Cold water cleaning of brain proteins, biofilm and bone – harnessing an ultrasonically activated stream

Birkin, Peter R.; Offin, Douglas G.; Vian, Christopher J. B.; Howlin, Robert P.; Dawson, Jonathan I.; Secker, T.J.; Hervé, R.; Stoodley, Paul; Oreffo, Richard O.C.; Keevil, C. W.; Leighton, Timothy G.

doi:10.1039/c5cp02406d

Cited by 26 publications

(29 citation statements)

References 37 publications

(39 reference statements)

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“…Another potential application to treat biofilm infections harnessing sound is an ultrasonically activated stream. Birkin et al (2015) reported that by applying low-amplitude ultrasound (135 kHz, 120À250 kPa) through a liquid stream directed at a surface, endogenous cavitation nuclei can be sufficiently activated at the solid/liquid interface to disrupt biofilm.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Lattwein

Shekhar

Kouijzer

et al. 2020

Ultrasound in Medicine & Biology

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Ultrasound has been developed as both a diagnostic tool and a potent promoter of beneficial bioeffects for the treatment of chronic bacterial infections. Bacterial infections, especially those involving biofilm on implants, indwelling catheters and heart valves, affect millions of people each year, and many deaths occur as a consequence. Exposure of microbubbles or droplets to ultrasound can directly affect bacteria and enhance the efficacy of antibiotics or other therapeutics, which we have termed sonobactericide. This review summarizes investigations that have provided evidence for ultrasound-activated microbubble or droplet treatment of bacteria and biofilm. In particular, we review the types of bacteria and therapeutics used for treatment and the in vitro and pre-clinical experimental setups employed in sonobactericide research. Mechanisms for ultrasound enhancement of sonobactericide, with a special emphasis on acoustic cavitation and radiation force, are reviewed, and the potential for clinical translation is discussed. (

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Lattwein

Shekhar

Kouijzer

et al. 2020

Ultrasound in Medicine & Biology

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“…• the cleaning of brain tissue and prions from surgical steel, the removal of contaminating material from bone transplants [33];…”

Section: Introductionmentioning

confidence: 99%

Acoustic radiation force on a parametrically distorted bubble

Leighton

2018

The Journal of the Acoustical Society of America

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The subject of acoustic radiation pressure on a gas bubble is important in many applications because it controls how bubbles are moved by acoustic fields to target locations, and often how they act upon the target. Previous theoretical treatments assume a spherical bubble undergoing linear pulsations, but some (such as cleaning using Faraday waves on the bubble wall) require that the bubble be aspherical. Therefore, this paper derives ways to calculate the variation in the radiation pressure due to the non-spherical bubble oscillations. The magnitude and direction of the radiation force are determined by two factors: the amplitude of volume oscillations, V, and the phase relationship between those oscillations and the acoustic field which drives them. There are two key findings that correct for the predictions of a model accounting for only linear pulsations. First, the growth of the radiation force slows down as V ceases to increase linearly with increasing amplitude of the acoustic wave above the threshold. Second, although both models show that the direction of the force relative of the standing wave antinode can be attractive or repulsive depending on frequency, when distortion modes are included the frequency at which this force changes its sign is shifted.

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“…This would then have the potential to either prevent or limit biofilm development, in addition to dispersing and treating any adherent cells already present in the wound bed. The transmission of US via a fluid stream to biotic and abiotic surfaces for the purpose of biological decontamination has recently demonstrated that clinical translation and utility in this field are achievable (Birkin et al ., , ). In order to achieve fundamental change in healthcare practices such as the treatment of chronic wounds, we believe this review exemplifies the need for collaborative and interdisciplinary research to potentiate existing therapies and develop novel treatment modalities.…”

Section: Multifunctional Agents For the Delivery Of Nitric Oxide To Bmentioning

confidence: 99%

Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge

LuTheryn

Glynne‐Jones

Webb

et al. 2019

Microbial Biotechnology

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Summary Bacterial biofilms are an ever‐growing concern for public health, featuring both inherited genetic resistance and a conferred innate tolerance to traditional antibiotic therapies. Consequently, there is a growing interest in novel methods of drug delivery, in order to increase the efficacy of antimicrobial agents. One such method is the use of acoustically activated microbubbles, which undergo volumetric oscillations and collapse upon exposure to an ultrasound field. This facilitates physical perturbation of the biofilm and provides the means to control drug delivery both temporally and spatially. In line with current literature in this area, this review offers a rounded argument for why ultrasound‐responsive agents could be an integral part of advancing wound care. To achieve this, we will outline the development and clinical significance of biofilms in the context of chronic infections. We will then discuss current practices used in combating biofilms in chronic wounds and then critically evaluate the use of acoustically activated gas microbubbles as an emerging treatment modality. Moreover, we will introduce the novel concept of microbubbles carrying biologically active gases that may facilitate biofilm dispersal.

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Cold water cleaning of brain proteins, biofilm and bone – harnessing an ultrasonically activated stream

Cited by 26 publications

References 37 publications

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Acoustic radiation force on a parametrically distorted bubble

Ultrasound‐mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge

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