Collaborative study of pregnancy rates following danazol therapy of stage I endometriosis

Butler, L.David; Wilson, Emery A.; Bélisle, Serge; Gibson, Mark; Albrecht, Bruce H.; Schiff, Isaac; Stillman, Robert J.

doi:10.1016/s0015-0282(16)47714-9

Cited by 16 publications

(1 citation statement)

References 10 publications

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“…Large retrospective studies of the efficacy of danazol have reported crude pregnancy *To whom correspondence should be addressed at: 24, Aheon Street, Agia Paraskevi, 15343 Athens, Greece. 0929-5666/$ 6.00 + 1.00 © 1996 ESCOM Science Publishers B.V. rates of 28-47% and monthly fecundity rates (when reported) have ranged from 4% to 6% [10][11][12][13][14][15]. Little information is available on the role of GnRH agonists to improve the reproductive prognosis in infertile women with endometriosis.…”

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confidence: 99%

Danazol versus [d-Trp6]GnRH agonist for the management of infertility due to atypical endometriosis

Tzingounis

Cardamakis

1996

Lett Pept Sci

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The aim of this study is to assess the impact of atypical endometriosis on fertility as well as the effect of treatment in endometriosis-related infertility. A prospective randomized study comparing the effects of triptorelin (Arvekap, Ipsen) and danazol (Danatrol, Winthrop) was completed recently. The 103 patients (aged 30.9_+4.92, range 21-41) who finished the study were divided into three comparable (infertility duration, age) groups. Group A (n = 37) received danazol (600 mg/day) for 6 months, Group B (n = 32) received triptorelin (3.75 mg) injections, one every 28 days for 6 months, and Group C (n = 34) did not receive any kind of treatment. More pregnancies were observed in Group B (65.62%) compared with Group C (20.58%, p= 0.00012) but not compared with Group A (54.05%, p = 0.05857). The overall monthly fecundity rate in Group B was 0.11, and differences concerning spontaneous abortion rates were not observed. Our results indicate that danazol and triptorelin are equally effective in the treatment of atypical endometriosis-related infertility.

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