Cold Shock Disrupts Massed Training-Elicited Memory in Drosophila

Bourouliti, Anna; Skoulakis, Efthimios M. C.

doi:10.3390/ijms23126407

Cited by 4 publications

(7 citation statements)

References 17 publications

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“…Furthermore, similar to Drosophila, massed conditioning in appetitive or aversive olfactory conditioning in the nematode worm Caenorhabditis elegans yields transcription- and translation-independent memory in contrast to spaced training, which is disrupted by protein synthesis inhibition [ 65 , 66 ]. Interestingly, in C. elegans , MC-yielded memory is sensitive to cold shock administered soon after training in agreement with the abovementioned results in a similar experimental scenario in Drosophila [ 25 ].…”

Section: Conservation Of Drosophila Arm/mc Memory Characteristics And...supporting

confidence: 87%

“…If MC memory and memory surviving cold-shock 2 h post training are equivalent, then delivering a cold-shock at least two hours after MC should not affect 24 h memory of the training. However, a cold shock delivered 2 h after MC was found to disrupt memory [ 25 ], suggesting that MC yields an additional memory type which consolidates slower than ARM since it is disrupted by cold shock. Therefore, this MC-elicited memory was termed Protein Synthesis-Independent Memory (PSIM) to differentiate it from bona fide ARM emerging after cold shock [ 25 ].…”

Section: Massed Conditioning Yields Arm and A Novel Protein Synthesis...mentioning

confidence: 99%

“…However, a cold shock delivered 2 h after MC was found to disrupt memory [ 25 ], suggesting that MC yields an additional memory type which consolidates slower than ARM since it is disrupted by cold shock. Therefore, this MC-elicited memory was termed Protein Synthesis-Independent Memory (PSIM) to differentiate it from bona fide ARM emerging after cold shock [ 25 ]. Whether PSIM represents a slow consolidating component of ARM elicited by the multiple training rounds, or a novel memory type is currently under investigation.…”

Section: Massed Conditioning Yields Arm and A Novel Protein Synthesis...mentioning

confidence: 99%

“…Another significant issue that needs to be addressed systematically given the recent finding that MC yields both ARM and PSIM [ 25 ] is to determine whether extant mutants affect both processes or not. A number, but not all, of these mutants affect both processes ( Table 3 ), and it is still unclear whether mutants or molecular pathways affect MC-elicited memories and which one, differentially.…”

Section: Molecular Mechanisms Differentially Engaged In Arm and Mc-el...mentioning

confidence: 99%

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Anesthesia Resistant Memories in Drosophila, a Working Perspective

Bourouliti

Skoulakis

2022

IJMS

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Memories are lasting representations over time of associations between stimuli or events. In general, the relatively slow consolidation of memories requires protein synthesis with a known exception being the so-called Anesthesia Resistant Memory (ARM) in Drosophila. This protein synthesis-independent memory type survives amnestic shocks after a short, sensitive window post training, and can also emerge after repeated cycles of training in a negatively reinforced olfactory conditioning task, without rest between cycles (massed conditioning—MC). We discussed operational and molecular mechanisms that mediate ARM and differentiate it from protein synthesis-dependent long-term memory (LTM) in Drosophila. Based on the notion that ARM is unlikely to specifically characterize Drosophila, we examined protein synthesis and MC-elicited memories in other species and based on intraspecies shared molecular components and proposed potential relationships of ARM with established memory types in Drosophila and vertebrates.

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Section: Conservation Of Drosophila Arm/mc Memory Characteristics And...supporting

confidence: 87%

Section: Massed Conditioning Yields Arm and A Novel Protein Synthesis...mentioning

confidence: 99%

Section: Massed Conditioning Yields Arm and A Novel Protein Synthesis...mentioning

confidence: 99%

Section: Molecular Mechanisms Differentially Engaged In Arm and Mc-el...mentioning

confidence: 99%

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Anesthesia Resistant Memories in Drosophila, a Working Perspective

Bourouliti

Skoulakis

2022

IJMS

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“…Two forms of consolidated memory can be elicited in Drosophila by repeated cycles of 12 odor/footshock pairings and assessed 24 h later. A protein synthesis-dependent memory (PSDM) was induced by 5 cycles of pairings spaced 15 min apart, while a protein synthesis independent memory (PSIM) was elicited by the same number of conditioning cycles but without the intervening rest interval [ 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS

Vourkou

Paspaliaris

Bourouliti

et al. 2022

IJMS

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Accumulation of highly post-translationally modified tau proteins is a hallmark of neurodegenerative disorders known as tauopathies, the most common of which is Alzheimer’s disease. Although six tau isoforms are found in the human brain, the majority of animal and cellular tauopathy models utilize a representative single isoform. However, the six human tau isoforms present overlapping but distinct distributions in the brain and are differentially involved in particular tauopathies. These observations support the notion that tau isoforms possess distinct functional properties important for both physiology and pathology. To address this hypothesis, the six human brain tau isoforms were expressed singly in the Drosophila brain and their effects in an established battery of assays measuring neuronal dysfunction, vulnerability to oxidative stress and life span were systematically assessed comparatively. The results reveal isoform-specific effects clearly not attributed to differences in expression levels but correlated with the number of microtubule-binding repeats and the accumulation of a particular isoform in support of the functional differentiation of these tau isoforms. Delineation of isoform-specific effects is essential to understand the apparent differential involvement of each tau isoform in tauopathies and their contribution to neuronal dysfunction and toxicity.

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Socialization causes long-lasting behavioral changes

Gil-Martí,

Isidro-Mézcua,

Poza-Rodriguez

et al. 2024

Sci Rep

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In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human, impacting aggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.

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Cold Shock Disrupts Massed Training-Elicited Memory in Drosophila

Cited by 4 publications

References 17 publications

Anesthesia Resistant Memories in Drosophila, a Working Perspective

Anesthesia Resistant Memories in Drosophila, a Working Perspective

Differential Effects of Human Tau Isoforms to Neuronal Dysfunction and Toxicity in the Drosophila CNS

Socialization causes long-lasting behavioral changes

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