent concentrations, and scattering parameters. A measurement protocol involving different geometries (reflectance and transmittance), subject’s positions (sitting and lying down), probing locations (outer, lower, and inner breast quadrants), and source-detector distances (2 and 3 cm) allowed us to investigate the effect of tissue heterogeneity and different measurement configurations on the results with the aim of identifying the best experimental conditions for the estimate of breast density (i.e., amount of fibro-glandular tissue in the breast) as a strong independent risk factor for breast cancer. Transmittance results, that in previous studies correlated strongly with mammographic density, are used as a reference for the initial test of the simpler and more comfortable reflectance measurement configuration. The higher source-detector distance, which probes deeper tissue, retrieves optical outcomes in agreement with higher average density tissue. Similarly, results on the outer quadrants indicate higher density than internal quadrants. These findings are coherent with breast anatomy since the concentration of dense fibro-glandular stroma is higher in deep tissue and towards the external portion of the breast, where the mammary gland is located. The dataset generated with this laboratory campaign is used to device an optimal measurement protocol for a future clinical trial, where optical results will be correlated with conventional mammographic density, allowing us to identify a subset of wavelengths and measurement configurations for an effective estimate of breast density. The final objective is the design of a simplified, compact and cost-effective optical device for a non-invasive, routine assessment of density-associated breast cancer risk.

show abstract

Collagen content as a risk factor in breast cancer? A pilot clinical study.

Cited by 2 publications

References 11 publications

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.

In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density

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