Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

Boeckmann, Lars; Schäfer, Mirijam; Bernhardt, Thoralf; Semmler, María Eugenia Aubet; Jung, Ole; Ojak, Gregor; Fischer, Tobias; Peters, Kirsten; Nebe, Barbara; Müller‐Hilke, Brigitte; Seebauer, Christian; Bekeschus, Sander; Emmert, Steffen

doi:10.3390/app10196898

Cited by 59 publications

(45 citation statements)

References 95 publications

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“…The effect of plasma on biological mechanisms was revealed with the formation of reactive oxygen and nitrogen species (RONS) with NTAP irradiation [19]. However, the type of effect obtained as a result of application, especially in living tissues (such as inflammation [20], cell migration [21] and adhesion [22], wound healing and, apoptosis [23]), is determined by the concentration of RONS produced [24]. The properties obtained with NTAP, including bone regeneration and bactericidal effects, make plasma an advantageous therapy in the treatment of chronic infections such as periodontitis [25].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the protective effects of non-thermal atmospheric plasma on alveolar bone loss in experimental periodontitis

2021

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Objectives The inhibition of bone destruction is one of the main goals of periodontitis treatment. The aim of this study was to investigate the protective effects of non-thermal atmospheric plasma (NTAP) on alveolar bone loss radiographically, histomorphometrically, and histologically in experimental periodontitis in rats. Materials and methods A total of twenty-eight rats were randomly divided into three groups: control group (CG) (n = 8), periodontitis group (PG) (n = 10), and NTAP group (NTAPG) (n = 10). In PG and NTAPG, experimental periodontitis was created with ligating. The kINPen 11 plasma jet was applied around the ligatured teeth in NTAPG. The samples from each group were radiographically assessed with microcomputed tomography (micro-CT); then, histological (presence of osteoclasts and inflammatory cells) and immunohistochemical (immunoreactive of OCN and ALP) findings were compared. ResultsThe results revealed a significant increase in alveolar bone loss in the PG compared with CG and NTAPG (p < 0.05). Inflammation, alveolar resorption, and cement damage were reduced significantly in the group treated with NTAP compared to the PG (p < 0.05). Significantly higher levels of osteoclasts were detected in the PG in comparison with both CG and NTAPG (p < 0.05). The lowest osteocalcin and ALP values were determined in PG, and the differences between PG and both groups were also significant (p < 0.05). Conclusion Within the limitations of the present study, we can say that NTAP may enhance the bone remodeling process by inhibiting inflammation and preventing alveolar bone destruction.Clinical relevance NTAP has clinical potential for accelerating and treating periodontitis with the inflammatory response modulation, osteoblast differentiation, and alveolar bone loss reduction.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the protective effects of non-thermal atmospheric plasma on alveolar bone loss in experimental periodontitis

2021

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“…Of the three devices currently marketed based on thorough clinical experience and medical product guideline compliance or FDA approval specifically for chronic wound healing in dermatology, two are DBDs (PlasmaDerm from Cinogy and SteriPlas from Adtec), and one is a jet (kINPen MED from neoplas med). All have been investigated in clinical trials, as summarized before [127]- [129]. Two more devices from Germany, PlasmaCare from TerraPlasma (clinical trial completed) and a silicon-based plasma-plaster called CPTpatch from the INP spin-off company ColdPlasmaTech (clinical trial in preparation), are within authorization phases.…”

Section: A Current Statementioning

confidence: 99%

Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

Laroussi

Bekeschus

Keidar

et al. 2022

IEEE Trans. Radiat. Plasma Med. Sci.

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Plasma, the fourth and most pervasive state of matter in the visible universe, is a fascinating medium that is connected to the beginning of our universe itself. Man-made plasmas are at the core of many technological advances that include the fabrication of semiconductor devices, which enabled the modern computer and communication revolutions. The introduction of low temperature, atmospheric pressure plasmas to the biomedical field has ushered a new revolution in the healthcare arena that promises to introduce plasma-based therapies to combat some thorny and long-standing medical challenges. This article presents an overview of where research is at today and discusses innovative concepts and approaches to overcome present challenges and take the field to the next level. It is written by a team of experts who took an in-depth look at the various applications of plasma in hygiene, decontamination, and medicine, made critical analysis, and proposed ideas and concepts that should help the research community focus their efforts on clear and practical steps necessary to keep the field advancing for decades to come.

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“…Thus, new, additively acting and wound healing promoting interventions are urgently needed that may markedly reduce treatment time and, thus, related treatment costs. Cold atmospheric plasma (CAP) with its multimodal mechanisms of action definitely constitutes such an innovative intervention [4,5]. CAP reduces the bacterial load on wounds and re-initiates the stagnated healing process [2,6].…”

Section: Introductionmentioning

confidence: 99%

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

Cited by 59 publications

References 95 publications

Evaluation of the protective effects of non-thermal atmospheric plasma on alveolar bone loss in experimental periodontitis

Evaluation of the protective effects of non-thermal atmospheric plasma on alveolar bone loss in experimental periodontitis

Low-Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

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