Collaborative CuMn diatomic nanozyme to boost nanocatalytic/mild photothermal/chemo-therapy through overcoming therapeutic resistance

Li, Kunle; Miao, Yuqing; Song, Kai; He, Song; Zhang, Guiju; Waterhouse, Geoffrey I. N.; Guan, Shanyue; Zhou, Shuyun

doi:10.1016/j.cej.2023.144693

Cited by 9 publications

(1 citation statement)

References 42 publications

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“…Therefore, the combination with other antibacterial agents or strategies is necessary to enhance its efficiency. In recent years, chemodynamic therapy (CDT) has emerged as a promising treatment modality. − Fenton/Fenton-like reactions facilitate the conversion of H 2 O 2 into hydroxyl radicals, employing Fe and other metals with distinct valence states. When combined with photothermal therapy (PTT), this synergistic approach not only utilizes thermal energy to eradicate bacteria but also accelerates the generation of free radicals, thereby exhibiting synergistic antibacterial effects. , …”

Section: Introductionmentioning

confidence: 99%

Advancing NIR-II Photothermal Antibacterial Capability of Polydopamine Nanoparticles through Iron-Doped Molybdenum Oxide Functionalization

Fang,

Chang,

Jia

et al. 2024

ACS Appl. Nano Mater.

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Polydopamine (PDA) exhibits admirable photothermal properties and biocompatibility for biomedical applications; however, its near-infrared (NIR-II) absorption and antibacterial performance remain insufficient. Herein, we introduced Fe-doped molybdenum oxide (MoFeO x ) functionalized PDA composites exhibiting robust NIR absorption, reactive oxygen species (ROS) generation, and glutathione (GSH) depletion, thereby achieving a synergistic photothermal therapy/chemodynamic antibacterial effect. Polyethylenimine (PEI) served as the interlayer to bind MoFeO x onto the surface of PDA through electrostatic interaction. Compared with pure PDA, the nanoparticles demonstrated a 145% improvement in photothermal efficiency in the NIR-II range (1064 nm) when incorporating only 2.2% MoFeO x . This was attributed to the generation of electron "donor" and "acceptor" within the material, resulting in a reduction in the energy band gap and enhanced electron migration, as characterized by ultraviolet photoelectron spectroscopy (UPS). The nanoparticles exhibited synergistic therapeutic effects on E. coli and S. aureus through photothermal/chemodynamic therapy. This work offers an alternative methodology for improving the photothermal performance of PDA and designing synergistic antibacterial materials.

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Section: Introductionmentioning

confidence: 99%

Advancing NIR-II Photothermal Antibacterial Capability of Polydopamine Nanoparticles through Iron-Doped Molybdenum Oxide Functionalization

Fang,

Chang,

Jia

et al. 2024

ACS Appl. Nano Mater.

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Zn/Cu Bi‐Single‐Atom Nanoplatform: Hexagonal Anti‐Tumor Warrior by ROS Amplification for DOX Resistance Reversal and Immune Activation

Wang,

Zhang,

Guimarães

et al. 2024

Adv Funct Materials

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Severe resistance of doxorubicin (DOX) caused by drug efflux and immunosuppression has led to a high treatment failure risk of breast cancer (BC). Compared with the single atom nanozymes, the bi‐single‐atomic nanozymes obtained through sequential single‐atom synthesis strategy in different spaces of the same nanomaterial, can significantly improve the space utilization efficiency and catalytic capacity. In this study, bi‐single‐atom nanozymes (Zn/Cu‐BSAN‐DOX NPs) are designed to reverse BC DOX resistance by causing damage to mitochondria of mesenchymal stem cells (MSCs) and 4T1 cells through reactive oxygen species (ROS) amplification. In situ H2O2 self‐supply is improved by releasing DOX through activating the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs). ROS amplification is triggered by enhanced chemodynamic therapy (CDT) and sonodynamic therapy (SDT) of Zn/Cu‐BSAN, which efficiently reverses the DOX resistance by breaking the hyaluronic acid (HA) barrier and DOX efflux. Furthermore, ROS amplification significantly promotes the immune improvement including DCs maturation, T cell activation, and the polarization of M1 macrophage. In summary, as “hexagonal” anti‐tumor warrior, Zn/Cu‐BSAN‐DOX NPs show great potential for multimodal DOX‐resistant BC therapy, which further expands the new preparation strategy and the clinical anti‐tumor application paradigm of single‐atom nanozymes.

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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Xiong,

Zhu,

Zhao

et al. 2024

Small Methods

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Cascade reactions are described as efficient and versatile tools, and organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such as chromogenic detection, biosensing, tumor diagnosis, and therapy. However, how to selectively kill tumor cells by enzymatic reactions without harming normal cells, as well as exploring two or more enzyme‐engineered nanoreactors for cascading catalytic reactions, remain great challenges in the field of targeted and specific cancer diagnostics and therapy. The latest research advances in nanozyme‐catalyzed cascade processes for cancer diagnosis and therapy are described in this article. Here, various sensing strategies are summarized, for tumor‐specific diagnostics. Targeting mechanisms for tumor treatment using cascade nanozymes are classified and analyzed, “elements” and “dimensions” of cascade nanozymes, types, designs of structure, and assembly modes of highly active and specific cascade nanozymes, as well as a variety of new strategies of tumor targeting based on the cascade reaction of nanozymes. Finally, the integrated application of the cascade nanozymes systems in tumor‐targeted and specific diagnostic therapy is summarized, which will lay the foundation for the design of more rational, efficient, and specific tumor diagnostic and therapeutic modalities in the future.

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Collaborative CuMn diatomic nanozyme to boost nanocatalytic/mild photothermal/chemo-therapy through overcoming therapeutic resistance

Cited by 9 publications

References 42 publications

Advancing NIR-II Photothermal Antibacterial Capability of Polydopamine Nanoparticles through Iron-Doped Molybdenum Oxide Functionalization

Advancing NIR-II Photothermal Antibacterial Capability of Polydopamine Nanoparticles through Iron-Doped Molybdenum Oxide Functionalization

Zn/Cu Bi‐Single‐Atom Nanoplatform: Hexagonal Anti‐Tumor Warrior by ROS Amplification for DOX Resistance Reversal and Immune Activation

Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

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