Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity

Abstract

Our understanding of the pathophysiological mechanisms underlying chronic pain in inflammatory bowel disease is incomplete. Here we show that microbial manipulation modulates the development of visceral, but not somatic, pain in a mouse model of postinflammatory dextran sodium sulfate colitis. CONCLUSIONS:The microbiome plays a central role in postinflammatory visceral hypersensitivity. Microbial-derived SCFAs can sensitize nociceptive neurons and may contribute to the pathogenesis of postinflammatory visceral pain.

Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice

“…It has been reported that decreased Bifidobacterium and increased Escherichia could be observed in the fecal samples from patients with Alzheimer`s diseases and IBS patients [ 23 , 24 ]. Bifidobacterium and Lactobacillus have been shown to decrease the visceromotor response to colorectal distention in animal models [ 25 ]. We now also showed that probiotics including Bifidobacterium and Lactobacillus could relieve visceral hypersensitivity and mechanical allodynia.…”

Antibiotics-induced Intestinal Dysbacteriosis Caused Behavioral Alternations and Neuronal Activation in Different Brain Regions in Mice

“…Bi dobacterium and Lactobacillus have been shown to decrease the visceromotor response to colorectal distention in animal models (25). We now also showed that probiotics including Bi dobacterium and Lactobacillus could relieve visceral hypersensitivity and mechanical allodynia.…”

The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity

“…38 The increase of Lachnospiraceae and Ruminococcus was correlated with visceral pain. 42,47 Decrease of Lactobacilli occurred in patients with IBS-D, 44 constipation-predominant IBS was related to methane excretion. 43 Lactobacillus plantarum PS128 ameliorated VH through gut-brain axis.…”

“…However, Frost et al 26 found that there was no difference of fecal microbiota composition between IBS patients and controls. Because of different diagnostic criteria for IBS, 39 , 40 the different subtypes of IBS, 41 the different sampling sites and methods (luminal microflora and intestinal mucosa-associated microflora), 42 , 43 the evolution of the bacterial taxonomy, 44 limitations of methodology for analysis of the microbiota (culture-based methods, 41 real-time fluorescent quantitative PCR, 45 and 16S rRNA 44 ) and microbiota in different geographical environment, 46 there is no consistent conclusion about the relationship between intestinal microflora and IBS.…”