Cold Reactive Proteins in Cardiovascular Surgery

Abstract

Background: According to the literature, Cryoglobins, Cold Agglutinins, Donath-Landsteiner antibodies, and Cryofibrinogen arethe 4 types of Cold-Reactive proteins described. Objective: The aim of the study was to show the role of these proteins cardiovascular surgery. Case presentation: A 57-year-old male patient with a history of myocardial infarction 6 years ago, heavy smoker until 1 year ago, with diabetes, was admitted to the hospital for a surgical confrontation of coronary disease. He reports that for1-month symptoms are deteriorating (NYHA III). The history of the patient does not include either hematopoietic system or connective tissue diseases or recent viral infection. Angiographic control showed total obstruction of the small branch. The patient underwent median sternotomy. Suspension of the left sternum. Mobilization of the left internal mammary artery. Concomitant reception of left great saphenous vein. Intubation of ascending aorta and right atrium – vena cava with acatheter of two steps. He was extubated at the 10th post-surgical hour. Smooth post-surgical progression, with no signs of brain, myocardial or renal failure. The patient was discharged on the 5th post-surgical day. Conclusion: Independently of the technique that is used, the systemic temperature must be maintained duringthe cardiopulmonary bypass above the temperature threshold activity of the cold-reactiveproteins.

Cryoglobulinemia: the “cold” problem in cardiac surgery, a single-center experience and a literature review

“…Regarding Chronic or Acute coronary disease three cases were reported by Faikh et al [34], Saifullah et al [35], and Panagiotoupulos et al [36].…”

“…In December 2022, Panagiotoupulos et al [36] published a recent case report in literature with a CABG of a 57-year-old man with no story of Cryoglobulinemia or Cold hemagglutinin disease. CPB was performed as usual when, suddenly, blood clots appeared on the surgical field.…”