Collagen‐Based Porous Scaffolds for Tissue Engineering

Chen, Guoping; Naoki, Katsuhiko

doi:10.1002/9781119126218.ch1

Cited by 4 publications

(5 citation statements)

References 45 publications

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“…Desired scaffolds in TE are providing a porous structure, in which the porosity ≥70% as well as interconnected pores allowing cell growth is ideal. 16 In this work, four scaffold types including two Col blended have been prepared, in the form of 3D.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Three-Dimensional Scaffolds Based on Nano-biomimetic Collagen Hybrid Constructs for Skin Tissue Engineering

et al. 2018

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Three-dimensional (3D) biodegradable and biomimetic porous scaffolds are ideal frameworks for skin tissue engineering. In this study, hybrid constructs of 3D scaffolds were successfully fabricated by the freeze-drying method from combinations of the type I collagen (Col) and synthetic poly(lactic acid) (PLLA) or polycaprolactone (PCL). Four different groups of 3D porous scaffolds including PCL, PCL–Col, PCL–PLLA, and PCL–PLLA–Col were fabricated and systematically characterized by hydrogen nuclear magnetic resonance, Fourier transform infrared spectroscopy, and scanning electron microscopy (SEM). Adipose tissue-derived mesenchymal stem cells (AT-MSCs) were seeded in all scaffolds, and the viability, proliferation, and adhesion of the cells were investigated using dimethylthiazol diphenyltetrazolium bromide assay and SEM. The results showed that scaffolds containing Col, particularly PCL–PLLA–Col scaffold, with pore sizes close to 400 nm and being sufficiently interconnected, have significantly greater potential ( p < 0.01) for encouraging AT-MSCs adhesion and growth. The PCL–PLLA provided a mechanically stronger mesh support, and the type I Col microsponges encouraged excellent cell adhesion and tissue formation. The scaffold with the best properties could be an appropriate functional candidate for the preparation of artificial skin constructs.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Three-Dimensional Scaffolds Based on Nano-biomimetic Collagen Hybrid Constructs for Skin Tissue Engineering

et al. 2018

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“…The results were obtained by histological and micro-computed tomography, uncovering a substantial degree of cellular infiltration during the early healing phase and eventually higher bone density 8 weeks from the grafting procedure. (41) In addition, collagen plugs possess a porous structure that enables them to absorb fluid and blood at the extraction site, thus enhancing their hemostatic properties, which help control bleeding (12).…”

Section: Discussionmentioning

confidence: 99%

“…All these studies have revealed positive results. (12)(13)(14)(15) Collagen is a class of nearly 29 polymeric proteins that make up the most prevalent extracellular matrix (ECM) protein component and account for around one-third of the weight of protein content in mammals (16). Three procollagen polypeptide chains produce a distinctive triple helix in all collagen proteins.…”

Section: Introductionmentioning

confidence: 99%

Biological effect of collagen scaffolds on rabbit’s socket healing

Hafez,

Koura,

Kawana

et al. 2023

Alexandria Dental Journal

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BACKGROUND:Tooth extraction initiates a series of biological processes, including alveolar bone resorption driven by the inflammatory response; this eventually leads to alveolar bone resorption. Many researchers have focused on controlling this phenomenon and accelerating new bone formation following tooth extraction. Grafting biomaterials in the extraction socket is now the most dependable and successful strategy for reducing post-extraction resorption. Collagen plugs in the sockets might be an option with potentially desirable outcomes. OBJECTIVES: To assess the biological effect of collagen scaffolds on the healing of extraction sockets MATERIALS AND METHODS: 20 healthy male New Zealand rabbits weighing about 2-2.5 kg, aged 14-16 weeks, was used in this study; their right mandibular first premolar was extracted and divided into two groups with 10 each, control group: sockets were left for normal healing without scaffold administration, collagen group: collagen plugs were administered to the socket. All the rabbits' sockets were dissected and processed for histological analysis. A scanning electron microscope was used to observe the surface morphology of the socket, and Energy dispersed x-ray analysis [EDXA] was used to analyze the calcium and phosphate levels. The information gathered was recorded, and statistical analysis was performed. RESULTS:The results (histology, scanning electron microscopy, and Energy dispersive X-ray analysis) revealed that the group with collagen plugs presented with more bone formation than the group with no scaffold placed in the socket. CONCLUSION: According to the findings of this study, collagen plugs used post-extraction in rabbits increased bone formation compared to sockets without plugs.

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“…They are usually manufactured by casting an aqueous collagen solution or gel into a mold and then freeze-dried. Changes in freezing regime, vacuum conditions, type of suspension, and presence of different additives or porogens can completely modify the porous structure, interconnectivity, and architecture of the resulting collagen sponge [ 59 , 60 ]. Even though these types of scaffolds have been extensively studied, clinically tested and some of them even globally commercialized, new technology is still being applied nowadays to increase the regenerative potential of collagen sponges.…”

Section: Forms Of Collagen Type I Biomaterials For Bone Tissue Engmentioning

confidence: 99%

Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering

et al. 2021

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Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration.

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Collagen‐Based Porous Scaffolds for Tissue Engineering

Cited by 4 publications

References 45 publications

Fabrication of Three-Dimensional Scaffolds Based on Nano-biomimetic Collagen Hybrid Constructs for Skin Tissue Engineering

Fabrication of Three-Dimensional Scaffolds Based on Nano-biomimetic Collagen Hybrid Constructs for Skin Tissue Engineering

Biological effect of collagen scaffolds on rabbit’s socket healing

Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering

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