Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice

Evangelakos, Ioannis; Kuhl, Anastasia; Baguhl, Miriam; Schlein, Christian; John, Clara; Rohde, Julia K.; Heine, Markus; Heeren, Joerg; Worthmann, Anna

doi:10.3389/fcell.2022.836741

Cited by 3 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparing to thermoneutrality-housing [ 160 ], cold exposure stimulates bile acid synthesis through induction of CYP7A1 [ 161 ], CYP8B1, CYP7B1 and CYP27A1 [ 162 , 163 ]. This is accompanied by changes in the microbiota composition and functionality [ 162 ].…”

Section: Strategies To Modulate the Bile Acid Poolmentioning

confidence: 99%

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Gillard

Leclercq

2023

Clinical Science

View full text Add to dashboard Cite

Bile acids synthesized within the hepatocytes are transformed by gut microorganisms and reabsorbed into the portal circulation. During their enterohepatic cycling, bile acids act as signaling molecules by interacting with receptors to regulate pathways involved in many physiological processes. The bile acid pool, composed of a variety of bile acid species, has been shown to be altered in diseases, hence contributing to disease pathogenesis. Thus, understanding the changes in bile acid pool size and composition in pathological processes will help to elaborate effective pharmacological treatments. Five crucial steps along the enterohepatic cycle shape the bile acid pool size and composition, offering five possible targets for therapeutic intervention. In this review, we provide an insight on the strategies to modulate the bile acid pool, and then we discuss the potential benefits in non-alcoholic fatty liver disease.

show abstract

Section: Strategies To Modulate the Bile Acid Poolmentioning

confidence: 99%

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Gillard

Leclercq

2023

Clinical Science

View full text Add to dashboard Cite

show abstract

Cold environments and human metabolism: A traditional chinese medicine perspective

Zhao,

Ma,

Zhang

et al. 2024

Frigid Zone Medicine

View full text Add to dashboard Cite

The concept of Traditional Chinese Medicine (TCM) emphasizes the intrinsic connection between human beings and nature, positing that the human body undergoes distinct physiological changes in response to various natural environments. Cold, as a primary external factor in cold areas, necessitates the body’s autonomous adaptation to uphold optimal living conditions. The repercussions of cold on the body are both far-reaching and profound, with metabolic equilibrium adjustments playing a pivotal role. This article, rooted in the TCM principle of Yin-Yang balance, delves into the metabolic intricacies and adaptive responses to the human body in cold environments. The effects manifest in heat-producing tissues, systemic substance consumption, the blood substance concentrations, liver function, and metabolic rhythms. The article subsequently presents TCM recommendations for maintaining health in cold climates. It concludes by advocating the exploration of metabolic homeostasis changes as a key avenue for investigating the metabolic traits s of populations in cold regions. We posit that such insights will enhance comprehension of the metabolic shifts in cold region populations and advance the evolution of regional medicine.

show abstract

Bioinformatics prediction and experimental verification of key biomarkers for diabetic kidney disease based on transcriptome sequencing in mice

Zhao

et al. 2022

PeerJ

View full text Add to dashboard Cite

Background Diabetic kidney disease (DKD) is the leading cause of death in people with type 2 diabetes mellitus (T2DM). The main objective of this study is to find the potential biomarkers for DKD. Materials and Methods Two datasets (GSE86300 and GSE184836) retrieved from Gene Expression Omnibus (GEO) database were used, combined with our RNA sequencing (RNA-seq) results of DKD mice (C57 BLKS-32w db/db) and non-diabetic (db/m) mice for further analysis. After processing the expression matrix of the three sets of data using R software “Limma”, differential expression analysis was performed. The significantly differentially expressed genes (DEGs) (—logFC— > 1, p-value < 0.05) were visualized by heatmaps and volcano plots respectively. Next, the co-expression genes expressed in the three groups of DEGs were obtained by constructing a Venn diagram. In addition, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were further analyzed the related functions and enrichment pathways of these co-expression genes. Then, qRT-PCR was used to verify the expression levels of co-expression genes in the kidney of DKD and control mice. Finally, protein-protein interaction network (PPI), GO, KEGG analysis and Pearson correlation test were performed on the experimentally validated genes, in order to clarify the possible mechanism of them in DKD. Results Our RNA-seq results identified a total of 125 DEGs, including 59 up-regulated and 66 down-regulated DEGs. At the same time, 183 up-regulated and 153 down-regulated DEGs were obtained in GEO database GSE86300, and 76 up-regulated and 117 down-regulated DEGs were obtained in GSE184836. Venn diagram showed that 13 co-expression DEGs among the three groups of DEGs. GO analysis showed that biological processes (BP) were mainly enriched inresponse to stilbenoid, response to fatty acid, response to nutrient, positive regulation of macrophage derived foam cell differentiation, triglyceride metabolic process. KEGG pathway analysis showed that the three major enriched pathways were cholesterol metabolism, drug metabolism–cytochrome P450, PPAR signaling pathway. After qRT-PCR validation, we obtained 11 genes that were significant differentially expressed in the kidney tissues of DKD mice compared with control mice. (The mRNA expression levels of Aacs, Cpe, Cd36, Slc22a7, Slc1a4, Lpl, Cyp7b1, Akr1c14 and Apoh were declined, whereas Abcc4 and Gsta2 were elevated). Conclusion Our study, based on RNA-seq results, GEO databases and qRT-PCR, identified 11 significant dysregulated DEGs, which play an important role in lipid metabolism and the PPAR signaling pathway, which provide novel targets for diagnosis and treatment of DKD.

show abstract

Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice

Cited by 3 publications

References 50 publications

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Biological tuners to reshape the bile acid pool for therapeutic purposes in non-alcoholic fatty liver disease

Cold environments and human metabolism: A traditional chinese medicine perspective

Bioinformatics prediction and experimental verification of key biomarkers for diabetic kidney disease based on transcriptome sequencing in mice

Contact Info

Product

Resources

About