Cold Atmospheric Plasma Conveys Selectivity Against Hepatocellular Carcinoma Cells via Triggering EGFR(Tyr1068)-Mediated Autophagy

Wang, Danjun; Zhang, Jianying; Cai, Linhan; Dai, Xiaofeng

doi:10.3389/fonc.2022.895106

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…Hence, p-JNK binds to the BIRC6 protein, which, under natural conditions, binds to LC3B, leading to its ubiquitination and degradation. When BIRC6 binds to p-JNK, the free LC3B protein can stimulate the initiation of autophagy [105].…”

Section: Differentiation Of Cap-induced Apoptosis and Autophagy Mecha...mentioning

confidence: 99%

The Promising Potential of Cold Atmospheric Plasma Therapies

Stańczyk,

Wiśniewski

2024

Plasma

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The outstanding properties and chemistry of cold atmospheric plasma (CAP) are not sufficiently understood due to their relatively complex systems and transient properties. In this paper, we tried to present a detailed review of the applications of CAP in modern medicine, highlighting the biochemistry of this phenomenon. Due to its unique characteristics, CAP has emerged as a promising tool in various medical applications. CAP, as a partially—or fully ionized—gas-retaining state of quasi-neutrality, contains many particles, such as electrons, charged atoms, and molecules displaying collective behaviour caused by Coulomb interactions. CAP can be generated at atmospheric pressure, making it suitable for medical settings. Cold plasma’s anti-microbial properties create an alternative method to antibiotics when treating infections. It also enhances cell proliferation, migration, and differentiation, leading to accelerated tissue regeneration. CAP can also be a powerful tool in anti-tumour therapies, stem cell proliferation, dental applications, and disease treatment, e.g., neurology. It is our belief that this article contributes to the deeper understanding of cold plasma therapy and its potential in medicine. The objective of this study is to demonstrate the potential of this relatively novel approach as a promising treatment modality. By covering a range of various biomedical fields, we hope to provide a comprehensive overview of CAP applications for multiple medical conditions. In order to gain further insight into the subject, we attempted to gather crucial research and evidence from various studies, hopefully creating a compelling argument in favour of CAP therapy. Our aim is to highlight the innovative aspects of CAP therapy where traditional methods may have limitations. Through this article, we intend to provide a convenient reference source for readers engaged in the examination of CAP’s potential in medicine.

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Section: Differentiation Of Cap-induced Apoptosis and Autophagy Mecha...mentioning

confidence: 99%

The Promising Potential of Cold Atmospheric Plasma Therapies

Stańczyk,

Wiśniewski

2024

Plasma

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“…IFNγ may synergize with CAP in suppressing SI spheroid growth via IFNγ/IFNGR2/APC/TCF/GPX4 signaling Cold atmospheric plasma (CAP) is an emerging oncotherapeutic approach for cancer treatment as well as many other diseases [25]. Its efficacy against malignant cells has been demonstrated in various malignant cells such as colorectal cancers [26], liver cancers [27], stomach cancers [28], pancreatic cancers [29], and has been shown capable of damaging cancer stem cells [30].…”

Section: Ifnγ Suppresses Si Spheroid Growth Via the Ifnγ/ifngr2/apc Axismentioning

confidence: 99%

IFNγ synergies with cold atmospheric plasma in triggering colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis

Lv,

He,

Dai

et al. 2023

Aging

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Colorectal cancer accounts for the second most common cancer-related lethality. Intestinal stem cells are responsible for enteric homeostasis maintenance that, once being transformed, become colorectal cancer stem cells. Arresting cancer stemness represents an innovative strategy for colorectal cancer management. Using intestinal stem cell organoids as the primary model, we screened common inflammatory cytokines to identify key players targeting cancer stemness. We also explored the downstream signaling that drives the functionalities of the identified cytokine through both experimental investigations and computational predictions. As the results, we identified IFNγ as the key cytokine capable of arresting intestinal stem cells via the IFNγ/IFNGR2/APC/TCF4/GPX4 axis, proposed its role in killing colorectal cancer stem cells via triggering GPX4-dependent ferroptosis, and demonstrated its synergistic anti-cancer effect with cold atmospheric plasma in killing colorectal cancer cells that is worthy to be experimentally validated.

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“…Cold atmospheric plasma (CAP), composed of hydroxyl radical (OH·), singleton oxygen (O), superoxide (O 2- ), nitric oxide (NO), hydrogen peroxide (H 2 O 2 ), ozone (O 3 ), and nitrite in the form of anion or proton (OONO - , ONOOH) ( 79 , 80 ), is a redox modulating tool and a promising onco-therapeutics with selectivity against malignant cells documented in various cancers such as melanomas ( 81 , 82 ), prostate cancers ( 83 ), breast tumors ( 80 , 84 ), bladder cancers ( 85 ), pancreatic cancers ( 86 ), liver carcinomas ( 87 ). By imposing a redox stress and elevating cellular ROS level, CAP may perturb HIF1α signaling and thus the redox status of transformed cells.…”

Section: Targeting Succinylation Via Redox Interve...mentioning

confidence: 99%

Succinylation and redox status in cancer cells

et al. 2022

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Succinylation is a post-translational modification (PTM) event that associates metabolic reprogramming with various pathological disorders including cancers via transferring a succinyl group to a residue of the target protein in an enzymic or non-enzymic manner. With our incremental knowledge on the roles of PTM played in tumor initiation and progression, relatively little has been focused on succinylation and its clinical implications. By delineating the associations of succinylation with cancer hallmarks, we identify the, in general, promotive roles of succinylation in manifesting cancer hallmarks, and conceptualize two working modes of succinylation in driving oncogenic signaling, i.e., via altering the structure and charge of target proteins towards enhanced stability and activity. We also characterize succinylation as a reflection of cellular redox homeostatic status and metabolic state, and bring forth the possible use of hyper-succinylated genome for early cancer diagnosis or disease progression indication. In addition, we propose redox modulation tools such as cold atmospheric plasma as a promising intervention approach against tumor cells and cancer stemness via targeting the redox homeostatic environment cells established under a pathological condition such as hypoxia. Taken together, we emphasize the central role of succinylation in bridging the gap between cellular metabolism and redox status, and its clinical relevance as a mark for cancer diagnosis as well as a target in onco-therapeutics.

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Cold Atmospheric Plasma Conveys Selectivity Against Hepatocellular Carcinoma Cells via Triggering EGFR(Tyr1068)-Mediated Autophagy

Cited by 7 publications

References 51 publications

The Promising Potential of Cold Atmospheric Plasma Therapies

The Promising Potential of Cold Atmospheric Plasma Therapies

IFNγ synergies with cold atmospheric plasma in triggering colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis

Succinylation and redox status in cancer cells

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