Collagen-chitosan scaffold - Lauric acid plasticizer for skin tissue engineering on burn cases

Widiyanti, Prihartini; Setyadi, Ewing Dian; Rudyardjo, Djony Izak

doi:10.1063/1.4976765

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Furthermore, the ultimate strength and Young's modulus in this study were in the standard range of skin tissue. Each is 1-24 MPa [33], and Young's modulus range is 5-140 MPa [34], so these results can be the basis for further studies in the application of collagen-chitosan/PVA nanofiber composites for skin tissue engineering.…”

Section: Mechanical Propertiesmentioning

confidence: 82%

Mechanical, degradation rate, and antibacterial properties of a collagen-chitosan/PVA composite nanofiber

Hartatiek

Fathurochman

Wuriantika

et al. 2023

Mater. Res. Express

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This study synthesized collagen-chitosan/PVA nanofiber composites using the electrospinning method. Characterizations included Fourier transform infrared spectroscopy (FTIR) and surface morphology using scanning electron microscopy (SEM). Investigations were carried out on tensile strength, degradation rate, and antibacterial test. It was found that the functional groups C–H, –OH, C–O, C–N, and N–H were suitable for PVA, collagen, and chitosan materials. The SEM showed that increasing the PVA composition caused a change in fiber diameter ranging from 34.64 to 71.63 nm. The tensile strength results show that the smallest nanofiber diameter has the highest ultimate strength value of 5.6 ± 0.4 MPa. In addition, it was found that the rate of degradation was in the range of 44%–76%. The antibacterial activity test was carried out using two types of bacteria, i.e., a gram-positive bacteria, S. aureus, and a gram-negative bacteria, E. coli. The test results showed that the collagen-chitosan/PVA nanofiber composite had a diameter of antibacterial inhibition for E. coli and S. aureus bacteria, respectively.

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Section: Mechanical Propertiesmentioning

confidence: 82%