Collagen‐binding proteins of <i>Streptococcus mutans</i> and related streptococci

Avilés‐Reyes, Alejandro; Miller, James H.; Lemos, José A.; Abranches, Jacqueline

doi:10.1111/omi.12158

Cited by 56 publications

(60 citation statements)

References 159 publications

(277 reference statements)

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“…S. mutans also harbors collagen-binding Cnm and Cbm adhesins in 15% and 3% of clinical isolates, respectively, and more frequently in serotype e , f and k than in c isolates ( Avilés-Reyes et al, 2017 ). Cnm/Cbm are highly homologous and consist, similar to collagen-binding proteins in Staphylococcus aureus and other bacteria ( Kang et al, 2013 ; Xu et al, 2004 ), of an N-terminal collagen-binding domain presented on a stalk formed by several threonine-rich repeat domains and a cell wall anchoring region ( Nomura et al, 2009 , 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development

et al. 2017

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Dental caries, which affects billions of people, is a chronic infectious disease that involves Streptococcus mutans, which is nevertheless a poor predictor of individual caries development. We therefore investigated if adhesin types of S.mutans with sucrose-independent adhesion to host DMBT1 (i.e. SpaP A, B or C) and collagen (i.e. Cnm, Cbm) match and predict individual differences in caries development. The adhesin types were measured in whole saliva by qPCR in 452 12-year-old Swedish children and related to caries at baseline and prospectively at a 5-year follow-up. Strains isolated from the children were explored for genetic and phenotypic properties. The presence of SpaP B and Cnm subtypes coincided with increased 5-year caries increment, and their binding to DMBT1 and saliva correlated with individual caries scores. The SpaP B subtypes are enriched in amino acid substitutions that coincided with caries and binding and specify biotypes of S. mutans with increased acid tolerance. The findings reveal adhesin subtypes of S. mutans that match and predict individual differences in caries development and provide a rationale for individualized oral care.

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Section: Introductionmentioning

confidence: 99%

Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development

et al. 2017

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“…mutans belongs to a group of bacteria whose pathogenicity is closely related to their capacity of creating biofilms on solid surfaces (such as teeth), developing 3D structures that protect them against antibiotics and other potential aggressors through the interbacterial interactions and an exopolysaccharide-rich matrix [12,13]. This species synthesizes several adhesins with high affinity and specificity for a diversity of constituents of the extracellular matrix (ECM) and other biochemical compounds from the human body or from different species of bacteria [14]. An adhesin protein, located on the cell surface of S. mutans and known as spaP, AgI/II, PAc, P1, B, and MSL-1, interacts with a human receptor glycoprotein involved in innate immunity, and when this receptor protein becomes adsorbed upon the surface of the teeth, it will also function as a receptor for the adherence of streptococci such as S. mutans [15].…”

Section: Introductionmentioning

confidence: 99%

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

et al. 2019

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It is currently recognized that an injudicious strategy about caries in the last decades has been not only focusing of research mostly in children, but also the narrow focusing on fluoride, because despite sufficient availability of fluoride in water and oral healthcare products, caries levels escalate steadily as people get older and caries remain a main public health issue to be settled. In the last two decades the scientific community intensified efforts of exploring other products for caries prevention, herbal products being one of these approaches. Preliminary evidence indicated that clinical trials for caries prevention with herbal products are heterogeneous in design, quality and products evaluated, we therefore performed a scoping review intended to explore the main characteristics of such clinical trials. From an initial collection of 1986 unique papers from different literature databases, 56 articles satisfied the inclusion and exclusion criteria. The species investigated, dosage forms, study designs, duration of intervention, controls, endpoints, quality of reporting, and risk of bias are discussed. Of the trials reviewed here, 85.71% reported positive results but given the methodological flaws and biases affecting them, it is difficult to conclude on the efficacy of those products based on the studies published thus far.

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“…mutans belongs to a group of bacteria whose pathogenicity is closely related to their capacity of creating biofilms on solid surfaces (such as teeth), developing 3D structures that protect them against antibiotics and other potential aggressors through the interbacterial interactions and an exopolysaccharide-rich matrix [12,13]. This species synthesizes several adhesins with high affinity and specificity for a diversity of constituents of the extracellular matrix (ECM) and other biochemical compounds from the human body or from different species of bacteria [14]. An adhesin protein, located on the cell surface of S. mutans and known as spaP, AgI/II, PAc, P1, B and MSL-1, interacts with a human receptor glycoprotein involved in innate immunity, and when this receptor protein becomes adsorbed upon the surface of the teeth, it will also function as a receptor for the adherence of streptococci such as S. mutans [15].…”

Section: Introductionmentioning

confidence: 99%

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

Ancuceanu¹,

Anghel²,

Ionescu³

et al. 2019

Preprint

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It is currently recognized that an injudicious strategy in the last decades has been not only focusing of research typically on caries in children, but also the narrow focusing on fluoride, because despite sufficient availability of fluoride in water and oral healthcare products, caries levels escalate steadily as people get older and caries remain a main public health issue to be settled. In the last two decades the scientific community intensified efforts of exploring other products for caries prevention, herbal products being one of these approaches. Because preliminary evidence indicated that clinical trials for caries prevention with herbal products are heterogeneous in design, quality and products evaluated, we performed a scoping review intended to explore the main characteristics of such clinical trials. From an initial collection of 1986 unique papers from different literature databases, 56 articles satisfied the inclusion and exclusion criteria. The species investigated, dosage forms, study designs, duration of intervention, controls, endpoints, quality of reporting and risk of bias are discussed. 85.71% of the trials reviewed here reported positive results but given the methodological flaws and biases affecting them, it is difficult to conclude on the efficacy of those products based on the studies published thus far.

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Collagen‐binding proteins of Streptococcus mutans and related streptococci

Cited by 56 publications

References 159 publications

Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development

Streptococcus Mutans Adhesin Biotypes that Match and Predict Individual Caries Development

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study

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