Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Gao, Jing; Wang, Liyun; Xia, Chuankai; Yang, Xingyu; Cao, Zhicheng; Lei, Zheng Bao; Ko, Randy; Shen, Changbing; Yang, Chonglin; Cheng, Cheng

doi:10.1111/iwj.13161

Cited by 34 publications

(30 citation statements)

References 23 publications

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“…There was resultant rapid re-epithelisation, angiogenesis, collagen synthesis, and increased tissue mechanical strength after plasma exposure. Guo and colleagues [50] investigated CAP effects on various chronic wounds, including pyoderma gangrenosum, giant genital warts, and diabetic foot ulcers. The pyoderma gangrenosum patient had previously been unsuccessfully treated with antibiotics.…”

Section: Use Of Cold Plasma For Treatment Of Chronic and Acute Woundsmentioning

confidence: 99%

“…Although no significant differences were observed in the groups' overall wound healing, the CAP group had the most reduced skin redness and mean roughness. Gao et al [50] investigated the effect of cold plasma on two traumatic wounds. The first patient had used inappropriate self-treatment with glucocorticoids and mupirocin, which resulted in self-inflicted secondary eczema with exudation and crusting.…”

Section: Use Of Cold Plasma For Treatment Of Chronic and Acute Woundsmentioning

confidence: 99%

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Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Braný

Dvorska

Halašová

et al. 2020

IJMS

186

110

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Cold atmospheric plasma use in clinical studies is mainly limited to the treatment of chronic wounds, but its application in a wide range of medical fields is now the goal of many analyses. It is therefore likely that its application spectrum will be expanded in the future. Cold atmospheric plasma has been shown to reduce microbial load without any known significant negative effects on healthy tissues, and this should enhance its possible application to any microbial infection site. It has also been shown to have anti-tumour effects. In addition, it acts proliferatively on stem cells and other cultivated cells, and the highly increased nitric oxide levels have a very important effect on this proliferation. Cold atmospheric plasma use may also have a beneficial effect on immunotherapy in cancer patients. Finally, it is possible that the use of plasma devices will not remain limited to surface structures, because current endeavours to develop sufficiently miniature microplasma devices could very likely lead to its application in subcutaneous and internal structures. This study summarises the available literature on cold plasma action mechanisms and analyses of its current in vivo and in vitro use, primarily in the fields of regenerative and dental medicine and oncology.

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Section: Use Of Cold Plasma For Treatment Of Chronic and Acute Woundsmentioning

confidence: 99%

Section: Use Of Cold Plasma For Treatment Of Chronic and Acute Woundsmentioning

confidence: 99%

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Braný

Dvorska

Halašová

et al. 2020

IJMS

186

110

View full text Add to dashboard Cite

show abstract

“…Recently, CAP was applied for the improvement of wound healing in different types of superficial skin erosion wounds, including patients with pyoderma gangrenosum, trauma wounds, giant genital warts, diabetic foot, and chronic eczema. According to data obtained from the different wound types, CAP accelerates wound healing through the eradication of bacterial colonisation, sterilisation of the wound, changing the local wound environment, and the promotion of tissue restoration [197].…”

Section: Plasma Promoted Wound Healing and Its Possibilities In The Smentioning

confidence: 99%

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology

Žúbor

Wang

Líšková

et al. 2020

IJMS

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Vulvar cancer (VC) is a specific form of malignancy accounting for 5–6% of all gynaecologic malignancies. Although VC occurs most commonly in women after 60 years of age, disease incidence has risen progressively in premenopausal women in recent decades. VC demonstrates particular features requiring well-adapted therapeutic approaches to avoid potential treatment-related complications. Significant improvements in disease-free survival and overall survival rates for patients diagnosed with post-stage I disease have been achieved by implementing a combination therapy consisting of radical surgical resection, systemic chemotherapy and/or radiotherapy. Achieving local control remains challenging. However, mostly due to specific anatomical conditions, the need for comprehensive surgical reconstruction and frequent post-operative healing complications. Novel therapeutic tools better adapted to VC particularities are essential for improving individual outcomes. To this end, cold atmospheric plasma (CAP) treatment is a promising option for VC, and is particularly appropriate for the local treatment of dysplastic lesions, early intraepithelial cancer, and invasive tumours. In addition, CAP also helps reduce inflammatory complications and improve wound healing. The application of CAP may realise either directly or indirectly utilising nanoparticle technologies. CAP has demonstrated remarkable treatment benefits for several malignant conditions, and has created new medical fields, such as “plasma medicine” and “plasma oncology”. This article highlights the benefits of CAP for the treatment of VC, VC pre-stages, and postsurgical wound complications. There has not yet been a published report of CAP on vulvar cancer cells, and so this review summarises the progress made in gynaecological oncology and in other cancers, and promotes an important, understudied area for future research. The paradigm shift from reactive to predictive, preventive and personalised medical approaches in overall VC management is also considered.

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“…Cold atmospheric plasma is gaining increasing interest in many medical applications, such as wound healing, [ 1–3 ] skin disease treatment, [ 4,5 ] and cancer therapy. [ 6–8 ] It is a cocktail that consists of various physical and chemical components, including electrons, ions, neutrals, strong electric field, heat, and ultraviolet light, which may influence the therapeutic effects.…”

Section: Introductionmentioning

confidence: 99%

The penetration of reactive oxygen and nitrogen species across the stratum corneum

Duan

Yusupov

et al. 2020

Plasma Processes & Polymers

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The penetration of reactive oxygen and nitrogen species (RONS) across the stratum corneum (SC) is a necessary and crucial process in many skin-related plasma medical applications. To gain more insights into this penetration behavior, we combined experimental measurements of the permeability of dry and moist SC layers with computer simulations of model lipid membranes. We measured the permeation of relatively stable molecules, which are typically generated by plasma, namely H 2 O 2 , NO 3 − , and NO 2 −. Furthermore, we calculated the permeation free energy profiles of the major plasma-generated RONS and their derivatives (i.e., H 2 O 2 , OH, HO 2 , O 2 , O 3 , NO, NO 2 , N 2 O 4 , HNO 2 , HNO 3 , NO 2 − , and NO 3 −) across native and oxidized SC lipid bilayers, to understand the mechanisms of RONS permeation across the SC. Our results indicate that hydrophobic RONS (i.e., NO, NO 2 , O 2 , O 3 , and N 2 O 4) can translocate more easily across the SC lipid bilayer than hydrophilic RONS (i.e., H 2 O 2 , OH, HO 2 , HNO 2 , and HNO 3) and ions (i.e., NO 2 − and NO 3 −) that experience much higher permeation barriers. The permeability of RONS through the SC skin lipids is enhanced when the skin is moist and the lipids are oxidized. These findings may help to understand the underlying mechanisms of plasma interaction with a biomaterial and to optimize the environmental parameters in practice in plasma medical applications.

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Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Cited by 34 publications

References 23 publications

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology

The penetration of reactive oxygen and nitrogen species across the stratum corneum

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