Cold exposure, gut microbiota and health implications: A narrative review

Zhou, Erkai; Zhang, Ling; He, Li; Xiao, Ya; Zhang, Kai; Luo, Bin

doi:10.1016/j.scitotenv.2024.170060

Cited by 1 publication

(3 citation statements)

References 130 publications

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“…Reduced richness and decreased α-diversity [108] Increased gut permeability, apoptosis (cell death), inflammation, and oxidative stress [109] Secretion of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α [109] Secretion of butyric acid with the activation of the cAMP-PKA-pCREB signaling pathway [110] SCFAs and LPS can modulate local levels of T3 increased by cold temperatures [111] Abbreviations: GM, gut microbiota; IL, interleukin; CXCL2, chemokine (C-X-C motif) ligand 2; CCL, chemokine (C-C motif) ligand; ALT, alanine transaminase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; α-HBDH, α-hydroxybutyrate dehydrogenase; TNF, tumor necrosis factor; SCFAs, short-chain fatty acids; LPS, lipopolysaccharides; T3, triiodothyronine.…”

Section: Temperature Alteration Of Gm Referencesmentioning

confidence: 99%

“…Recent research has revealed that exposure to cold triggers alterations in the diversity and quality of GM species [ 110 ]. Short-term or sporadic exposure to cold did not appear to result in a general reduction in the α-diversity of GM.…”

Section: Climate Change and The Gut Microbiomementioning

confidence: 99%

“…Specifically, SCFAs, particularly butyric acid, and their receptors can activate the cAMP-PKA-pCREB signaling pathway, leading to the secretion and release of NE in BAT. NE manipulation can also induce alterations in GM composition [ 110 ].…”

Section: Climate Change and The Gut Microbiomementioning

confidence: 99%

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The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Rio,

Caldarelli,

Gasbarrini

et al. 2024

Diseases

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According to the definition provided by the United Nations, “climate change” describes the persistent alterations in temperatures and weather trends. These alterations may arise naturally, such as fluctuations in the solar cycle. Nonetheless, since the 19th century, human activities have emerged as the primary agent for climate change, primarily attributed to the combustion of fossil fuels such as coal, oil, and gas. Climate change can potentially influence the well-being, agricultural production, housing, safety, and employment opportunities for all individuals. The immune system is an important interface through which global climate change affects human health. Extreme heat, weather events and environmental pollutants could impair both innate and adaptive immune responses, promoting inflammation and genomic instability, and increasing the risk of autoimmune and chronic inflammatory diseases. Moreover, climate change has an impact on both soil and gut microbiome composition, which can further explain changes in human health outcomes. This narrative review aims to explore the influence of climate change on human health and disease, focusing specifically on its effects on the immune system and gut microbiota. Understanding how these factors contribute to the development of physical and mental illness may allow for the design of strategies aimed at reducing the negative impact of climate and pollution on human health.

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