Cold response of the bladder in guinea pig: Involvement of transient receptor potential channel, TRPM8

Tsukimi, Yasuhiro; Mizuyachi, Kaori; Yamasaki, Tsutomu; Niki, Toshiro; Hayashi, Fumio

doi:10.1016/j.urology.2004.10.006

Cited by 55 publications

(54 citation statements)

References 14 publications

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“…It has been suggested that TRPM8 serves as a cold sensor in the prostate (Stein et al 2004). Such a function has also recently been suggested for TRPM8 in the bladder (Tsukimi et al 2005). TRPM8 may also be involved in other functions such as the regulation of proliferation and/or apoptosis (and hence the control of cell number) and in ion and protein secretion in prostate epithelial cells (Zhang & Barritt 2004).…”

Section: Physiological Functions Of Trpm8 In Prostate Cancer Cellsmentioning

confidence: 96%

“…A low level of TRPM8 expression was also found in smooth muscle cells. In prostate epithelial cells, the highest level of TRPM8 expression was seen in the apical region of secretory epithelial cells, with much lower amounts In addition to normal prostate epithelium, TRPM8 is also detected in a number of urogenital tissues including testis, seminiferous tubules, scrotal skin, and bladder urothelium (Tsukimi et al 2005) (Table 1). This systemic expression profile implies that TRPM8 may have yet to be identified roles associated with reproduction and/or sexuality.…”

Section: Physiological Functions Of Trpm8 In Prostate Cancer Cellsmentioning

confidence: 99%

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TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?

Zhang

Barritt

2006

Endocr Relat Cancer

130

108

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During the past 5 years it has emerged that the transient receptor potential (TRP) family of Ca 2+ -and Na + -permeable channels plays a diverse and important role in cell biology and in pathology. One member of this family, TRPM8, is highly expressed in prostate cancer cells but the physiological and pathological functions of TRPM8 in these cells are not known. Here we address these questions, and the issue of whether or not TRPM8 is an effective diagnostic and prognostic marker in prostate cancer. TRPM8 is known to be activated by cool stimuli (17-25 C) and cooling compounds such as menthol. The activation mechanism(s) involves voltage sensing of membrane potential, phosphatidylinositol 4,5-bisphosphate and Ca 2+. In addition to prostate cancer cells, TRPM8 is expressed in sensory neurons where it acts as a sensor of cold. In prostate epithelial cells, expression of TRPM8 is regulated by androgen and is elevated in androgen-sensitive cancerous cells compared with normal cells. While there is some evidence that in prostate cancer cells Ca 2+ and Na + inflow through TRPM8 is necessary for survival and function, including secretion at the apical membrane, the function of TRPM8 in these cells is not really known. It may well differ from the role of TRPM8 as a cool sensor in sensory nerve cells. Androgen unresponsive prostate cancer is difficult to treat effectively and there are limited diagnostic and prognostic markers available. TRPM8 is a potential tissue marker in differential diagnosis and a potential prognostic marker for androgen-unresponsive and metastatic prostate cancer. As a consequence of its ability to convey Ca 2+ and Na + and its expression in only a limited number of cell types, TRPM8 is considered to be a promising target for pharmaceutical, immunological and genetic interventions for the treatment of prostate cancer.

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Section: Physiological Functions Of Trpm8 In Prostate Cancer Cellsmentioning

confidence: 96%

Section: Physiological Functions Of Trpm8 In Prostate Cancer Cellsmentioning

confidence: 99%

TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?

Zhang

Barritt

2006

Endocr Relat Cancer

130

108

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“…8 In guinea pigs, TRPM8 has been detected in S1 dorsal root ganglia (DRG). 9 TRPM8 expression studies in the rat showed the presence of TRPM8 not only in prostate but also in testis, penis, bladder, and L6-S1 DRG tissue. 6 Epidermal expression of TRPM8 has yet to be demonstrated.…”

Section: Introductionmentioning

confidence: 96%

Stimulation of skin menthol receptors stimulates detrusor activity in conscious rats

Chen

Ishizuka

Imamura

et al. 2009

Neurourology and Urodynamics

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“…Expression of other TRP channels, e.g., TRPM8 and TRPA1, is found in sensory C fibers in the bladder (27,28). TRPM8 forms the basis of the diagnostic ice water test to determine whether disturbance of bladder function involves a neurogenic component (29).…”

Section: Introductionmentioning

confidence: 99%

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

Gevaert¹,

Vriens²,

Segal³

et al. 2007

J. Clin. Invest.

290

349

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Here we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function. Immunofluorescence demonstrated TRPV4 expression in mouse and rat urothelium and vascular endothelium, but not in other cell types of the bladder. Intracellular Ca 2+ measurements on urothelial cells isolated from mice revealed a TRPV4-dependent response to the selective TRPV4 agonist 4α-phorbol 12,13-didecanoate and to hypotonic cell swelling. Behavioral studies demonstrated that TRPV4 -/-mice manifest an incontinent phenotype but show normal exploratory activity and anxietyrelated behavior. Cystometric experiments revealed that TRPV4 -/-mice exhibit a lower frequency of voiding contractions as well as a higher frequency of nonvoiding contractions. Additionally, the amplitude of the spontaneous contractions in explanted bladder strips from TRPV4 -/-mice was significantly reduced. Finally, a decreased intravesical stretch-evoked ATP release was found in isolated whole bladders from TRPV4 -/-mice. These data demonstrate a previously unrecognized role for TRPV4 in voiding behavior, raising the possibility that TRPV4 plays a critical role in urothelium-mediated transduction of intravesical mechanical pressure.

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Cold response of the bladder in guinea pig: Involvement of transient receptor potential channel, TRPM8

Cited by 55 publications

References 14 publications

TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?

TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?

Stimulation of skin menthol receptors stimulates detrusor activity in conscious rats

Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding

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