Colistimethate sodium therapy for multidrug‐resistant isolates in pediatric patients

Abstract

Colistimethate sodium appears to be safe and effective for the treatment of severe infections caused by multidrug-resistant P. aeruginosa or A. baumannii in pediatric patients.

Old agent, new experience: colistin use in the paediatric Intensive Care Unit—a multicentre study

“…In contrast to previous studies reporting a high frequency of nephrotoxicity [18,19,30], recent studies have found the incidence of nephrotoxicity to be 0-14.3% [2,5,8,10]. Nephrotoxicity was found to be relatively low (2.3%) in the current study.…”

“…The results of this study suggest that colistin is an effective antimicrobial agent in the treatment of life-threatening nosocomial infections caused by MDR Gram-negative bacteria (the favourable outcome rate was 83.9%). Previous paediatric studies have demonstrated the efficacy of colistin treatment for MDR Gram-negative bacterial infections as ranging from 70% to 86% [2,5,6,10,[15][16][17]. This rate is higher than those reported in adult studies [18,19].…”

“…The most commonly reported side effects associated with colistin are nephrotoxicity and neurotoxicity [2,5,29]. In contrast to previous studies reporting a high frequency of nephrotoxicity [18,19,30], recent studies have found the incidence of nephrotoxicity to be 0-14.3% [2,5,8,10].…”

“…The emergence of MDR Gram-negative nosocomial pathogens has resulted in a resurgence of interest in polymyxin antibiotics (particularly colistin), which exhibit rapid bactericidal effects on Gram-negative bacteria [5]. Colistin remains active against almost all strains of P. aeruginosa, Acinetobacter and Klebsiella spp.…”

“…Even so, no new drugs have been discovered to combat such microorganisms [4]. This situation has led to renewed interest in treatment using colistin, which has a bactericidal effect, although its clinical use has been limited due to side effects [2,[5][6][7]. A number of studies have been conducted on the systemic use of colistin in adults, mostly in critically ill patients [7][8][9].…”