Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes

Roată, Cristian Ene; Iacob, Ștefan; Morărașu, Ștefan; Livadaru, Cristian; Tudorancea, Ionuț; Luncă, Sorinel; Dimofte, Mihail‐Gabriel

doi:10.3390/cryst11111396

Cited by 6 publications

(5 citation statements)

References 36 publications

(82 reference statements)

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“…As previously described [14][15][16], a systematic search of the PubMed database was performed for all published studies relating to in vivo models of anti-tumor drug delivery via pH-responsive NPs using the following search algorithm: pH AND nanoparticles AND cancer AND delivery AND in vivo. The systematic search was carried out by adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines which were adapted to experimental studies [17].…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

Morărașu

Morăraşu

Ghiarasim³

et al. 2022

Gels

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(1) Background: In recent years, several studies have described various and heterogenous methods to sensitize nanoparticles (NPs) to pH changes; therefore, in this current scoping review, we aimed to map current protocols for pH functionalization of NPs and analyze the outcomes of drug-loaded pH-functionalized NPs (pH-NPs) when delivered in vivo in tumoral tissue. (2) Methods: A systematic search of the PubMed database was performed for all published studies relating to in vivo models of anti-tumor drug delivery via pH-responsive NPs. Data on the type of NPs, the pH sensitization method, the in vivo model, the tumor cell line, the type and name of drug for targeted therapy, the type of in vivo imaging, and the method of delivery and outcomes were extracted in a separate database. (3) Results: One hundred and twenty eligible manuscripts were included. Interestingly, 45.8% of studies (n = 55) used polymers to construct nanoparticles, while others used other types, i.e., mesoporous silica (n = 15), metal (n = 8), lipids (n = 12), etc. The mean acidic pH value used in the current literature is 5.7. When exposed to in vitro acidic environment, without exception, pH-NPs released drugs inversely proportional to the pH value. pH-NPs showed an increase in tumor regression compared to controls, suggesting better targeted drug release. (4) Conclusions: pH-NPs were shown to improve drug delivery and enhance antitumoral effects in various experimental malignant cell lines.

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Section: Literature Search and Study Selectionmentioning

confidence: 99%

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

Morărașu

Morăraşu

Ghiarasim³

et al. 2022

Gels

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“…pNIPAM is a thermoresponsive polymer that has been extensively studied for use in drug delivery systems, in part because it undergoes phase transition around 33 °C (LCST, lower critical solution temperature). − At physiological temperatures, pNIPAM undergoes hydrophobic collapse, allowing a sustained release of encapsulated compounds while providing protection from physicochemical degradation. Additionally, pNIPAM can be co-polymerized with co-monomers containing functional groups that allow chemical modification with targeting ligands. , To increase nanoparticle functionality, the pNIPAM shell surface was modified with collagen type I-binding peptide (RRANAALKAGELYKSILYGC, abbreviated SILY). − Collagen targeting can be justified by the fact that the mammary extracellular matrix undergoes changes during the process of carcinogenesis that include the overexpression of type I collagen. − Thus, collagen can potentially be a better target in breast cancer therapy than surface markers and receptors of the neoplastic cells, which may vary according to the tumor type, leading to prolonged retention at the site of action after intraductal administration and increased selectivity to tumor cells.…”

Section: Introductionmentioning

confidence: 99%

“… 23 − 25 Collagen targeting can be justified by the fact that the mammary extracellular matrix undergoes changes during the process of carcinogenesis that include the overexpression of type I collagen. 26 − 29 Thus, collagen can potentially be a better target in breast cancer therapy than surface markers and receptors of the neoplastic cells, which may vary according to the tumor type, 28 leading to prolonged retention at the site of action after intraductal administration and increased selectivity to tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Collagen-Binding Nanoparticles for Paclitaxel Encapsulation and Breast Cancer Treatment

Passos,

Lopes,

Panitch

2023

ACS Biomater. Sci. Eng.

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In this study, we developed a novel hybrid collagen-binding nanocarrier for potential intraductal administration and local breast cancer treatment. The particles were formed by the encapsulation of nanostructured lipid carriers (NLCs) containing the cytotoxic drug paclitaxel within a shell of poly( N -isopropylacrylamide) (pNIPAM), and were functionalized with SILY, a peptide that binds to collagen type I (which is overexpressed in the mammary tumor microenvironment) to improve local retention and selectivity. The encapsulation of the NLCs in the pNIPAM shell increased nanoparticle size by approximately 140 nm, and after purification, a homogeneous system of hybrid nanoparticles (∼96%) was obtained. The nanoparticles exhibited high loading efficiency (<76%) and were capable of prolonging paclitaxel release for up to 120 h. SILY-modified nanoparticles showed the ability to bind to collagen-coated surfaces and naturally elaborated collagen. Hybrid nanoparticles presented cytotoxicity up to 3.7-fold higher than pNIPAM-only nanoparticles on mammary tumor cells cultured in monolayers. In spheroids, the increase in cytotoxicity was up to 1.8-fold. Compared to lipid nanoparticles, the hybrid nanoparticle modified with SILY increased the viability of nontumor breast cells by up to 1.59-fold in a coculture model, suggesting the effectiveness and safety of the system.

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“…It accounts for more than 30% of all body proteins. Due to numerous advantages such as biocompatibility, biodegradability, non-immunogenicity, non-toxicity, tensile strength, low antigenicity, extensibility, and accessibility, it plays an essential role in the synthesis of nanoparticles in various biomedical fields, especially in drug delivery and tissue engineering [ 136 , 137 , 138 ]. Biodegradable and thermally stable collagen nanoparticles are suitable nanocarriers for many therapeutic and cytotoxic substances, genes, proteins, growth factors, and drugs.…”

Section: Animal-based Biopolymeric Nanoparticles Used For Healthcare ...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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Collagen-Binding Nanoparticles: A Scoping Review of Methods and Outcomes

Cited by 6 publications

References 36 publications

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

Collagen-Binding Nanoparticles for Paclitaxel Encapsulation and Breast Cancer Treatment

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

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