Cold plasma as a potential treatment for parapsoriasis: A case report

Abstract

Parapsoriasis is a group of uncommon dermatoses characterized by erythematous patches of variable sizes with acute and chronic variants which seem to be resistant to treatment. 1 Parapsoriasis is thought to be of T-cell origin which tends to overlap or coexist with other clonal T-cell-related pathologies like mycosis fungoides. 1,2 Cold plasma is a relatively new treatment (started in the mid-1990s) and is used in a variety of areas, including wound healing, cancer treatment, and the inactivation of antibiotic-resistant bacteria, such as MRSA and clostridium difficile. 3 This report presents a successful treatment of recalcitrant parapsoriasis with the application of cold plasma.A 34-year-old female patient presented to our clinic (Dermatology clinic, Shohada-e Tajrish Hospital) with mildly pruritic pink patches of two-year duration involving the trunk and lower extremities.Since 4 years ago, the patient has received systemic medication for rheumatoid arthritis. She was treated with azathioprine, prednisolone, hydroxychloroquine, and sulfasalazine for 4 months; because of changes in vision, hydroxychloroquine was deceased. The course of rheumatoid arthritis was improved gradually; and azathioprine, prednisolone, and sulfasalazine have been tapered off over the 2 years.

Demographics and Clinical Insights into Parapsoriasis in Benin City, Nigeria

“…Our study corroborates the heterogeneous clinical presentation of parapsoriasis, as reflected in the diverse appearance of skin lesions among participants. Hyperpigmented lesions, often accompanied by scales, were the most prevalent, consistent with the characteristic appearance of parapsoriasis [8]. Notably, pruritus (itching) was a frequent symptom, highlighting the significant impact that parapsoriasis can place on patients' quality of life of affected subjects.…”