Collagen Biografts for Tunable Drug Delivery

Joshi, Rucha

doi:10.1007/978-3-030-63817-7

Cited by 5 publications

(4 citation statements)

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“…if enzymatically digested, degraded or dissolved) [317]. Moreover, collagen, as a fibrillary matrix, makes an excellent material with low immunogenicity, since it can degrade into physiologically well-tolerated products [320]. As a natural polymer, it provides advantages related to its inherent cell-signalling potential.…”

Section: Collagenmentioning

confidence: 99%

“…The currently known methods to change local kinetics in on-site drug delivery using collagen-based matrices include cross-linking the matrix [321], changing the doping agent to make the drug less soluble [221], using a diffusion restrictor or a diffusion barrier [322], and composite with other materials [323][324][325], as shown in Figure 9. Nevertheless, some limitations are also reported, for example, exogenous crosslinking has shown to induce detrimental effects on cells and tissues, such as cytotoxicity, tissue calcification or even partial denaturation of collagen itself [320]. It is generally accepted that the control over defined molecular composition, mechanical integrity and drug release profiles is required in order to promote their clinical translation.…”

Section: Collagenmentioning

confidence: 99%

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Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem

Kamarudin

Bhaskar

et al. 2023

International Materials Reviews

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Peri-implant infection is rapidly becoming anif not the mostimportant clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies.

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Section: Collagenmentioning

confidence: 99%

Section: Collagenmentioning

confidence: 99%

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem

Kamarudin

Bhaskar

et al. 2023

International Materials Reviews

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“…It is primarily found in the skin, bone, tendon, and connective tissue organs of human and animal bodies. There are 29 collagen types identified based on structure and presence in specific tissues [25], and they have been broadly classified as fibrillar and non-fibrillar types. Fibrillar collagens are commonly found in human bodies and can be subdivided into Type I (found in skin, tendons, vasculature, organs, and bones); Type II (found in cartilage); Type III (found in reticulate); Type IV (found in basal lamina); and Type V (found in cell surfaces, hair, and placenta) [26].…”

Section: Structurementioning

confidence: 99%

Rheological and viscoelastic properties of collagens and their role in bioprinting by micro-extrusion

Lan¹,

Adesida²,

Boluk³

2022

Biomed. Mater.

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This article aims to understand the rheology of collagen networks and their role in various stages of a bioprinting process while building tissue-like constructs. The science of rheology, which deals with the deformation and flow of matter, has grown considerably from its earlier focus on polymer melts and solutions and their processing methods to hydrogels with new processing procedures, such as bioprinting. The main objective of this paper is to discuss the impact of the rheology of collagen hydrogels on micro-extrusio and layer stacking stages of bioprinting. Generally, the rheological characterization of hydrogels, including collagens by dynamic measurements under small deformations, is considered sufficient to evaluate their bioprinting performance. However, we brought out the importance of other rheological properties of collagen networks such as steady-state shear flow conditions and large amplitude oscillator shear. While the dynamic measurements under small deformations are useful for characterizing the crosslinking and gel formations of the collagen, the steady shear flow measurements are better tools for investigating filament micro-extrusion and layer-stacking stages of a bioprinting process. We brought the role of other non-Newtonian material functions, such as first normal stress difference and extensional viscosity in addition to shear viscosity, for the first time. Extensional viscosity and the viscoelasticity manifested through normal-stress differences are significant in capillary (needle) flow. We also suggested caution to use of dynamic viscosity vs. oscillation frequency under small deformations in the place of steady shear viscosity vs. shear rate measurement. In addition, we brought out the importance of the large amplitude oscillatory shear test to investigate the collagen networks under large deformations. Finally, we discussed the role of crosslinking and flow conditions on cell viability. Those discussions are focused on collagen networks; nevertheless, they are valid on the bioprinting of other hydrogels.

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“…The structural and signaling role of collagen makes it an ideal biomaterial for applications in the field of biomedical [7], cosmetics [8], nutraceuticals [9] and pharmaceuticals. In addition, natural properties like hemostatic activity [10], biodegradability [11] and cross-linking ability of collagen find a wide application in the drug delivery systems [12][13][14]. Gelatin, a biopolymer obtained by partial hydrolysis of collagen fibres has major applications in confectionery, food, pharmaceutical, medical, cosmetic products [15].…”

Section: Introductionmentioning

confidence: 99%

A Guide to Collagen Sources, Applications and Current Advancements

Bhadra

Sakpal

Patil

et al. 2021

Systematic Bioscience and Engineering

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The increase in use of collagen products in almost every sector of utility has stipulated the rising demand for collagen. It is an essential fibrous glycoprotein, which is abundantly present in the extracellular matrix and connective tissues in many living organisms. Owing to its unique characteristics such as biocompatibility, bioavailability and weak antigenicity it has gained major interest in the food, pharmaceutical, cosmetic, biomedical and leather industries. The collagen-based composites possess an enhanced capacity to dissipate mechanical energy, strength and stiffness making it the most promising biomolecule for its multifaceted applications. Recently, synthetic biology platforms are getting wide attention for the production of non-native collagen alternatives to meet the rising demand for collagen worldwide. In the initial part, this review aims to explain different sources, structures, biosynthesis of collagen and its types followed by the emerging applications of collagen as a next-generation biomaterial in the later part. The article emphasises the synthesis of non-native collagen using novel expression systems like plant and algae in addition to bacteria and yeast with industrial consideration. In the conclusion section, challenges and opportunities of using synthetic biology tools are described.

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Collagen Biografts for Tunable Drug Delivery

Cited by 5 publications

References 0 publications

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Rheological and viscoelastic properties of collagens and their role in bioprinting by micro-extrusion

A Guide to Collagen Sources, Applications and Current Advancements

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