Distribution quality management performance in supply chains is a key issue for overall performance and competitiveness. This paper proposes a methodology for analyzing distribution quality management performance using simulation and design of experiments (DOE). This methodology has four steps: (i) Selection of variables, (ii) Determination of factors and levels, (iii) Performing the experimental simulation and (iv) Analysis of the results. The joint application of simulation and DOE allowed analyzing the effects of the independent variables on the distribution quality management performance. It was also possible to sort the independent variables according to the degree of impact on the response variable.