Cold-pressed raspberry seeds oil ameliorates high-fat diet triggered non-alcoholic fatty liver disease

Hendawy, Omnia M.; Gomaa, Hesham A.M.; Hussein, Shaimaa; Alzarea, Sami I.; Qasim, Sumera; Rahman, Fatema El-Zahraa S. Abdel; Ali, Asmaa T.; Ahmed, Shaimaa R.

doi:10.1016/j.jsps.2021.09.014

Cited by 13 publications

(14 citation statements)

References 46 publications

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“…No less important, the antioxidant determined in plant tissues as well as in animals is vitamin E (tocopherols), for which the antioxidant activity is concentration-dependent [ 43 ]. According to Hendawy et al’s [ 44 ] research data, the total tocopherol content in cold-pressed raspberry seeds’ oil is 185.1 mg 100 g −1 oil. Mildner-Szkudlarz et al [ 45 ] provided data that raspberry seeds contain about 235.37 mg 100 g −1 oil of total tocopherols, while according to Li et al [ 46 ], in blackberry seeds the total tocopherols are 28.63 mg 100 g −1 oil.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Berry Pomace on Quality Changes of Beef Patties during Refrigerated Storage

Tarasevičienė

Čechovičienė

Paulauskienė

et al. 2022

Foods

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This study aims to evaluate the ability of raspberry and blackberry pomace to inhibit lipid oxidation and prolong the refrigerated storage of beef patties. Berry pomace was incorporated into beef patties at the concentration of 1, 3, and 5%. Packed patties were stored for 9 days at 4 °C temperature and the quality of the meat was evaluated on the 0, 3rd, 6th, and 9th day. The natural mass loss during storage, the pH as well as the lipid oxidation were evaluated by thiobarbituric acid-reactive substance (TBARS) method. GC was used to determine the amount of fatty acids and e-nose, based on ultrafast gas chromatography, was used for the determination of volatile organic compounds in beef patties before and after the storage. The highest mass loss during refrigerated storage was observed in the control beef patties, while the berry pomace absorbed water and reduced the loss. The pomace additive influenced the decrease in the patties pH during the storage. Berry pomace can be very effective in relation to lipid oxidation, and as little as 1% of berry pomace influenced the decrease in the TBAR’s values in the patties stored for nine days by 3.06 and 2.42 times, depending on the pomace compared to the control patties. The use of berry pomace in meat products can reduce lipid oxidation, increase their fiber content and act as a thickener, as well as contribute to the usage of agri-food by-products.

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Section: Resultsmentioning

confidence: 99%

The Effect of Berry Pomace on Quality Changes of Beef Patties during Refrigerated Storage

Tarasevičienė

Čechovičienė

Paulauskienė

et al. 2022

Foods

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“…Improving ALA metabolism and increasing serum ALA levels help treat metabolism-related diseases. Raspberry seed oil (RO) with a high level of ALA (25.98%) could effectively treat the HFFD-induced NAFLD mice (Hendawy et al, 2021). Han et al found that the intervention of ALA could activate the AMPK signaling and further improve mitochondrial dysfunction and oxidative stress, treating NAFLD mice induced by HFFD (Han et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice via Gut Microbiota

Yan

Nie

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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AimTo investigate the treating effect of Yiqi-Bushen-Tiaozhi (YBT) recipe on nonalcoholic steatohepatitis (NASH) mice, determine whether the outcome was associated with gut microbiota, and clarify the regulating mechanism.MethodsNASH mice were induced by high-fat and high-fructose diets (HFFD). In the fifth week, mice in the YBT group were orally administrated YBT (22.12g·kg-1·d-1) daily for 12 weeks. Fresh stool of mice was collected at the 16th week for fecal 16S rDNA analysis. Hepatic pathology and biochemical indicators were used to reflect the improvement of YBT on hepatic inflammation and lipid metabolism in NASH mice. Quantitative real-time PCR (qRT-PCR) was used to verify the results of PICRUSt analysis.ResultsResults of the pathological and biochemical index showed that YBT could improve NASH mice. Compared with improving inflammation and hepatocyte damage, YBT may be more focused on enhancing metabolic disorders in mice, such as increasing HDL-c level. The diversity and richness of the gut microbiota of NASH mice induced by HFFD are significantly different from the normal control (NC) group. After YBT treatment, the diversity and richness of the mice microbiota will be increased to similar NC mice. Intestinimonas, Acetatifactor, Alistipes, Intestinimonas, Acetatifactor, and Alistipes have the most significant changes in the class level. PICRUSt analysis was performed to predict genomic functions based on the 16S rDNA results and reference sequencing. The efficacy of YBT in the treatment of NASH can be achieved by regulating the diversity and richness of gut microbiota. PICRUSt analysis results showed that the most relevant function of the microbiota construction variations is α- Linolenic acid (ALA) metabolism. Results of qRT-PCR showed significant differences between groups in the expression of Fatty acid desaturase 1 (FADS1), Fatty acid desaturase 2 (FADS2), Acyl-CoA Oxidase 1 (ACOX1), and Acyl-CoA Oxidase 2 (ACOX2) related to ALA metabolism. The expression of the above genes will be inhibited in the liver and small intestine of the HFFD group mice, and the expression can be restored after YBT treatment.ConclusionYBT could treat NASH mice by improving the diversity and richness of gut microbiota and further the improvement of ALA metabolism.

