This paper conducted a bibliometric analysis of personality and safety behavior research in the Web of Science database during the period of 2000−2023. A total of 1972 publications were screened from the Web of Science database, which covered 9992 authors, 867 journals, 114 countries/regions, and 3141 organizations. The annual growth trend and distribution of subject categories were analyzed. The most productive and influential countries, institutions, authors, and their cooperation networks were also identified. In addition, keywords occurrence was also provided. It is expected to provide the review for the past decades and significant insight to better understand the development trends associated with personality and safety behavior research.