Cold‐induced ependymin expression in zebrafish and carp brain: implications for cold acclimation

Tang, Shanshan; Sun, Kien-Wen; Sun, Guang; Lin, Guang; Lin, Wen; Chuang, Mei Jan

doi:10.1016/s0014-5793(99)01229-6

Cited by 40 publications

(33 citation statements)

References 36 publications

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“…1B). S100␤, an astrocyte produced molecule in brain trauma, suppresses oxidative cell damage and performs neurotrophic and neuroprotective functions (16), matrix metalloproteinases are involved in extracellular matrix remodeling during damaged neuronal tissue recovery (17), and the cell matrix adhesion protein ependymin exhibits cold-induced up-regulation in the brain of two teleost fishes (18). The top 12 all-tissue transcripts (Fig.…”

Section: Resultsmentioning

confidence: 99%

Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish

Chen

Cheng

Zhang

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

226

215

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The antifreeze glycoprotein-fortified Antarctic notothenioid fishes comprise the predominant fish suborder in the isolated frigid Southern Ocean. Their ecological success undoubtedly entailed evolutionary acquisition of a full suite of cold-stable functions besides antifreeze protection. Prior studies of adaptive changes in these teleost fishes generally examined a single genotype or phenotype. We report here the genome-wide investigations of transcriptional and genomic changes associated with Antarctic notothenioid cold adaptation. We sequenced and characterized 33,560 ESTs from four tissues of the Antarctic notothenioid Dissostichus mawsoni and derived 3,114 nonredundant protein gene families and their expression profiles. Through comparative analyses of same-tissue transcriptome profiles of D. mawsoni and temperate/tropical teleost fishes, we identified 177 notothenioid protein families that were expressed many fold over the latter, indicating cold-related up-regulation. These up-regulated gene families operate in protein biosynthesis, protein folding and degradation, lipid metabolism, antioxidation, antiapoptosis, innate immunity, choriongenesis, and others, all of recognizable functional importance in mitigating stresses in freezing temperatures during notothenioid life histories. We further examined the genomic and evolutionary bases for this expressional up-regulation by comparative genomic hybridization of DNA from four pairs of Antarctic and basal non-Antarctic notothenioids to 10,700 D. mawsoni cDNA probes and discovered significant to astounding (3-to >300-fold, P < 0.05) Antarctic-specific duplications of 118 protein-coding genes, many of which correspond to the up-regulated gene families. Results of our integrative tripartite study strongly suggest that evolution under constant cold has resulted in dramatic genomic expansions of specific protein gene families, augmenting gene expression and gene functions contributing to physiological fitness of Antarctic notothenioids in freezing polar conditions. cold adaptation ͉ comparative genomics ͉ gene duplication ͉ genome evolution ͉ retrotransposon

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Section: Resultsmentioning

confidence: 99%

Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish

Chen

Cheng

Zhang

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

226

215

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“…The physiological roles of EpenAj have not been clearly elucidated yet. They are presumed to undergo an enhanced expression during neuroplasticity in memory consolidation (Shashoua, 1991;Rother et al, 1995;Pradel et al, 1999) and optic nerve regeneration (Schmidt & Shashoua, 1988) and in cold stress (Tang et al, 1999). Ependymin has been evidenced extensively as an important molecule of extracellular matrix (ECM), which responds to calcium level (Shashoua, 1991;Ganss & Hoffmann, 1993;Pradel et al, 1999).…”

