Collagen and the effect of poly-l-lactic acid based materials on its synthesis

Abstract

Collagen is an important protein in various biological functions such as providing elasticity and waterproofing to the skin, structural stability to the cells in connective tissues (e.g. tendons, and bone)...

Fetuin A functionalisation of biodegradable PLLA-co-PEG nonwovens towards enhanced biomineralisation and osteoblastic growth behaviour

“…According to the literature, PLLA is known to increase collagen production. 38 Yet, our finding was a reduced amount of collagen I precursor in the supernatant in comparison with unmodified PLLA- co -PEG nonwovens. Since fetuin A promotes intrafibrillar mineralisation of collagen in vitro , 39 we assume that synthesised collagen precursors have been bound to fetuin A on the modified nonwovens, resulting in a reduced collagen I precursor concentration in the supernatants.…”

MiR-4458-loaded gelatin nanospheres target COL11A1 for DDR2/SRC signaling pathway inactivation to suppress the progression of estrogen receptor-positive breast cancer

“…11 Collagen is a major component and the most abundant protein in the ECM. 12 In vertebrates, 29 members of collagen composed of three α chains with a left-handed helix have been identified. They can be categorized into fibrillar collagens, nonfibril-forming collagens, and fibril-associated collagens.…”

Green Catalysts in the Synthesis of Biopolymers and Biomaterials

“…[46] Chafran et al used Keggin heteropolyacids, H 3 PW 12 O 40 .nH 2 O, supported on activated carbon (H 3 PW/C) by the evaporation impregnation method as heterogeneous catalysts in polymerization reactions of a racemic mixture of D,L-lactic acid in order to form the polymeric blend poly-D,Llactic acid that has great applicability both in the packaging industry and in the biomedical field as an absorbable, semipermanent, and injectable material that is able to gradually restore volume and stimulate collagen production. [47,48] In the method, until then unpublished in the literature, it was observed that the heterogeneous catalyst presented high enantioselectivity as a function of the L-lactic acid isomer, whose content in the polymeric chain increases as the reaction time varies, with predominance of the L configuration compared to the configuration D-lactic acid in the polymeric blend at approximately 85 % (reaction time 15 h). In addition, since it was a heterogeneous catalysis process, it was possible to recover the catalyst from the reaction medium by simple centrifugation processes and reuse it in new cycles.…”