Cold ischemic injury, aortic allograft vasculopathy, and pro-inflammatory cytokine expression

Knight, Richard J.; Liu, Hui; Fishman, Eric; Reis, Ernane D.

doi:10.1016/s0022-4804(03)00199-9

Cited by 11 publications

(10 citation statements)

References 15 publications

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“…Since cold ischemia time is a risk factor for late transplant loss, this study was primarily undertaken to show that cold preservation alone can give rise to profound intimal hyperplasia, even in the absence of an allo‐immune response. Hence, our study emphasizes the pivotal role of cold preservation damage on vascular remodeling and is in line with previous studies on the influence of cold preservation on vascular function and remodeling [31,32]. Our studies are also in line with a recent report by Nakao et al.…”

Section: Discussionsupporting

confidence: 93%

CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in rats

Song

Hoeger

Hillebrands

et al. 2010

Transplant International

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Summary Allograft vasculopathy is the leading cause for chronic transplant loss. We investigated if the addition of carbon monoxide releasing molecules (CORMs) to the preservation solution would protect the endothelium from cold preservation injury in an aortic transplantation model. In particular, we tested if CORM preserve vascular functioning and limit neo‐intima formation following cold preservation (Cp). Abdominal aortas from Lewis or Fisher rats were subjected to Cp in University of Wisconsin (UW) solution to which 50 μm of CORM‐3 was added or not. Hereafter, whole mount staining, acetylcholine mediated vasorelaxation (AMV) and aortic transplantation was performed. In vitro CORM‐3 protected human umbilical vein endothelial cells from Cp injury and prevented denudation and intercellular gap formation in aortic grafts. Cp resulted in loss of AMV of aorta segments. By contrast, AMV was preserved after the addition of CORM‐3 during Cp. Two months after transplantation Cp of aorta grafts resulted in an increased adventitial remodelling and neo‐intima formation. This was significantly blunted by CORM‐3 in syngeneic recipients. Our study demonstrates that addition of CORM‐3 to UW solution prevents endothelial damage, thereby maintaining vascular function directly after cold preservation. Hence, our findings might offer a novel strategy to prevent vascular damage during CP.

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Section: Discussionsupporting

confidence: 93%

CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in rats

Song

Hoeger

Hillebrands

et al. 2010

Transplant International

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“…Low temperature could also increase the proportion (IL-12/IL-10 and TNF-a/IL-10) of proinflammatory cytokines that leading to inflammation. On the other hand, cold stimulation could induce the activity of SLE by inducing cell apoptosis [15][16][17][18][19][20]. Consistent with this, we found that there were more active SLE patients in winter and spring; this may be due to increasing opportunities that the SLE patients exposure to cold stimulation so that proinflammatory cytokines accumulated in the body and increased clinical symptoms.…”

Section: Discussionsupporting

confidence: 83%

Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors

Yang

Pan

et al. 2011

Rheumatol Int

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Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a variety of clinical manifestations. Although inter-individual variations exist with respect to susceptibility to develop SLE, no study has been carried out to determine the role of different climate conditions in predisposing the susceptible individuals to SLE. The objective of this study was to investigate the role of different seasons and climate factors on SLE activity. From 2000 to 2009, the seasonal distribution of 2,802 active SLE patients recruited from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University was analyzed retrospectively. The climate data were provided by the Institute of Geographical Sciences and Resources, Chinese Academy of Sciences. The correlation between climate factors and SLE activity was also analyzed. The proportion of active SLE patients in winter, spring, summer, and autumn was 10.06, 10.31, 9.74, and 8.66‰, respectively. In autumn, the proportion was much lower than that in winter and spring (P < 0.05). The proportion among winter, spring, and summer had no statistical difference (P > 0.05). The number of active SLE patients had no correlation with air temperature (r = 0.483, P > 0.05), relative humidity (r = -0.294, P > 0.05), and sunshine percentage (r = 0.503, P > 0.05), but it had positive correlation with amount of precipitation (r = 0.601, P < 0.05), wind velocity (r = 0.713, P < 0.01), and sunshine duration (r = 0.769, P < 0.01) and negative correlation with barometric pressure (r = -0.664, P < 0.05). The disease activity of patients with SLE is affected by seasons and climate factors.

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“…[37][38][39] On the other hand, cold stimulation could induce the injury of blood vessels that may aggravate the renal vasculopathy induced by SLE. 40 In contrast to adaptive compensatory increases in RBC production observed in healthy people after exposure to systemic hypoxia at high altitudes, 41 we found that the RBC counts and hemoglobin level in patients at high altitudes were lower than those at moderate and/or low altitudes, although there was no significant association between altitudes and hematologic changes as shown in Table 1. In contrast, we observed the lowest level of platelet counts in patients at high altitudes, which were consistent with changes of platelet counts in the normal population affected by high altitudes.…”

Section: Discussioncontrasting

confidence: 57%

Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences

Qian

Ran

Zhou

et al. 2014

Lupus

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The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ system was recorded using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). There was no significant correlation between SLE activity and altitudes (r = 0.003, p = 0.159). Age at onset for SLE patients at high altitudes was significantly younger than that at low and moderate altitudes (p = 0.022 and p = 0.004, respectively). Age at SLE admission at low altitudes was significant older than those at moderate and high altitudes (p = 0.011 and p < 0.001, respectively). Patients at high altitudes had shorter duration from disease onset to admission than those at moderate altitudes (p = 0.009). Incidence of Sm antibodies-positive for resident patients at high altitudes was 36.4%, which were higher than that at moderate altitudes (p = 0.003). We found increasing trends of CNS activity in active patients; immunological and renal activities in inactive patients were correlated with elevated altitudes (p = 0.024, p = 0.004, p = 0.005), while arthritis scores in active patients showed the tendency of decreasing with the rise of elevation (p = 0.002). Hemoglobin level, red blood cell and platelet counts at high altitudes were significantly lower than those at low altitudes (p < 0.05, respectively). There was no significant difference in hemoglobin level between moderate- and low-altitude groups (p > 0.05). No significant difference in platelet counts between moderate- and high-altitude groups was observed (p > 0.05). Our findings suggest that some clinical features, laboratory tests and activity of main organs in SLE are influenced by altitudes. Furthermore, organ activities of active and inactive SLE patients have different patterns of altitudinal variations. These distinctive variations likely reveal that peculiar environmental factors at high altitudes can affect the development of SLE.

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Cold ischemic injury, aortic allograft vasculopathy, and pro-inflammatory cytokine expression

Cited by 11 publications

References 15 publications

CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in rats

CORMs protect endothelial cells during cold preservation, resulting in inhibition of intimal hyperplasia after aorta transplantation in rats

Seasonal distribution of systemic lupus erythematosus activity and its correlation with climate factors

Systemic lupus erythematosus patients in the low-latitude plateau of China: altitudinal influences

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