Section: Isolation Of Epenaj Encoding Genementioning

confidence: 99%

Comparative analysis of genes expressed in regenerating intestine and non-eviscerated intestine of Apostichopus japonicus Selenka (Aspidochirotida: Stichopodidae) and cloning of ependymin gene

et al. 2006

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The regeneration of the intestine of sea cucumber (Apostichopus japonicus) was studied by describing historically the changes that occurred during intestine regeneration on the fifth day after chemicallyinduced evisceration. An expressed sequence tag (EST) analysis was undertaken to identify major genes, which might be involved in intestine regeneration of A. japonicus. Two cDNA libraries were constructed with directional cloning method, one for regenerating intestine collected on the third, fourth and fifth day after evisceration (post-evisceration, PE), and the other for the non-eviscerated (NE). A total of 730 ESTs were generated by sequencing cDNA clones from the two libraries (372 from PE and 358 from NE). The results showed that the number of genes that were involved in primary metabolism of PE library was less than that of NE library, while the number of genes involved in cell defense/immunity, cell division, cell signal transduction/communication of PE library was more than that of NE library. The results also revealed that the expression of the genes which might be involved in regeneration was enhanced to some extent after evisceration. Only about 11.54% of the sequenced clones were shared by two libraries, which provided some clues for the existence of differential gene expression between PE and NE intestines. A gene named epenAj was also characterized in this study.

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“…Ependymin is involved in behaviours strongly linked with boldness, such as aggression and behavioural plasticity and learning (Shashoua, 1985), but is also involved in responses to environmental stress (e.g. Tang et al, 1999). CRF plays an integral role in the corticosteroid response to stress, initiating the HPI axis through binding to CRF Type I receptors in the pituitary to stimulate the secretion of ACTH (Chrousos and Gold, 1992).…”

Section: Introductionmentioning

confidence: 99%

Plasticity of boldness in rainbow trout, Oncorhynchus mykiss: do hunger and predation influence risk-taking behaviour?

Thomson

Watts

Pottinger

et al. 2012

Hormones and Behavior

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Article (refereed) -postprintThomson, Jack S.; Watts, Phillip C.; Pottinger, Tom G.; Sneddon, Lynne U. 2012 Plasticity of boldness in rainbow trout, Oncorhynchus mykiss: do hunger and predation influence risk-taking behaviour? Hormones and Behavior, 61 (5). 750-757. 10.1016/j.yhbeh.2012.03.014 Contact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. Boldness, a measure of an individual's propensity for taking risks, is an important determinant of fitness but is not necessarily a fixed trait. Dependent upon an individual's state, and given certain contexts or challenges, individuals may be able to alter their inclination to be bold or shy in response. Furthermore, the degree to which individuals can modulate their behaviour has been linked with physiological responses to stress. Here we attempted to determine whether bold and shy rainbow trout, Oncorhynchus mykiss, can exhibit behavioural plasticity in response to changes in state (nutritional availability) and context (predation threat). Individual trout were initially assessed for boldness using a standard novel object paradigm; subsequently, each day for one week fish experienced either predictable, unpredictable, or no simulated predator threat in combination with a high (2% body weight) or low (0.15%) food ration, before being reassessed for boldness. Bold trout were generally more plastic, altering levels of neophobia and activity relevant to the challenge, whereas shy trout were more fixed and remained shy. Increased predation risk generally resulted in an increase in the expression of three candidate genes linked to boldness, appetite regulation and physiological stress responses -ependymin, corticotrophin releasing factor and GABA A -but did not produce a significant increase in plasma cortisol. Plasticity of boldness in rainbow troutThe results suggest a divergence in the ability of bold and shy trout to alter their behavioural profiles in response to internal and exogenous factors, and have important implications for our understanding of the maintenance of different behavioural phenotypes in natural populations.

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Cold‐induced ependymin expression in zebrafish and carp brain: implications for cold acclimation

Cited by 40 publications

References 36 publications

Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish

Transcriptomic and genomic evolution under constant cold in Antarctic notothenioid fish

Comparative analysis of genes expressed in regenerating intestine and non-eviscerated intestine of Apostichopus japonicus Selenka (Aspidochirotida: Stichopodidae) and cloning of ependymin gene

Plasticity of boldness in rainbow trout, Oncorhynchus mykiss: do hunger and predation influence risk-taking behaviour?

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