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“…Hendawy et al studied the effect of cold-pressed raspberry seed oil on non-alcoholic fatty liver disease (NAFLD) in male Wistar rats [ 47 ]. NAFLD is a pathologic condition of the liver characterized by excessive deposition of fat in hepatocytes.…”

Section: Health-promoting Properties Of Berry Seeds—in Vitro and In V...mentioning

confidence: 99%

“…It is correlated with type II diabetes, obesity, insulin resistance, elevated serum lipoproteins, and hypertension, and can lead to permanent liver damage. As NAFLD is a problem that affects 7–37% of adults and 20–30% of children worldwide, and currently used drugs (anti-obesity, antidiabetic, antioxidant, and antihyperlipidemic) can cause adverse effects, researchers are still searching for new ways of prevention and treatment of this disease [ 47 , 48 ]. Raspberry oil has a good ratio of n -6 and n -3 fatty acids (2–3:1) and contains γ-tocopherol, linolenic acid, polyphenols, and carotenoids, so it was chosen as a potential candidate [ 6 , 47 , 49 ].…”

Section: Health-promoting Properties Of Berry Seeds—in Vitro and In V...mentioning

confidence: 99%

“…As NAFLD is a problem that affects 7–37% of adults and 20–30% of children worldwide, and currently used drugs (anti-obesity, antidiabetic, antioxidant, and antihyperlipidemic) can cause adverse effects, researchers are still searching for new ways of prevention and treatment of this disease [ 47 , 48 ]. Raspberry oil has a good ratio of n -6 and n -3 fatty acids (2–3:1) and contains γ-tocopherol, linolenic acid, polyphenols, and carotenoids, so it was chosen as a potential candidate [ 6 , 47 , 49 ]. Rats were fed 0.4 or 0.8 mL of raspberry seed oil (3 times a week for 8 weeks) in addition to a high-fat diet (HFD).…”

Section: Health-promoting Properties Of Berry Seeds—in Vitro and In V...mentioning

confidence: 99%

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A Review on Berry Seeds—A Special Emphasis on Their Chemical Content and Health-Promoting Properties

2023

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Berries are important components of the human diet, valued for their high content of nutrients and active compounds. Berry seeds are also important objects of scientific investigation as, in some cases, they can have a higher concentration of certain phytochemicals than other parts of the fruit. Moreover, they are often byproducts of the food industry that can be reused to make oil, extracts, or flour. We have reviewed available literature related to the chemical content and biological activity of seeds from five different berry species—red raspberry (Rubus idaeus L. and Rubus coreanus Miq.), strawberry (Fragaria x ananassa), grape (Vitis vinifera L.), sea buckthorn (Hippophae rhamnoides L.), and cranberry (Vaccinium macrocarpon Ait.). We have searched various databases, including PubMed, Web of Knowledge, ScienceDirect, and Scopus. Last search was conducted on 16.01.2023. Various preparations from berry seeds are valuable sources of bioactive phytochemicals and could be used as functional foods or to make pharmaceuticals or cosmetics. Some products, like oil, flour, or extracts, are already available on the market. However, many preparations and compounds still lack appropriate evidence for their effectiveness in vivo, so their activity should first be assessed in animal studies and clinical trials.

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Cold-pressed raspberry seeds oil ameliorates high-fat diet triggered non-alcoholic fatty liver disease

Cited by 13 publications

References 46 publications

The Effect of Berry Pomace on Quality Changes of Beef Patties during Refrigerated Storage

The Effect of Berry Pomace on Quality Changes of Beef Patties during Refrigerated Storage

Yiqi-Bushen-Tiaozhi Recipe Attenuated High-Fat and High-Fructose Diet Induced Nonalcoholic Steatohepatitis in Mice via Gut Microbiota

A Review on Berry Seeds—A Special Emphasis on Their Chemical Content and Health-Promoting Properties

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